Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Science 293 (5535): 1653-1657

Copyright © 2001 by the American Association for the Advancement of Science

Duration of Nuclear NF-kappa B Action Regulated by Reversible Acetylation

Lin-feng Chen,1 Wolfgang Fischle,1 Eric Verdin,12 Warner C. Greene123*

The nuclear expression and action of the nuclear factor kappa B (NF-kappa B) transcription factor requires signal-coupled phosphorylation and degradation of the Ikappa B inhibitors, which normally bind and sequester this pleiotropically active factor in the cytoplasm. The subsequent molecular events that regulate the termination of nuclear NF-kappa B action remain poorly defined, although the activation of de novo Ikappa Balpha gene expression by NF-kappa B likely plays a key role. Our studies now demonstrate that the RelA subunit of NF-kappa B is subject to inducible acetylation and that acetylated forms of RelA interact weakly, if at all, with Ikappa Balpha . Acetylated RelA is subsequently deacetylated through a specific interaction with histone deacetylase 3 (HDAC3). This deacetylation reaction promotes effective binding to Ikappa Balpha and leads in turn to Ikappa Balpha -dependent nuclear export of the complex through a chromosomal region maintenance-1 (CRM-1)-dependent pathway. Deacetylation of RelA by HDAC3 thus acts as an intranuclear molecular switch that both controls the duration of the NF-kappa B transcriptional response and contributes to the replenishment of the depleted cytoplasmic pool of latent NF-kappa B-Ikappa Balpha complexes.

1 Gladstone Institute of Virology and Immunology,
2 Department of Medicine,
3 Department of Microbiology and Immunology, University of California, San Francisco, CA 94141, USA.
*   To whom correspondence should be addressed. E-mail: wgreene{at}gladstone.ucsf.edu


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A comprehensive map of the toll-like receptor signaling network.
K. Oda and H. Kitano (2014)
Mol Syst Biol 2, 2006.0015
   Abstract »    Full Text »    PDF »
Histone deacetylase isoforms regulate innate immune responses by deacetylating mitogen-activated protein kinase phosphatase-1.
Y. Jeong, R. Du, X. Zhu, S. Yin, J. Wang, H. Cui, W. Cao, and C. J. Lowenstein (2014)
J. Leukoc. Biol. 95, 651-659
   Abstract »    Full Text »    PDF »
Histone Deacetylases: A Saga of Perturbed Acetylation Homeostasis in Cancer.
S. Parbin, S. Kar, A. Shilpi, D. Sengupta, M. Deb, S. K. Rath, and S. K. Patra (2014)
Journal of Histochemistry & Cytochemistry 62, 11-33
   Abstract »    Full Text »    PDF »
Sirtuin and pan-class I/II deacetylase (DAC) inhibition is synergistic in preclinical models and clinical studies of lymphoma.
J. E. Amengual, S. Clark-Garvey, M. Kalac, L. Scotto, E. Marchi, E. Neylon, P. Johannet, Y. Wei, J. Zain, and O. A. O'Connor (2013)
Blood 122, 2104-2113
   Abstract »    Full Text »    PDF »
Silent Information Regulator 1 Protects the Brain Against Cerebral Ischemic Damage.
M. Hernandez-Jimenez, O. Hurtado, M. I. Cuartero, I. Ballesteros, A. Moraga, J. M. Pradillo, M. W. McBurney, I. Lizasoain, and M. A. Moro (2013)
Stroke 44, 2333-2337
   Abstract »    Full Text »    PDF »
L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors.
C. Nasca, D. Xenos, Y. Barone, A. Caruso, S. Scaccianoce, F. Matrisciano, G. Battaglia, A. A. Mathe, A. Pittaluga, L. Lionetto, et al. (2013)
PNAS 110, 4804-4809
   Abstract »    Full Text »    PDF »
The Roles of SIRT1 in Cancer.
Z. Lin and D. Fang (2013)
Genes & Cancer 4, 97-104
   Abstract »    Full Text »    PDF »
Involvement of p300/CBP and epigenetic histone acetylation in TGF-{beta}1-mediated gene transcription in mesangial cells.
H. Yuan, M. A. Reddy, G. Sun, L. Lanting, M. Wang, M. Kato, and R. Natarajan (2013)
Am J Physiol Renal Physiol 304, F601-F613
   Abstract »    Full Text »    PDF »
BRMS1 Suppresses Lung Cancer Metastases through an E3 Ligase Function on Histone Acetyltransferase p300.
Y. Liu, M. W. Mayo, A. S. Nagji, E. H. Hall, L. S. Shock, A. Xiao, E. B. Stelow, and D. R. Jones (2013)
Cancer Res. 73, 1308-1317
   Abstract »    Full Text »    PDF »
A Role for Cytoskeletal Protein Acetylation in Modulating Myometrial Activity.
G. N. Europe-Finner, M. J. Taggart, and M. Karolczak-Bayatti (2013)
Reproductive Sciences 20, 175-181
   Abstract »    Full Text »    PDF »
The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-{kappa}B.
E. Ziesche, D. Kettner-Buhrow, A. Weber, T. Wittwer, L. Jurida, J. Soelch, H. Muller, D. Newel, P. Kronich, H. Schneider, et al. (2013)
Nucleic Acids Res. 41, 90-109
   Abstract »    Full Text »    PDF »
Inflammatory Cytokines Promote Mesenchymal Transformation in Embryonic and Adult Valve Endothelial Cells.
G. J. Mahler, E. J. Farrar, and J. T. Butcher (2013)
Arterioscler Thromb Vasc Biol 33, 121-130
   Abstract »    Full Text »    PDF »
Resveratrol Sensitizes Acute Myelogenous Leukemia Cells to Histone Deacetylase Inhibitors through Reactive Oxygen Species-Mediated Activation of the Extrinsic Apoptotic Pathway.
A. Yaseen, S. Chen, S. Hock, R. Rosato, P. Dent, Y. Dai, and S. Grant (2012)
Mol. Pharmacol. 82, 1030-1041
   Abstract »    Full Text »    PDF »
Resveratrol Modulates Interleukin-1{beta}-induced Phosphatidylinositol 3-Kinase and Nuclear Factor {kappa}B Signaling Pathways in Human Tenocytes.
F. Busch, A. Mobasheri, P. Shayan, C. Lueders, R. Stahlmann, and M. Shakibaei (2012)
J. Biol. Chem. 287, 38050-38063
   Abstract »    Full Text »    PDF »
Sirt-1 Is Required for the Inhibition of Apoptosis and Inflammatory Responses in Human Tenocytes.
F. Busch, A. Mobasheri, P. Shayan, R. Stahlmann, and M. Shakibaei (2012)
J. Biol. Chem. 287, 25770-25781
   Abstract »    Full Text »    PDF »
Folate deprivation enhances invasiveness of human colon cancer cells mediated by activation of sonic hedgehog signaling through promoter hypomethylation and cross action with transcription nuclear factor-kappa B pathway.
T.-P. Wang, S.-H. Hsu, H.-C. Feng, and R.-F. S. Huang (2012)
Carcinogenesis 33, 1158-1168
   Abstract »    Full Text »    PDF »
Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation.
H. Lee, P. Zhang, A. Herrmann, C. Yang, H. Xin, Z. Wang, D. S. B. Hoon, S. J. Forman, R. Jove, A. D. Riggs, et al. (2012)
PNAS 109, 7765-7769
   Abstract »    Full Text »    PDF »
Neutrophil Gelatinase-associated Lipocalin (NGAL) Expression Is Dependent on the Tumor-associated Sigma-2 Receptor S2RPgrmc1.
S. U. R. Mir, L. Jin, and R. J. Craven (2012)
J. Biol. Chem. 287, 14494-14501
   Abstract »    Full Text »    PDF »
Human immunodeficiency virus-1 Tat activates NF-{kappa}B via physical interaction with I{kappa}B-{alpha} and p65.
G. Fiume, E. Vecchio, A. De Laurentiis, F. Trimboli, C. Palmieri, A. Pisano, C. Falcone, M. Pontoriero, A. Rossi, A. Scialdone, et al. (2012)
Nucleic Acids Res. 40, 3548-3562
   Abstract »    Full Text »    PDF »
Inhibition of Histone Deacetylases Preserves Myocardial Performance and Prevents Cardiac Remodeling through Stimulation of Endogenous Angiomyogenesis.
L. Zhang, X. Qin, Y. Zhao, L. Fast, S. Zhuang, P. Liu, G. Cheng, and T. C. Zhao (2012)
J. Pharmacol. Exp. Ther. 341, 285-293
   Abstract »    Full Text »    PDF »
Therapeutic Efficacy of CEP-33779, a Novel Selective JAK2 Inhibitor, in a Mouse Model of Colitis-Induced Colorectal Cancer.
M. M. Seavey, L. D. Lu, K. L. Stump, N. H. Wallace, W. Hockeimer, T. M. O'Kane, B. A. Ruggeri, and P. Dobrzanski (2012)
Mol. Cancer Ther. 11, 984-993
   Abstract »    Full Text »    PDF »
HDAC inhibitor therapy in autoimmunity and transplantation.
W. W. Hancock, T. Akimova, U. H. Beier, Y. Liu, and L. Wang (2012)
Ann Rheum Dis 71, i46-i54
   Abstract »    Full Text »    PDF »
Identification of a Nuclear Localization Sequence in {beta}-Arrestin-1 and Its Functional Implications.
C. Z. Hoeppner, N. Cheng, and R. D. Ye (2012)
J. Biol. Chem. 287, 8932-8943
   Abstract »    Full Text »    PDF »
Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay.
A. M. Grabiec, O. Korchynskyi, P. P. Tak, and K. A. Reedquist (2012)
Ann Rheum Dis 71, 424-431
   Abstract »    Full Text »    PDF »
NF-{kappa}B, the first quarter-century: remarkable progress and outstanding questions.
M. S. Hayden and S. Ghosh (2012)
Genes & Dev. 26, 203-234
   Abstract »    Full Text »    PDF »
Anergic CD8+ T Lymphocytes Have Impaired NF-{kappa}B Activation with Defects in p65 Phosphorylation and Acetylation.
P. E. Clavijo and K. A. Frauwirth (2012)
J. Immunol. 188, 1213-1221
   Abstract »    Full Text »    PDF »
Epigenetic Mechanisms: Critical Contributors to Long-Term Memory Formation.
F. D. Lubin, S. Gupta, R. R. Parrish, N. M. Grissom, and R. L. Davis (2011)
Neuroscientist 17, 616-632
   Abstract »    PDF »
RelA Ser276 Phosphorylation-Coupled Lys310 Acetylation Controls Transcriptional Elongation of Inflammatory Cytokines in Respiratory Syncytial Virus Infection.
A. R. Brasier, B. Tian, M. Jamaluddin, M. K. Kalita, R. P. Garofalo, and M. Lu (2011)
J. Virol. 85, 11752-11769
   Abstract »    Full Text »    PDF »
Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies.
W. H. De Vos, F. Houben, M. Kamps, A. Malhas, F. Verheyen, J. Cox, E. M. M. Manders, V. L. R. M. Verstraeten, M. A. M. van Steensel, C. L. M. Marcelis, et al. (2011)
Hum. Mol. Genet. 20, 4175-4186
   Abstract »    Full Text »    PDF »
High Throughput Short Interfering RNA (siRNA) Screening of the Human Kinome Identifies Novel Kinases Controlling the Canonical Nuclear Factor-{kappa}B (NF-{kappa}B) Activation Pathway.
S. Choudhary, K. P. Rosenblatt, L. Fang, B. Tian, Z.-H. Wu, and A. R. Brasier (2011)
J. Biol. Chem. 286, 37187-37195
   Abstract »    Full Text »    PDF »
Disruption of I{kappa}B Kinase (IKK)-mediated RelA Serine 536 Phosphorylation Sensitizes Human Multiple Myeloma Cells to Histone Deacetylase (HDAC) Inhibitors.
Y. Dai, S. Chen, L. Wang, X.-Y. Pei, V. L. Funk, L. B. Kramer, P. Dent, and S. Grant (2011)
J. Biol. Chem. 286, 34036-34050
   Abstract »    Full Text »    PDF »
Kaposi's Sarcoma-Associated Herpesvirus-Encoded Latency-Associated Nuclear Antigen Reduces Interleukin-8 Expression in Endothelial Cells and Impairs Neutrophil Chemotaxis by Degrading Nuclear p65.
X. Li, D. Liang, X. Lin, E. S. Robertson, and K. Lan (2011)
J. Virol. 85, 8606-8615
   Abstract »    Full Text »    PDF »
Kruppel-Associated Box-Associated Protein 1 Negatively Regulates TNF-{alpha}-Induced NF-{kappa}B Transcriptional Activity by Influencing the Interactions among STAT3, p300, and NF-{kappa}B/p65.
S. Kamitani, S. Togi, O. Ikeda, M. Nakasuji, A. Sakauchi, Y. Sekine, R. Muromoto, K. Oritani, and T. Matsuda (2011)
J. Immunol. 187, 2476-2483
   Abstract »    Full Text »    PDF »
HIV Latency.
R. F. Siliciano and W. C. Greene (2011)
Cold Spring Harb Perspect Med 1, a007096
   Abstract »    Full Text »    PDF »
Structural Basis and Specificity of Acetylated Transcription Factor GATA1 Recognition by BET Family Bromodomain Protein Brd3.
R. Gamsjaeger, S. R. Webb, J. M. Lamonica, A. Billin, G. A. Blobel, and J. P. Mackay (2011)
Mol. Cell. Biol. 31, 2632-2640
   Abstract »    Full Text »    PDF »
Autophagosomal I{kappa}B{alpha} Degradation Plays a Role in the Long Term Control of Tumor Necrosis Factor-{alpha}-induced Nuclear Factor-{kappa}B (NF-{kappa}B) Activity.
A. Colleran, A. Ryan, A. O'Gorman, C. Mureau, C. Liptrot, P. Dockery, H. Fearnhead, and L. J. Egan (2011)
J. Biol. Chem. 286, 22886-22893
   Abstract »    Full Text »    PDF »
Role of histone deacetylases in vascular cell homeostasis and arteriosclerosis.
B. Zhou, A. Margariti, L. Zeng, and Q. Xu (2011)
Cardiovasc Res 90, 413-420
   Abstract »    Full Text »    PDF »
Resveratrol-mediated SIRT-1 Interactions with p300 Modulate Receptor Activator of NF-{kappa}B Ligand (RANKL) Activation of NF-{kappa}B Signaling and Inhibit Osteoclastogenesis in Bone-derived Cells.
M. Shakibaei, C. Buhrmann, and A. Mobasheri (2011)
J. Biol. Chem. 286, 11492-11505
   Abstract »    Full Text »    PDF »
Acetylation-Deacetylation of the Transcription Factor Nrf2 (Nuclear Factor Erythroid 2-related Factor 2) Regulates Its Transcriptional Activity and Nucleocytoplasmic Localization.
Y. Kawai, L. Garduno, M. Theodore, J. Yang, and I. J. Arinze (2011)
J. Biol. Chem. 286, 7629-7640
   Abstract »    Full Text »    PDF »
PC4/Tis7/IFRD1 Stimulates Skeletal Muscle Regeneration and Is Involved in Myoblast Differentiation as a Regulator of MyoD and NF-{kappa}B.
L. Micheli, L. Leonardi, F. Conti, G. Maresca, S. Colazingari, E. Mattei, S. A. Lira, S. Farioli-Vecchioli, M. Caruso, and F. Tirone (2011)
J. Biol. Chem. 286, 5691-5707
   Abstract »    Full Text »    PDF »
{alpha}-Synuclein Negatively Regulates Protein Kinase C{delta} Expression to Suppress Apoptosis in Dopaminergic Neurons by Reducing p300 Histone Acetyltransferase Activity.
H. Jin, A. Kanthasamy, A. Ghosh, Y. Yang, V. Anantharam, and A. G. Kanthasamy (2011)
J. Neurosci. 31, 2035-2051
   Abstract »    Full Text »    PDF »
Negative Feedback Regulation of NF-{kappa}B Action by CITED2 in the Nucleus.
X. Lou, S. Sun, W. Chen, Y. Zhou, Y. Huang, X. Liu, Y. Shan, and C. Wang (2011)
J. Immunol. 186, 539-548
   Abstract »    Full Text »    PDF »
A Noncompetitive Small Molecule Inhibitor of Estrogen-regulated Gene Expression and Breast Cancer Cell Growth That Enhances Proteasome-dependent Degradation of Estrogen Receptor {alpha}.
N. M. Kretzer, M. T. Cherian, C. Mao, I. O. Aninye, P. D. Reynolds, R. Schiff, P. J. Hergenrother, S. K. Nordeen, E. M. Wilson, and D. J. Shapiro (2010)
J. Biol. Chem. 285, 41863-41873
   Abstract »    Full Text »    PDF »
HDAC3 Is Negatively Regulated by the Nuclear Protein DBC1.
C. C. S. Chini, C. Escande, V. Nin, and E. N. Chini (2010)
J. Biol. Chem. 285, 40830-40837
   Abstract »    Full Text »    PDF »
High Mobility Group Box 1 Release from Hepatocytes during Ischemia and Reperfusion Injury Is Mediated by Decreased Histone Deacetylase Activity.
J. Evankovich, S. W. Cho, R. Zhang, J. Cardinal, R. Dhupar, L. Zhang, J. R. Klune, J. Zlotnicki, T. Billiar, and A. Tsung (2010)
J. Biol. Chem. 285, 39888-39897
   Abstract »    Full Text »    PDF »
SIRT2 regulates NF-{kappa}B-dependent gene expression through deacetylation of p65 Lys310.
K. M. Rothgiesser, S. Erener, S. Waibel, B. Luscher, and M. O. Hottiger (2010)
J. Cell Sci. 123, 4251-4258
   Abstract »    Full Text »    PDF »
Synergistic Activation of NF-{kappa}B by Bacterial Chemoattractant and TNF{alpha} Is Mediated by p38 MAPK-dependent RelA Acetylation.
W. W. Pan, J.-D. Li, S. Huang, T. J. Papadimos, Z. K. Pan, and L.-Y. Chen (2010)
J. Biol. Chem. 285, 34348-34354
   Abstract »    Full Text »    PDF »
Novel Changes in NF-{kappa}B Activity during Progression and Regression Phases of Hyperplasia: ROLE OF MEK, ERK, AND p38.
P. Chandrakesan, I. Ahmed, T. Anwar, Y. Wang, S. Sarkar, P. Singh, S. Peleg, and S. Umar (2010)
J. Biol. Chem. 285, 33485-33498
   Abstract »    Full Text »    PDF »
Specification of the NF-{kappa}B transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKK{varepsilon}.
R. Moreno, J.-M. Sobotzik, C. Schultz, and M. L. Schmitz (2010)
Nucleic Acids Res. 38, 6029-6044
   Abstract »    Full Text »    PDF »
Myeloid Deletion of SIRT1 Induces Inflammatory Signaling in Response to Environmental Stress.
T. T. Schug, Q. Xu, H. Gao, A. Peres-da-Silva, D. W. Draper, M. B. Fessler, A. Purushotham, and X. Li (2010)
Mol. Cell. Biol. 30, 4712-4721
   Abstract »    Full Text »    PDF »
Vitamin D3 Upregulated Protein 1 Suppresses TNF-{alpha}-Induced NF-{kappa}B Activation in Hepatocarcinogenesis.
H.-J. Kwon, Y.-S. Won, H.-W. Suh, J.-H. Jeon, Y. Shao, S.-R. Yoon, J.-W. Chung, T.-D. Kim, H.-M. Kim, K.-H. Nam, et al. (2010)
J. Immunol. 185, 3980-3989
   Abstract »    Full Text »    PDF »
Histone Deacetylase 3 Antagonizes Aspirin-Stimulated Endothelial Nitric Oxide Production by Reversing Aspirin-Induced Lysine Acetylation of Endothelial Nitric Oxide Synthase.
S.-B. Jung, C.-S. Kim, A. Naqvi, T. Yamamori, I. Mattagajasingh, T. A. Hoffman, M. P. Cole, A. Kumar, J. S. DeRicco, B.-H. Jeon, et al. (2010)
Circ. Res. 107, 877-887
   Abstract »    Full Text »    PDF »
A-kinase-interacting Protein 1 (AKIP1) Acts as a Molecular Determinant of PKA in NF-{kappa}B Signaling.
N. Gao, Y. Hibi, M. Cueno, K. Asamitsu, and T. Okamoto (2010)
J. Biol. Chem. 285, 28097-28104
   Abstract »    Full Text »    PDF »
HDAC Inhibition Attenuates Inflammatory, Hypertrophic, and Hypertensive Responses in Spontaneously Hypertensive Rats.
J. P. Cardinale, S. Sriramula, R. Pariaut, A. Guggilam, N. Mariappan, C. M. Elks, and J. Francis (2010)
Hypertension 56, 437-444
   Abstract »    Full Text »    PDF »
Mechanistic Insights into the Events That Lead to Synergistic Induction of Interleukin 6 Transcription upon Activation of the Aryl Hydrocarbon Receptor and Inflammatory Signaling.
B. C. DiNatale, J. C. Schroeder, L. J. Francey, A. Kusnadi, and G. H. Perdew (2010)
J. Biol. Chem. 285, 24388-24397
   Abstract »    Full Text »    PDF »
Benzyl Isothiocyanate-Mediated Inhibition of Histone Deacetylase Leads to NF-{kappa}B Turnoff in Human Pancreatic Carcinoma Cells.
S. Batra, R. P. Sahu, P. K. Kandala, and S. K. Srivastava (2010)
Mol. Cancer Ther. 9, 1596-1608
   Abstract »    Full Text »    PDF »
Targeted deletion of NF-{kappa}B p50 diminishes the cardioprotection of histone deacetylase inhibition.
L. X. Zhang, Y. Zhao, G. Cheng, T. L. Guo, Y. E. Chin, P. Y. Liu, and T. C. Zhao (2010)
Am J Physiol Heart Circ Physiol 298, H2154-H2163
   Abstract »    Full Text »    PDF »
The Mastermind-like 1 (MAML1) Co-activator Regulates Constitutive NF-{kappa}B Signaling and Cell Survival.
B. Jin, H. Shen, S. Lin, J. L. Li, Z. Chen, J. D. Griffin, and L. Wu (2010)
J. Biol. Chem. 285, 14356-14365
   Abstract »    Full Text »    PDF »
Histone Deacetylase Inhibitors Activate NF-{kappa}B in Human Leukemia Cells through an ATM/NEMO-related Pathway.
R. R. Rosato, S. S. Kolla, S. K. Hock, J. A. Almenara, A. Patel, S. Amin, P. Atadja, P. B. Fisher, P. Dent, and S. Grant (2010)
J. Biol. Chem. 285, 10064-10077
   Abstract »    Full Text »    PDF »
Spatio-temporal correlations can drastically change the response of a MAPK pathway.
K. Takahashi, S. Tanase-Nicola, and P. R. ten Wolde (2010)
PNAS 107, 2473-2478
   Abstract »    Full Text »    PDF »
Ubiquitination and Degradation of the Inhibitors of NF-{kappa}B.
N. Kanarek, N. London, O. Schueler-Furman, and Y. Ben-Neriah (2010)
Cold Spring Harb Perspect Biol 2, a000166
   Abstract »    Full Text »    PDF »
Epigallocatechin-3-gallate Inhibits Osteoclastogenesis by Down-Regulating c-Fos Expression and Suppressing the Nuclear Factor-{kappa}B Signal.
J.-H. Lee, H. Jin, H.-E. Shim, H.-N. Kim, H. Ha, and Z. H. Lee (2010)
Mol. Pharmacol. 77, 17-25
   Abstract »    Full Text »    PDF »
Histone Deacetylase Inhibitors in Cancer Therapy.
A. A. Lane and B. A. Chabner (2009)
J. Clin. Oncol. 27, 5459-5468
   Abstract »    Full Text »    PDF »
Helicobacter pylori CagA activates NF-{kappa}B by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination.
A. Lamb, X.-D. Yang, Y.-H. N. Tsang, J.-D. Li, H. Higashi, M. Hatakeyama, R. M. Peek, S. R. Blanke, and L.-F. Chen (2009)
EMBO Rep. 10, 1242-1249
   Abstract »    Full Text »    PDF »
Respiratory Syncytial Virus Infection Induces a Reactive Oxygen Species-MSK1-Phospho-Ser-276 RelA Pathway Required for Cytokine Expression.
M. Jamaluddin, B. Tian, I. Boldogh, R. P. Garofalo, and A. R. Brasier (2009)
J. Virol. 83, 10605-10615
   Abstract »    Full Text »    PDF »
Profiling Bioactivity of the ToxCast Chemical Library Using BioMAP Primary Human Cell Systems.
K. A. Houck, D. J. Dix, R. S. Judson, R. J. Kavlock, J. Yang, and E. L. Berg (2009)
J Biomol Screen 14, 1054-1066
   Abstract »    PDF »
A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9.
Y. Nakamaru, C. Vuppusetty, H. Wada, J. C. Milne, M. Ito, C. Rossios, M. Elliot, J. Hogg, S. Kharitonov, H. Goto, et al. (2009)
FASEB J 23, 2810-2819
   Abstract »    Full Text »    PDF »
Epigenetic Modulation of mGlu2 Receptors by Histone Deacetylase Inhibitors in the Treatment of Inflammatory Pain.
S. Chiechio, M. Zammataro, M. E. Morales, C. L. Busceti, F. Drago, R. W. Gereau IV, A. Copani, and F. Nicoletti (2009)
Mol. Pharmacol. 75, 1014-1020
   Abstract »    Full Text »    PDF »
The essential role of Oct-2 in LPS-induced expression of iNOS in RAW 264.7 macrophages and its regulation by trichostatin A.
S.-C. Lu, H.-W. Wu, Y.-J. Lin, and S.-F. Chang (2009)
Am J Physiol Cell Physiol 296, C1133-C1139
   Abstract »    Full Text »    PDF »
Negative regulation of NF-{kappa}B action by Set9-mediated lysine methylation of the RelA subunit.
X.-D. Yang, B. Huang, M. Li, A. Lamb, N. L. Kelleher, and L.-F. Chen (2009)
EMBO J. 28, 1055-1066
   Abstract »    Full Text »    PDF »
GCN5 is a required cofactor for a ubiquitin ligase that targets NF-{kappa}B/RelA.
X. Mao, N. Gluck, D. Li, G. N. Maine, H. Li, I. W. Zaidi, A. Repaka, M. W. Mayo, and E. Burstein (2009)
Genes & Dev. 23, 849-861
   Abstract »    Full Text »    PDF »
Brd4 Coactivates Transcriptional Activation of NF-{kappa}B via Specific Binding to Acetylated RelA.
B. Huang, X.-D. Yang, M.-M. Zhou, K. Ozato, and L.-F. Chen (2009)
Mol. Cell. Biol. 29, 1375-1387
   Abstract »    Full Text »    PDF »
Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease.
D. Pons, F. R. de Vries, P. J. van den Elsen, B. T. Heijmans, P. H.A. Quax, and J. W. Jukema (2009)
Eur. Heart J. 30, 266-277
   Abstract »    Full Text »    PDF »
Overexpression of SIRT1 Protects Pancreatic {beta}-Cells Against Cytokine Toxicity by Suppressing the Nuclear Factor-{kappa}B Signaling Pathway.
J.-H. Lee, M.-Y. Song, E.-K. Song, E.-K. Kim, W. S. Moon, M.-K. Han, J.-W. Park, K.-B. Kwon, and B.-H. Park (2009)
Diabetes 58, 344-351
   Abstract »    Full Text »    PDF »
Hyaluronan-mediated CD44 Interaction with p300 and SIRT1 Regulates {beta}-Catenin Signaling and NF{kappa}B-specific Transcription Activity Leading to MDR1 and Bcl-xL Gene Expression and Chemoresistance in Breast Tumor Cells.
L. Y. W. Bourguignon, W. Xia, and G. Wong (2009)
J. Biol. Chem. 284, 2657-2671
   Abstract »    Full Text »    PDF »
NF{kappa}B activation is associated with its O-GlcNAcylation state under hyperglycemic conditions.
W. H. Yang, S. Y. Park, H. W. Nam, D. H. Kim, J. G. Kang, E. S. Kang, Y. S. Kim, H. C. Lee, K. S. Kim, and J. W. Cho (2008)
PNAS 105, 17345-17350
   Abstract »    Full Text »    PDF »
Interleukin-8 Expression Is Regulated by Histone Deacetylases through the Nuclear Factor-{kappa}B Pathway in Breast Cancer.
C. Chavey, M. Muhlbauer, C. Bossard, A. Freund, S. Durand, C. Jorgensen, C. Jobin, and G. Lazennec (2008)
Mol. Pharmacol. 74, 1359-1366
   Abstract »    Full Text »    PDF »
Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals a Regulatory Structural Zinc-binding Domain.
M. J. Bottomley, P. Lo Surdo, P. Di Giovine, A. Cirillo, R. Scarpelli, F. Ferrigno, P. Jones, P. Neddermann, R. De Francesco, C. Steinkuhler, et al. (2008)
J. Biol. Chem. 283, 26694-26704
   Abstract »    Full Text »    PDF »
PKC{beta}II Augments NF-{kappa}B-Dependent Transcription at the CCL11 Promoter via p300/CBP-Associated Factor Recruitment and Histone H4 Acetylation.
D. L. Clarke, A. Sutcliffe, K. Deacon, D. Bradbury, L. Corbett, and A. J. Knox (2008)
J. Immunol. 181, 3503-3514
   Abstract »    Full Text »    PDF »
c-Rel, an NF-{kappa}B family transcription factor, is required for hippocampal long-term synaptic plasticity and memory formation.
H. J. Ahn, C. M. Hernandez, J. M. Levenson, F. D. Lubin, H.-C. Liou, and J. D. Sweatt (2008)
Learn. Mem. 15, 539-549
   Abstract »    Full Text »    PDF »
Histone Deacetylase Inhibitors Exert Time-Dependent Effects on Nuclear Factor-{kappa}B but Consistently Suppress the Expression of Proinflammatory Genes in Human Myometrial Cells.
T. M. Lindstrom, A. R. Mohan, M. R. Johnson, and P. R. Bennett (2008)
Mol. Pharmacol. 74, 109-121
   Abstract »    Full Text »    PDF »
Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling.
W. Cao, C. Bao, E. Padalko, and C. J. Lowenstein (2008)
J. Exp. Med. 205, 1491-1503
   Abstract »    Full Text »    PDF »
Inhibition of Transcription and DNA Replication by the Papillomavirus E8^E2C Protein Is Mediated by Interaction with Corepressor Molecules.
I. Ammermann, M. Bruckner, F. Matthes, T. Iftner, and F. Stubenrauch (2008)
J. Virol. 82, 5127-5136
   Abstract »    Full Text »    PDF »
Substance P enhances NF-{kappa}B transactivation and chemokine response in murine macrophages via ERK1/2 and p38 MAPK signaling pathways.
J. Sun, R. D. Ramnath, L. Zhi, R. Tamizhselvi, and M. Bhatia (2008)
Am J Physiol Cell Physiol 294, C1586-C1596
   Abstract »    Full Text »    PDF »
Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice.
H. Yao, I. Edirisinghe, S. Rajendrasozhan, S.-R. Yang, S. Caito, D. Adenuga, and I. Rahman (2008)
Am J Physiol Lung Cell Mol Physiol 294, L1174-L1186
   Abstract »    Full Text »    PDF »
Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice.
R. Glauben, A. Batra, T. Stroh, U. Erben, I. Fedke, H. A. Lehr, F. Leoni, P. Mascagni, C. A. Dinarello, M. Zeitz, et al. (2008)
Gut 57, 613-622
   Abstract »    Full Text »    PDF »
AKIP1 Enhances NF-{kappa}B-dependent Gene Expression by Promoting the Nuclear Retention and Phosphorylation of p65.
N. Gao, K. Asamitsu, Y. Hibi, T. Ueno, and T. Okamoto (2008)
J. Biol. Chem. 283, 7834-7843
   Abstract »    Full Text »    PDF »
Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment.
S. Ishii, Y. Kurasawa, J. Wong, and L.-y. Yu-Lee (2008)
PNAS 105, 4179-4184
   Abstract »    Full Text »    PDF »
Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65.
C. Buerki, K. M. Rothgiesser, T. Valovka, H. R. Owen, H. Rehrauer, M. Fey, W. S. Lane, and M. O. Hottiger (2008)
Nucleic Acids Res. 36, 1665-1680
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882