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Science 293 (5537): 2087-2092

Copyright © 2001 by the American Association for the Advancement of Science

A Gene Expression Map for Caenorhabditis elegans

Stuart K. Kim,1* Jim Lund,1 Moni Kiraly,1 Kyle Duke,1 Min Jiang,1 Joshua M. Stuart,2 Andreas Eizinger,1 Brian N. Wylie,3 George S. Davidson3

We have assembled data from Caenorhabditis elegans DNA microarray experiments involving many growth conditions, developmental stages, and varieties of mutants. Co-regulated genes were grouped together and visualized in a three-dimensional expression map that displays correlations of gene expression profiles as distances in two dimensions and gene density in the third dimension. The gene expression map can be used as a gene discovery tool to identify genes that are co-regulated with known sets of genes (such as heat shock, growth control genes, germ line genes, and so forth) or to uncover previously unknown genetic functions (such as genomic instability in males and sperm caused by specific transposons).

1 Department of Developmental Biology and Genetics, Stanford University Medical School, Stanford, CA 94305, USA.
2 Stanford Medical Informatics, 251 Campus Drive, MSOB X-215, Stanford, CA 94305, USA.
3 Computation, Computers and Mathematics Center, Sandia National Laboratories, Albuquerque, NM 87185-0318, USA.
*   To whom correspondence should be addressed. E-mail: kim{at}

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TagA, a putative serine protease/ABC transporter of Dictyostelium that is required for cell fate determination at the onset of development.
J. R. Good, M. Cabral, S. Sharma, J. Yang, N. Van Driessche, C. A. Shaw, G. Shaulsky, and A. Kuspa (2003)
Development 130, 2953-2965
   Abstract »    Full Text »    PDF »
Direct and Indirect Transcriptional Targets of DAF-16.
P. L. Larsen (2003)
Sci. Aging Knowl. Environ. 2003, pe9-9
   Abstract »    Full Text »
Global analysis of dauer gene expression in Caenorhabditis elegans.
J. Wang and S. K. Kim (2003)
Development 130, 1621-1634
   Abstract »    Full Text »    PDF »
A Potassium Channel-MiRP Complex Controls Neurosensory Function in Caenorhabditis elegans.
L. Bianchi, S.-M. Kwok, M. Driscoll, and F. Sesti (2003)
J. Biol. Chem. 278, 12415-12424
   Abstract »    Full Text »    PDF »

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