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BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF
Jeffrey S. Thompson,1Sarah A. Bixler,1Fang Qian,1Kalpit Vora,1*Martin L. Scott,1Teresa G. Cachero,1Catherine Hession,1Pascal Schneider,2Irene D. Sizing,1Colleen Mullen,1Kathy Strauch,1Mohammad Zafari,1Christopher D. Benjamin,1Jurg Tschopp,2Jeffrey L. Browning,1Christine Ambrose1
B cell homeostasis has been shown to critically depend on
BAFF, the B cell activation factor from the tumor necrosis factor(TNF) family. Although BAFF is already known to bind two
receptors,BCMA and TACI, we have identified a third receptor for BAFF
thatwe have termed BAFF-R. BAFF-R binding appears to be highly
specificfor BAFF, suggesting a unique role for this
ligand-receptor interaction.Consistent with this, the BAFF-R
locus is disrupted in A/WySnJmice, which display a B cell phenotype
qualitatively similar tothat of the BAFF-deficient mice. Thus, BAFF-R
appears to be theprincipal receptor for BAFF-mediated mature B cell
survival.
1 Biogen, 12 Cambridge Center, Cambridge, MA
02142, USA.
2 The Institute of Biochemistry,
University of Lausanne, CH-1066, Epalinges, Switzerland.
*
Present address: Department of Biologics Research, Merck & Co., 126 East Lincoln Avenue, RY 80Y-310, Rahway, NJ 07065, USA.
To whom correspondence should be addressed. E-mail:
christine_ambrose{at}biogen.com
The editors suggest the following Related Resources on Science sites:
In Science Magazine
REPORTS
Barbara Schiemann, Jennifer L. Gommerman, Kalpit Vora, Teresa G. Cachero, Svetlana Shulga-Morskaya, Max Dobles, Erica Frew, and Martin L. Scott (14 September 2001) Science293 (5537), 2111.
[DOI: 10.1126/science.1061964] |Abstract »|Full Text »|PDF »|Supplemental Data »
PERSPECTIVES
Thomas J. Waldschmidt and Randolph J. Noelle (14 September 2001) Science293 (5537), 2012.
[DOI: 10.1126/science.1065591] |Summary »|Full Text »|PDF »
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A BAFF antagonist suppresses experimental autoimmune encephalomyelitis by targeting cell-mediated and humoral immune responses.
N. D. Huntington, R. Tomioka, C. Clavarino, A. M. Chow, D. Linares, P. Mana, J. Rossjohn, T. G. Cachero, F. Qian, S. L. Kalled, et al. (2006)
Int. Immunol.
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Paucity of Clinical Disease despite Serological Autoimmunity and Kidney Pathology in Lupus-Prone New Zealand Mixed 2328 Mice Deficient in BAFF.
C. O. Jacob, L. Pricop, C. Putterman, M. N. Koss, Y. Liu, M. Kollaros, S. A. Bixler, C. M. Ambrose, M. L. Scott, and W. Stohl (2006)
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177, 2671-2680
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Aberrant expression of BAFF in T cells of systemic lupus erythematosus, which is recapitulated by a human T cell line, Loucy.
K. Yoshimoto, Y. Takahashi, M. Ogasawara, Y. Setoyama, K. Suzuki, K. Tsuzaka, T. Abe, and T. Takeuchi (2006)
Int. Immunol.
18, 1189-1196
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Chronic Administration of Belimumab, a BLyS Antagonist, Decreases Tissue and Peripheral Blood B-Lymphocyte Populations in Cynomolgus Monkeys: Pharmacokinetic, Pharmacodynamic, and Toxicologic Effects.
W. G. Halpern, P. Lappin, T. Zanardi, W. Cai, M. Corcoran, J. Zhong, and K. P. Baker (2006)
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Space, Selection, and Surveillance: Setting Boundaries with BLyS..
J. P. Miller, J. E. Stadanlick, and M. P. Cancro (2006)
J. Immunol.
176, 6405-6410
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APRIL and BAFF Promote Increased Viability of Replicating Human B2 Cells via Mechanism Involving Cyclooxygenase 2..
P. K. A. Mongini, J. K. Inman, H. Han, R. J. Fattah, S. B. Abramson, and M. Attur (2006)
J. Immunol.
176, 6736-6751
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Constitutive NF-{kappa}B and NFAT activation leads to stimulation of the BLyS survival pathway in aggressive B-cell lymphomas.
L. Fu, Y.-C. Lin-Lee, L. V. Pham, A. Tamayo, L. Yoshimura, and R. J. Ford (2006)
Blood
107, 4540-4548
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The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL.
A. G. Brickner, A. M. Evans, J. K. Mito, S. M. Xuereb, X. Feng, T. Nishida, L. Fairfull, R. E. Ferrell, K. A. Foon, D. F. Hunt, et al. (2006)
Blood
107, 3779-3786
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Phospholipase C{gamma}2 Dosage Is Critical for B Cell Development in the Absence of Adaptor Protein BLNK..
S. Xu, J. Huo, W.-K. Chew, M. Hikida, T. Kurosaki, and K.-P. Lam (2006)
J. Immunol.
176, 4690-4698
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B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenstrom macroglobulinemia.
S. F. Elsawa, A. J. Novak, D. M. Grote, S. C. Ziesmer, T. E. Witzig, R. A. Kyle, S. R. Dillon, B. Harder, J. A. Gross, and S. M. Ansell (2006)
Blood
107, 2882-2888
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A Role for B Cell-Activating Factor of the TNF Family in Chemically Induced Autoimmunity.
Y. Zheng, S. Gallucci, J. P. Gaughan, J. A. Gross, and M. Monestier (2005)
J. Immunol.
175, 6163-6168
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C. H. Yang, A. Murti, and L. M. Pfeffer (2005)
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|Abstract »|Full Text »|PDF »
B Cell Maturation Antigen, the Receptor for a Proliferation-Inducing Ligand and B Cell-Activating Factor of the TNF Family, Induces Antigen Presentation in B Cells.
M. Yang, H. Hase, D. Legarda-Addison, L. Varughese, B. Seed, and A. T. Ting (2005)
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