Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Subscribe

Logo for

Science 293 (5537): 2111-2114

Copyright © 2001 by the American Association for the Advancement of Science

An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway

Barbara Schiemann,* Jennifer L. Gommerman, Kalpit Vora, Teresa G. Cachero, Svetlana Shulga-Morskaya, Max Dobles, Erica Frew, Martin L. Scottdagger

The B cell activating factor BAFF (BlyS/TALL-1/zTNF4) is a tumor necrosis factor (TNF)-related ligand that promotes B cell survival and binds to three receptors (BCMA, TACI, and the recently described BAFF-R). Here we report an absolute requirement for BAFF in normal B cell development. Examination of secondary lymphoid organs from BAFF-deficient mice revealed an almost complete loss of follicular and marginal zone B lymphocytes. In contrast, mice lacking BCMA had normal-appearing B lymphocyte compartments. BAFF therefore plays a crucial role in B cell development and can function through receptors other than BCMA.

Biogen, 14 Cambridge Center, Cambridge, MA 02142, USA.
*   Present address: National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA.

dagger    To whom correspondence should be addressed. E-mail: martin_scott{at}biogen.com

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Elevated serum BAFF levels in patients with sarcoidosis: association with disease activity.
I. Ueda-Hayakawa, H. Tanimura, M. Osawa, H. Iwasaka, S. Ohe, F. Yamazaki, K. Mizuno, and H. Okamoto (2013)
Rheumatology
   Abstract »    Full Text »    PDF »
B-cell Maturation Antigen Is a Promising Target for Adoptive T-cell Therapy of Multiple Myeloma.
R. O. Carpenter, M. O. Evbuomwan, S. Pittaluga, J. J. Rose, M. Raffeld, S. Yang, R. E. Gress, F. T. Hakim, and J. N. Kochenderfer (2013)
Clin. Cancer Res. 19, 2048-2060
   Abstract »    Full Text »    PDF »
The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain.
J. Schneppenheim, R. Dressel, S. Huttl, R. Lullmann-Rauch, M. Engelke, K. Dittmann, J. Wienands, E.-L. Eskelinen, I. Hermans-Borgmeyer, R. Fluhrer, et al. (2013)
J. Exp. Med. 210, 41-58
   Abstract »    Full Text »    PDF »
Global analysis of B cell selection using an immunoglobulin light chain-mediated model of autoreactivity.
S. F. Andrews, Q. Zhang, S. Lim, L. Li, J.-H. Lee, N.-Y. Zheng, M. Huang, W. M. Taylor, A. D. Farris, D. Ni, et al. (2013)
J. Exp. Med. 210, 125-142
   Abstract »    Full Text »    PDF »
Critical Role of B Cell Lymphoma 10 in BAFF-Regulated NF-{kappa}B Activation and Survival of Anergic B Cells.
M. Yu, Y. Chen, Y. He, A. Podd, G. Fu, J. A. Wright, E. Kleiman, W. N. Khan, R. Wen, and D. Wang (2012)
J. Immunol. 189, 5185-5193
   Abstract »    Full Text »    PDF »
Critical role of the IgM Fc receptor in IgM homeostasis, B-cell survival, and humoral immune responses.
R. Ouchida, H. Mori, K. Hase, H. Takatsu, T. Kurosaki, T. Tokuhisa, H. Ohno, and J.-Y. Wang (2012)
PNAS 109, E2699-E2706
   Abstract »    Full Text »    PDF »
BLyS-Mediated Modulation of Naive B Cell Subsets Impacts HIV Env-Induced Antibody Responses.
P. Dosenovic, M. Soldemo, J. L. Scholz, S. O'Dell, E. K. Grasset, N. Pelletier, M. C. I. Karlsson, J. R. Mascola, R. T. Wyatt, M. P. Cancro, et al. (2012)
J. Immunol. 188, 6018-6026
   Abstract »    Full Text »    PDF »
Essential Role for CAML in Follicular B Cell Survival and Homeostasis.
N. A. Zane, J. H. Gundelach, L. D. Lindquist, and R. J. Bram (2012)
J. Immunol. 188, 3009-3018
   Abstract »    Full Text »    PDF »
CD19+CD5+ Cells as Indicators of Preeclampsia.
F. Jensen, G. Wallukat, F. Herse, O. Budner, T. El-Mousleh, S.-D. Costa, R. Dechend, and A. C. Zenclussen (2012)
Hypertension 59, 861-868
   Abstract »    Full Text »    PDF »
BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation.
F. M. Wensveen, I. A. M. Derks, K. P. J. M. van Gisbergen, A. M. de Bruin, J. C. M. Meijers, H. Yigittop, M. A. Nolte, E. Eldering, and R. A. W. van Lier (2012)
Blood 119, 1440-1449
   Abstract »    Full Text »    PDF »
Innate Response Activator B Cells Protect Against Microbial Sepsis.
P. J. Rauch, A. Chudnovskiy, C. S. Robbins, G. F. Weber, M. Etzrodt, I. Hilgendorf, E. Tiglao, J.-L. Figueiredo, Y. Iwamoto, I. Theurl, et al. (2012)
Science 335, 597-601
   Abstract »    Full Text »    PDF »
Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey.
B. B. Aggarwal, S. C. Gupta, and J. H. Kim (2012)
Blood 119, 651-665
   Abstract »    Full Text »    PDF »
Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival.
J. Zikherman, K. Doan, R. Parameswaran, W. Raschke, and A. Weiss (2012)
PNAS 109, E3-E12
   Abstract »    Full Text »    PDF »
Belimumab in systemic lupus erythematosus: an update for clinicians.
S. S. Kim, K. A. Kirou, and D. Erkan (2012)
Therapeutic Advances in Chronic Disease 3, 11-23
   Abstract »    PDF »
Soluble BAFF Levels Inversely Correlate with Peripheral B Cell Numbers and the Expression of BAFF Receptors.
M. Kreuzaler, M. Rauch, U. Salzer, J. Birmelin, M. Rizzi, B. Grimbacher, A. Plebani, V. Lougaris, I. Quinti, V. Thon, et al. (2012)
J. Immunol. 188, 497-503
   Abstract »    Full Text »    PDF »
PI3K{delta} Inhibitors in Cancer: Rationale and Serendipity Merge in the Clinic.
D. A. Fruman and C. Rommel (2011)
Cancer Discovery 1, 562-572
   Abstract »    Full Text »    PDF »
Formation of B-1 B Cells from Neonatal B-1 Transitional Cells Exhibits NF-{kappa}B Redundancy.
E. Montecino-Rodriguez and K. Dorshkind (2011)
J. Immunol. 187, 5712-5719
   Abstract »    Full Text »    PDF »
The Long-Term Survival Potential of Mature T Lymphocytes Is Programmed During Development in the Thymus.
C. Sinclair, M. Saini, I. Schim van der Loeff, S. Sakaguchi, and B. Seddon (2011)
Science Signaling 4, ra77
   Abstract »    Full Text »    PDF »
B-cell-activating factor in rituximab-treated patients with anti-MAG polyneuropathy.
L. Benedetti, E. Zardini, C. Briani, A. Beronio, S. Gastaldi, S. Jarius, G. L. Mancardi, A. Schenone, and D. Franciotta (2011)
J. Neurol. Neurosurg. Psychiatry 82, 1291-1294
   Abstract »    Full Text »    PDF »
Chronic B Cell Deficiency from Birth Prevents Age-Related Alterations in the B Lineage.
Z. Keren, D. Averbuch, G. Shahaf, S. Zisman-Rozen, K. Golan, T. Itkin, T. Lapidot, R. Mehr, and D. Melamed (2011)
J. Immunol. 187, 2140-2147
   Abstract »    Full Text »    PDF »
Activation-induced cytidine deaminase (AID) is required for B-cell tolerance in humans.
G. Meyers, Y.-S. Ng, J. M. Bannock, A. Lavoie, J. E. Walter, L. D. Notarangelo, S. S. Kilic, G. Aksu, M. Debre, F. Rieux-Laucat, et al. (2011)
PNAS 108, 11554-11559
   Abstract »    Full Text »    PDF »
CIN85 drives B cell responses by linking BCR signals to the canonical NF-{kappa}B pathway.
K. Kometani, T. Yamada, Y. Sasaki, T. Yokosuka, T. Saito, K. Rajewsky, M. Ishiai, M. Hikida, and T. Kurosaki (2011)
J. Exp. Med. 208, 1447-1457
   Abstract »    Full Text »    PDF »
Multiple sclerosis: BAFF and CXCL13 in cerebrospinal fluid.
S. Ragheb, Y. Li, K. Simon, S. VanHaerents, D. Galimberti, M. De Riz, C. Fenoglio, E. Scarpini, and R. Lisak (2011)
Multiple Sclerosis Journal 17, 819-829
   Abstract »    Full Text »    PDF »
Cellular Competition Independent of BAFF/B Lymphocyte Stimulator Results in Low Frequency of an Autoreactive Clonotype in Mature Polyclonal B Cell Compartments.
N. Nikbakht, T.-S. Migone, C. P. Ward, and T. Manser (2011)
J. Immunol. 187, 37-46
   Abstract »    Full Text »    PDF »
B Cell Maturation Antigen Deficiency Exacerbates Lymphoproliferation and Autoimmunity in Murine Lupus.
C. Jiang, W. M. Loo, E. J. Greenley, K. S. Tung, and L. D. Erickson (2011)
J. Immunol. 186, 6136-6147
   Abstract »    Full Text »    PDF »
Somatically Diversified and Proliferating Transitional B Cells: Implications for Peripheral B Cell Homeostasis.
V. A. Yeramilli and K. L. Knight (2011)
J. Immunol. 186, 6437-6444
   Abstract »    Full Text »    PDF »
Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response.
S. Gardam, V. M. Turner, H. Anderton, S. Limaye, A. Basten, F. Koentgen, D. L. Vaux, J. Silke, and R. Brink (2011)
Blood 117, 4041-4051
   Abstract »    Full Text »    PDF »
Increased Expression of B Cell Activation Factor Supports the Abnormal Expansion of Transitional B Cells in Systemic Lupus Erythematosus.
C. LANDOLT-MARTICORENA, R. WITHER, H. REICH, A. HERZENBERG, J. SCHOLEY, D. D. GLADMAN, M. B. UROWITZ, P. R. FORTIN, and J. WITHER (2011)
J Rheumatol 38, 642-651
   Abstract »    Full Text »    PDF »
A BAFF-R mutation associated with non-Hodgkin lymphoma alters TRAF recruitment and reveals new insights into BAFF-R signaling.
J. M. Hildebrand, Z. Luo, M. K. Manske, T. Price-Troska, S. C. Ziesmer, W. Lin, B. S. Hostager, S. L. Slager, T. E. Witzig, S. M. Ansell, et al. (2010)
J. Exp. Med. 207, 2569-2579
   Abstract »    Full Text »    PDF »
Expressions of BAFF/BAFF receptors and their correlation with disease activity in Chinese SLE patients.
L. Zhao, Y. Li, M. Smith Jr, J. Wang, W. Zhang, F. Tang, X. Tian, H. Wang, F. Zhang, D. Ba, et al. (2010)
Lupus 19, 1534-1549
   Abstract »    PDF »
BAFF Receptor Signaling Aids the Differentiation of Immature B Cells into Transitional B Cells following Tonic BCR Signaling.
S. L. Rowland, K. F. Leahy, R. Halverson, R. M. Torres, and R. Pelanda (2010)
J. Immunol. 185, 4570-4581
   Abstract »    Full Text »    PDF »
Regulation of the B Cell Receptor Repertoire and Self-Reactivity by BAFF.
M. Ota, B. H. Duong, A. Torkamani, C. M. Doyle, A. L. Gavin, T. Ota, and D. Nemazee (2010)
J. Immunol. 185, 4128-4136
   Abstract »    Full Text »    PDF »
c-Met and Its Ligand Hepatocyte Growth Factor/Scatter Factor Regulate Mature B Cell Survival in a Pathway Induced by CD74.
M. Gordin, M. Tesio, S. Cohen, Y. Gore, F. Lantner, L. Leng, R. Bucala, and I. Shachar (2010)
J. Immunol. 185, 2020-2031
   Abstract »    Full Text »    PDF »
B-cell homeostasis requires complementary CD22 and BLyS/BR3 survival signals.
S. H. Smith, K. M. Haas, J. C. Poe, K. Yanaba, C. D. Ward, T.-S. Migone, and T. F. Tedder (2010)
Int. Immunol. 22, 681-691
   Abstract »    Full Text »    PDF »
The Structure of the TNFRSF13C Promoter Enables Differential Expression of BAFF-R during B Cell Ontogeny and Terminal Differentiation.
S. A. Mihalcik, P. M. Huddleston III, X. Wu, and D. F. Jelinek (2010)
J. Immunol. 185, 1045-1054
   Abstract »    Full Text »    PDF »
The Adaptor Molecule Act1 Regulates BAFF Responsiveness and Self-Reactive B Cell Selection during Transitional B Cell Maturation.
N. V. Giltiay, Y. Lu, D. Allman, T. N. Jorgensen, and X. Li (2010)
J. Immunol. 185, 99-109
   Abstract »    Full Text »    PDF »
A Functional Receptor for B-Cell-Activating Factor Is Expressed on Human Acute Lymphoblastic Leukemias.
R. Parameswaran, M. Muschen, Y.-m. Kim, J. Groffen, and N. Heisterkamp (2010)
Cancer Res. 70, 4346-4356
   Abstract »    Full Text »    PDF »
Requirement for BAFF and APRIL during B Cell Development in GALT.
V. A. Yeramilli and K. L. Knight (2010)
J. Immunol. 184, 5527-5536
   Abstract »    Full Text »    PDF »
TLR4 Promotes B Cell Maturation: Independence and Cooperation with B Lymphocyte-Activating Factor.
E. A. Hayashi, A. Granato, L. S. Paiva, A. L. Bertho, M. Bellio, and A. Nobrega (2010)
J. Immunol. 184, 4662-4672
   Abstract »    Full Text »    PDF »
Peripheral B Cell Tolerance and Function in Transgenic Mice Expressing an IgD Superantigen.
B. H. Duong, T. Ota, D. Ait-Azzouzene, M. Aoki-Ota, J. L. Vela, C. Huber, K. Walsh, A. L. Gavin, and D. Nemazee (2010)
J. Immunol. 184, 4143-4158
   Abstract »    Full Text »    PDF »
Cutting Edge: Novel Function of B Cell-Activating Factor in the Induction of IL-10-Producing Regulatory B Cells.
M. Yang, L. Sun, S. Wang, K.-H. Ko, H. Xu, B.-J. Zheng, X. Cao, and L. Lu (2010)
J. Immunol. 184, 3321-3325
   Abstract »    Full Text »    PDF »
Secreted IgM Enhances B Cell Receptor Signaling and Promotes Splenic but Impairs Peritoneal B Cell Survival.
C. A. Notley, N. Baker, and M. R. Ehrenstein (2010)
J. Immunol. 184, 3386-3393
   Abstract »    Full Text »    PDF »
Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells.
S. Suryani, D. A. Fulcher, B. Santner-Nanan, R. Nanan, M. Wong, P. J. Shaw, J. Gibson, A. Williams, and S. G. Tangye (2010)
Blood 115, 519-529
   Abstract »    Full Text »    PDF »
B-cell follicle development remodels the conduit system and allows soluble antigen delivery to follicular dendritic cells.
M. Bajenoff and R. N. Germain (2009)
Blood 114, 4989-4997
   Abstract »    Full Text »    PDF »
Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets.
M. W. Tusche, L. A. Ward, F. Vu, D. McCarthy, M. Quintela-Fandino, J. Ruland, J. L. Gommerman, and T. W. Mak (2009)
J. Exp. Med. 206, 2671-2683
   Abstract »    Full Text »    PDF »
Absence of Mature Peripheral B Cell Populations in Mice with Concomitant Defects in B Cell Receptor and BAFF-R Signaling.
K. L. Hoek, G. Carlesso, E. S. Clark, and W. N. Khan (2009)
J. Immunol. 183, 5630-5643
   Abstract »    Full Text »    PDF »
Modulation of the allergic asthma transcriptome following resiquimod treatment.
P. Camateros, C. Kanagaratham, J. Henri, R. Sladek, T. J. Hudson, and D. Radzioch (2009)
Physiol Genomics 38, 303-318
   Abstract »    Full Text »    PDF »
Functional implication of BAFF synthesis and release in gangliosides-stimulated microglia.
K. S. Kim, J.-Y. Park, I. Jou, and S. M. Park (2009)
J. Leukoc. Biol. 86, 349-359
   Abstract »    Full Text »    PDF »
Expression of B-Cell Activating Factor Enhances Protective Immunity of a Vaccine against Pseudomonas aeruginosa.
C. Tertilt, J. Joh, A. Krause, P. Chou, K. Schneeweiss, R. G. Crystal, and S. Worgall (2009)
Infect. Immun. 77, 3044-3055
   Abstract »    Full Text »    PDF »
CD4+CD25+ T-Cells Control Autoimmunity in the Absence of B-Cells.
E. Marino, J. Villanueva, S. Walters, D. Liuwantara, F. Mackay, and S. T. Grey (2009)
Diabetes 58, 1568-1577
   Abstract »    Full Text »    PDF »
B Cell Receptor-Mediated Sustained c-Rel Activation Facilitates Late Transitional B Cell Survival through Control of B Cell Activating Factor Receptor and NF-{kappa}B2.
I. Castro, J. A. Wright, B. Damdinsuren, K. L. Hoek, G. Carlesso, N. P. Shinners, R. M. Gerstein, R. T. Woodland, R. Sen, and W. N. Khan (2009)
J. Immunol. 182, 7729-7737
   Abstract »    Full Text »    PDF »
Future targets in the management of systemic sclerosis.
A. Tyndall, M. Matucci-Cerinic, and U. Muller-Ladner (2009)
Rheumatology 48, iii49-iii53
   Abstract »    Full Text »    PDF »
The proteoglycan (heparan sulfate proteoglycan) binding domain of APRIL serves as a platform for ligand multimerization and cross-linking.
F. C. Kimberley, L. van Bostelen, K. Cameron, G. Hardenberg, J. A. Marquart, M. Hahne, and J. P. Medema (2009)
FASEB J 23, 1584-1595
   Abstract »    Full Text »    PDF »
High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation.
J. A. Burger, M. P. Quiroga, E. Hartmann, A. Burkle, W. G. Wierda, M. J. Keating, and A. Rosenwald (2009)
Blood 113, 3050-3058
   Abstract »    Full Text »    PDF »
Fc{gamma}RIIB signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation.
J. E. Crowley, J. E. Stadanlick, J. C. Cambier, and M. P. Cancro (2009)
Blood 113, 1464-1473
   Abstract »    Full Text »    PDF »
Increased CD4+Foxp3+ T Cells in BAFF-Transgenic Mice Suppress T Cell Effector Responses.
S. Walters, K. E. Webster, A. Sutherland, S. Gardam, J. Groom, D. Liuwantara, E. Marino, J. Thaxton, A. Weinberg, F. Mackay, et al. (2009)
J. Immunol. 182, 793-801
   Abstract »    Full Text »    PDF »
BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact.
J. L. Scholz, J. E. Crowley, M. M. Tomayko, N. Steinel, P. J. O'Neill, W. J. Quinn III, R. Goenka, J. P. Miller, Y. H. Cho, V. Long, et al. (2008)
PNAS 105, 15517-15522
   Abstract »    Full Text »    PDF »
BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells.
K. L. Otipoby, Y. Sasaki, M. Schmidt-Supprian, A. Patke, R. Gareus, M. Pasparakis, A. Tarakhovsky, and K. Rajewsky (2008)
PNAS 105, 12435-12438
   Abstract »    Full Text »    PDF »
Immune Opsonins Modulate BLyS/BAFF Release in a Receptor-Specific Fashion.
X. Li, K. Su, C. Ji, A. J. Szalai, J. Wu, Y. Zhang, T. Zhou, R. P. Kimberly, and J. C. Edberg (2008)
J. Immunol. 181, 1012-1018
   Abstract »    Full Text »    PDF »
Global T Cell Dysregulation in Non-Autoimmune-Prone Mice Promotes Rapid Development of BAFF-Independent, Systemic Lupus Erythematosus-Like Autoimmunity.
W. Stohl, N. Jacob, W. J. Quinn III, M. P. Cancro, H. Gao, C. Putterman, X. Gao, L. Pricop, and M. N. Koss (2008)
J. Immunol. 181, 833-841
   Abstract »    Full Text »    PDF »
Sheepish B cells: evidence for antigen-independent antibody diversification in humans and mice.
D. Tarlinton (2008)
J. Exp. Med. 205, 1251-1254
   Abstract »    Full Text »    PDF »
TGF-{beta}1 and IFN-{gamma} stimulate mouse macrophages to express BAFF via different signaling pathways.
H.-A Kim, S.-H. Jeon, G.-Y. Seo, J.-B. Park, and P.-H. Kim (2008)
J. Leukoc. Biol. 83, 1431-1439
   Abstract »    Full Text »    PDF »
BAFF enhances chemotaxis of primary human B cells: a particular synergy between BAFF and CXCL13 on memory B cells.
G. Badr, G. Borhis, E. A. Lefevre, N. Chaoul, F. Deshayes, V. Dessirier, G. Lapree, A. Tsapis, and Y. Richard (2008)
Blood 111, 2744-2754
   Abstract »    Full Text »    PDF »
Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation.
A. Meyer-Bahlburg, S. F. Andrews, K. O.A. Yu, S. A. Porcelli, and D. J. Rawlings (2008)
J. Exp. Med. 205, 155-168
   Abstract »    Full Text »    PDF »
The Effect of Deleting p110{delta} on the Phenotype and Function of PTEN-Deficient B Cells.
M. L. Janas, D. Hodson, Z. Stamataki, S. Hill, K. Welch, L. Gambardella, L. C. Trotman, P. P. Pandolfi, E. Vigorito, and M. Turner (2008)
J. Immunol. 180, 739-746
   Abstract »    Full Text »    PDF »
Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival.
R. T. Woodland, C. J. Fox, M. R. Schmidt, P. S. Hammerman, J. T. Opferman, S. J. Korsmeyer, D. M. Hilbert, and C. B. Thompson (2008)
Blood 111, 750-760
   Abstract »    Full Text »    PDF »
CD74 induces TAp63 expression leading to B-cell survival.
F. Lantner, D. Starlets, Y. Gore, L. Flaishon, A. Yamit-Hezi, R. Dikstein, L. Leng, R. Bucala, Y. Machluf, M. Oren, et al. (2007)
Blood 110, 4303-4311
   Abstract »    Full Text »    PDF »
Regulated Expression of BAFF-Binding Receptors during Human B Cell Differentiation.
J. R. Darce, B. K. Arendt, X. Wu, and D. F. Jelinek (2007)
J. Immunol. 179, 7276-7286
   Abstract »    Full Text »    PDF »
In Vitro and In Vivo Activation Induces BAFF and APRIL Expression in B Cells.
V. T. Chu, P. Enghard, G. Riemekasten, and C. Berek (2007)
J. Immunol. 179, 5947-5957
   Abstract »    Full Text »    PDF »
Antibody targeting of B-cell maturation antigen on malignant plasma cells.
M. C. Ryan, M. Hering, D. Peckham, C. F. McDonagh, L. Brown, K. M. Kim, D. L. Meyer, R. F. Zabinski, I. S. Grewal, and P. J. Carter (2007)
Mol. Cancer Ther. 6, 3009-3018
   Abstract »    Full Text »    PDF »
Emerging biological therapies in primary Sjogren's syndrome.
M. Ramos-Casals and P. Brito-Zeron (2007)
Rheumatology 46, 1389-1396
   Abstract »    Full Text »    PDF »
The Recirculating B Cell Pool Contains Two Functionally Distinct, Long-Lived, Posttransitional, Follicular B Cell Populations.
A. Cariappa, C. Boboila, S. T. Moran, H. Liu, H. N. Shi, and S. Pillai (2007)
J. Immunol. 179, 2270-2281
   Abstract »    Full Text »    PDF »
TACI Is Required for Efficient Plasma Cell Differentiation in Response to T-Independent Type 2 Antigens.
G. T. Mantchev, C. S. Cortesao, M. Rebrovich, M. Cascalho, and R. J. Bram (2007)
J. Immunol. 179, 2282-2288
   Abstract »    Full Text »    PDF »
Human endometriosis is associated with plasma cells and overexpression of B lymphocyte stimulator.
A. Hever, R. B. Roth, P. Hevezi, M. E. Marin, J. A. Acosta, H. Acosta, J. Rojas, R. Herrera, D. Grigoriadis, E. White, et al. (2007)
PNAS 104, 12451-12456
   Abstract »    Full Text »    PDF »
NF-{kappa}B2 mutation targets TRAF1 to induce lymphomagenesis.
B. Zhang, Z. Wang, T. Li, E. N. Tsitsikov, and H.-F. Ding (2007)
Blood 110, 743-751
   Abstract »    Full Text »    PDF »
CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance.
M. Herve, I. Isnardi, Y.-s. Ng, J. B. Bussel, H. D. Ochs, C. Cunningham-Rundles, and E. Meffre (2007)
J. Exp. Med. 204, 1583-1593
   Abstract »    Full Text »    PDF »
Synergism between NF-{kappa}B1/p50 and Notch2 during the Development of Marginal Zone B Lymphocytes.
S. T. Moran, A. Cariappa, H. Liu, B. Muir, D. Sgroi, C. Boboila, and S. Pillai (2007)
J. Immunol. 179, 195-200
   Abstract »    Full Text »    PDF »
TLR Stimulation Modifies BLyS Receptor Expression in Follicular and Marginal Zone B Cells.
L. S. Treml, G. Carlesso, K. L. Hoek, J. E. Stadanlick, T. Kambayashi, R. J. Bram, M. P. Cancro, and W. N. Khan (2007)
J. Immunol. 178, 7531-7539
   Abstract »    Full Text »    PDF »
A primary immunodeficiency characterized by defective immunoglobulin class switch recombination and impaired DNA repair.
S. Peron, Q. Pan-Hammarstrom, K. Imai, L. Du, N. Taubenheim, O. Sanal, L. Marodi, A. Bergelin-Besancon, M. Benkerrou, J.-P. de Villartay, et al. (2007)
J. Exp. Med. 204, 1207-1216
   Abstract »    Full Text »    PDF »
Divergent Effects of BAFF on Human Memory B Cell Differentiation into Ig-Secreting Cells.
J. R. Darce, B. K. Arendt, S. K. Chang, and D. F. Jelinek (2007)
J. Immunol. 178, 5612-5622
   Abstract »    Full Text »    PDF »
The 3BP2 Adapter Protein Is Required for Optimal B-Cell Activation and Thymus-Independent Type 2 Humoral Response.
G. Chen, I. D. Dimitriou, J. La Rose, S. Ilangumaran, W.-C. Yeh, G. Doody, M. Turner, J. Gommerman, and R. Rottapel (2007)
Mol. Cell. Biol. 27, 3109-3122
   Abstract »    Full Text »    PDF »
The role of BLyS/BLyS receptors in anti-chromatin B cell regulation.
B. D. Hondowicz, S. T. Alexander, W. J. Quinn III, A. J. Pagan, M. H. Metzgar, M. P. Cancro, and J. Erikson (2007)
Int. Immunol. 19, 465-475
   Abstract »    Full Text »    PDF »
TACI regulates IgA production by APRIL in collaboration with HSPG.
D. Sakurai, H. Hase, Y. Kanno, H. Kojima, K. Okumura, and T. Kobata (2007)
Blood 109, 2961-2967
   Abstract »    Full Text »    PDF »
Generation of peripheral B cells occurs via two spatially and temporally distinct pathways.
R. C. Lindsley, M. Thomas, B. Srivastava, and D. Allman (2007)
Blood 109, 2521-2528
   Abstract »    Full Text »    PDF »
Unique and conserved functions of B cell-activating factor of the TNF family (BAFF) in the chicken.
S. Kothlow, I. Morgenroth, Y. Graef, K. Schneider, I. Riehl, P. Staeheli, P. Schneider, and B. Kaspers (2007)
Int. Immunol. 19, 203-215
   Abstract »    Full Text »    PDF »
BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-{kappa}B pathway.
T. Endo, M. Nishio, T. Enzler, H. B. Cottam, T. Fukuda, D. F. James, M. Karin, and T. J. Kipps (2007)
Blood 109, 703-710
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882