Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 293 (5538): 2263-2265

Copyright © 2001 by the American Association for the Advancement of Science

Coupling of the TCR to Integrin Activation by SLAP-130/Fyb

Erik J. Peterson,12 Melody L. Woods,5 Sally A. Dmowski,1 Geo Derimanov,12 Martha S. Jordan,1 Jennifer N. Wu,1 Peggy S. Myung,1 Qing-Hua Liu,4 Jonathan T. Pribila,5 Bruce D. Freedman,4 Yoji Shimizu,5 Gary A. Koretzky13*

SLAP-130/Fyb (SLP-76-associated phosphoprotein or Fyn-binding protein; also known as Fyb/Slap) is a hematopoietic-specific adapter, which associates with and modulates function of SH2-containing leukocyte phosphoprotein of 76 kilodaltons (SLP-76). T cells from mice lacking SLAP-130/Fyb show markedly impaired proliferation following CD3 engagement. In addition, the T cell receptor (TCR) in SLAP-130/Fyb mutant cells fails to enhance integrin-dependent adhesion. Although TCR-induced actin polymerization is normal, TCR-stimulated clustering of the integrin LFA-1 is defective in SLAP-130/Fyb-deficient cells. These data indicate that SLAP-130/Fyb is important for coupling TCR-mediated actin cytoskeletal rearrangement with activation of integrin function, and for T cells to respond fully to activating signals.

1 The Abramson Family Cancer Research Institute, Departments of
2 Medicine and
3 Pathology and Laboratory Medicine, School of Medicine, and the
4 Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
5 Department of Pathology and Laboratory Medicine, Center for Immunology, Cancer Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
*   To whom correspondence should be addressed. E-mail: koretzky{at}

The N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms.
M. J. Ophir, B. C. Liu, and S. C. Bunnell (2013)
J. Cell Biol. 203, 1021-1041
   Abstract »    Full Text »    PDF »
T Cell-Independent Modulation of Experimental Autoimmune Encephalomyelitis in ADAP-Deficient Mice.
S. Engelmann, M. Togni, A. Thielitz, P. Reichardt, S. Kliche, D. Reinhold, B. Schraven, and A. Reinhold (2013)
J. Immunol. 191, 4950-4959
   Abstract »    Full Text »    PDF »
Multipoint Binding of the SLP-76 SH2 Domain to ADAP Is Critical for Oligomerization of SLP-76 Signaling Complexes in Stimulated T Cells.
N. P. Coussens, R. Hayashi, P. H. Brown, L. Balagopalan, A. Balbo, I. Akpan, J. C. D. Houtman, V. A. Barr, P. Schuck, E. Appella, et al. (2013)
Mol. Cell. Biol. 33, 4140-4151
   Abstract »    Full Text »    PDF »
Multistage T Cell-Dendritic Cell Interactions Control Optimal CD4 T Cell Activation through the ADAP-SKAP55-Signaling Module.
J. S. Mitchell, B. J. Burbach, R. Srivastava, B. T. Fife, and Y. Shimizu (2013)
J. Immunol. 191, 2372-2383
   Abstract »    Full Text »    PDF »
Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.
R. M. May, M. Okumura, C.-J. Hsu, H. Bassiri, E. Yang, G. Rak, E. M. Mace, N. H. Philip, W. Zhang, T. Baumgart, et al. (2013)
Blood 121, 3135-3146
   Abstract »    Full Text »    PDF »
ADAP Regulates Cell Cycle Progression of T Cells via Control of Cyclin E and Cdk2 Expression through Two Distinct CARMA1-Dependent Signaling Pathways.
R. Srivastava, B. J. Burbach, J. S. Mitchell, A. J. Pagan, and Y. Shimizu (2012)
Mol. Cell. Biol. 32, 1908-1917
   Abstract »    Full Text »    PDF »
Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury.
H. Block, J. M. Herter, J. Rossaint, A. Stadtmann, S. Kliche, C. A. Lowell, and A. Zarbock (2012)
J. Exp. Med. 209, 407-421
   Abstract »    Full Text »    PDF »
CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules.
S. Kliche, T. Worbs, X. Wang, J. Degen, I. Patzak, B. Meineke, M. Togni, M. Moser, A. Reinhold, F. Kiefer, et al. (2012)
Blood 119, 777-785
   Abstract »    Full Text »    PDF »
TM4SF10 and ADAP interaction in podocytes: role in Fyn activity and nephrin phosphorylation.
T. A. Azhibekov, Z. Wu, A. Padiyar, L. A. Bruggeman, and J. S. Simske (2011)
Am J Physiol Cell Physiol 301, C1351-C1359
   Abstract »    Full Text »    PDF »
Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation.
R. Lasserre, C. Cuche, R. Blecher-Gonen, E. Libman, E. Biquand, A. Danckaert, D. Yablonski, A. Alcover, and V. Di Bartolo (2011)
J. Cell Biol. 195, 839-853
   Abstract »    Full Text »    PDF »
The SLP-76 Src Homology 2 Domain Is Required for T Cell Development and Activation.
J. C. Burns, E. Corbo, J. Degen, M. Gohil, C. Anterasian, B. Schraven, G. A. Koretzky, S. Kliche, and M. S. Jordan (2011)
J. Immunol. 187, 4459-4466
   Abstract »    Full Text »    PDF »
SKAP1 Protein PH Domain Determines RapL Membrane Localization and Rap1 Protein Complex Formation for T Cell Receptor (TCR) Activation of LFA-1.
M. Raab, X. Smith, Y. Matthess, K. Strebhardt, and C. E. Rudd (2011)
J. Biol. Chem. 286, 29663-29670
   Abstract »    Full Text »    PDF »
Impairment of Immunological Synapse Formation in Adaptively Tolerant T Cells.
S. Choi and R. H. Schwartz (2011)
J. Immunol. 187, 805-816
   Abstract »    Full Text »    PDF »
Functional Cooperation between the Proteins Nck and ADAP Is Fundamental for Actin Reorganization.
M. H. Pauker, B. Reicher, S. Fried, O. Perl, and M. Barda-Saad (2011)
Mol. Cell. Biol. 31, 2653-2666
   Abstract »    Full Text »    PDF »
The Pleckstrin Homology Domain in the SKAP55 Adapter Protein Defines the Ability of the Adapter Protein ADAP To Regulate Integrin Function and NF-{kappa}B Activation.
B. J. Burbach, R. Srivastava, M. A. Ingram, J. S. Mitchell, and Y. Shimizu (2011)
J. Immunol. 186, 6227-6237
   Abstract »    Full Text »    PDF »
Understanding the Structure and Function of the Immunological Synapse.
M. L. Dustin, A. K. Chakraborty, and A. S. Shaw (2010)
Cold Spring Harb Perspect Biol 2, a002311
   Abstract »    Full Text »    PDF »
NF-{kappa}B Activation in T Cells Requires Discrete Control of I{kappa}B Kinase {alpha}/{beta} (IKK{alpha}/{beta}) Phosphorylation and IKK{gamma} Ubiquitination by the ADAP Adapter Protein.
R. Srivastava, B. J. Burbach, and Y. Shimizu (2010)
J. Biol. Chem. 285, 11100-11105
   Abstract »    Full Text »    PDF »
An LFA-1 ({alpha}L{beta}2) Small-Molecule Antagonist Reduces Inflammation and Joint Destruction in Murine Models of Arthritis.
S. J. Suchard, D. K. Stetsko, P. M. Davis, S. Skala, D. Potin, M. Launay, T. G. M. Dhar, J. C. Barrish, V. Susulic, D. J. Shuster, et al. (2010)
J. Immunol. 184, 3917-3926
   Abstract »    Full Text »    PDF »
Role for ADAP in shear flow-induced platelet mechanotransduction.
A. Kasirer-Friede, Z. M. Ruggeri, and S. J. Shattil (2010)
Blood 115, 2274-2282
   Abstract »    Full Text »    PDF »
Src Homology 2-Domain Containing Leukocyte-Specific Phosphoprotein of 76 kDa Is Mandatory for TCR-Mediated Inside-Out Signaling, but Dispensable for CXCR4-Mediated LFA-1 Activation, Adhesion, and Migration of T Cells.
J. Horn, X. Wang, P. Reichardt, T. E. Stradal, N. Warnecke, L. Simeoni, M. Gunzer, D. Yablonski, B. Schraven, and S. Kliche (2009)
J. Immunol. 183, 5756-5767
   Abstract »    Full Text »    PDF »
The Adapter Protein SLP-76 Mediates "Outside-In" Integrin Signaling and Function in T Cells.
R. G. Baker, C. J. Hsu, D. Lee, M. S. Jordan, J. S. Maltzman, D. A. Hammer, T. Baumgart, and G. A. Koretzky (2009)
Mol. Cell. Biol. 29, 5578-5589
   Abstract »    Full Text »    PDF »
SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.
H. Wang, B. Wei, G. Bismuth, and C. E. Rudd (2009)
PNAS 106, 12436-12441
   Abstract »    Full Text »    PDF »
Expression of SKAP-HOM in DCs is required for an optimal immune response in vivo.
A. Reinhold, S. Reimann, D. Reinhold, B. Schraven, and M. Togni (2009)
J. Leukoc. Biol. 86, 61-71
   Abstract »    Full Text »    PDF »
Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells.
T. Quast, B. Tappertzhofen, C. Schild, J. Grell, N. Czeloth, R. Forster, R. Alon, L. Fraemohs, K. Dreck, C. Weber, et al. (2009)
Blood 113, 5801-5810
   Abstract »    Full Text »    PDF »
Distinct Regulation of Integrin-Dependent T Cell Conjugate Formation and NF-{kappa}B Activation by the Adapter Protein ADAP.
B. J. Burbach, R. Srivastava, R. B. Medeiros, W. E. O'Gorman, E. J. Peterson, and Y. Shimizu (2008)
J. Immunol. 181, 4840-4851
   Abstract »    Full Text »    PDF »
Regulation of integrin activation through the B-cell receptor.
E. Arana, N. E. Harwood, and F. D. Batista (2008)
J. Cell Sci. 121, 2279-2286
   Abstract »    Full Text »    PDF »
{alpha}PIX Rho GTPase Guanine Nucleotide Exchange Factor Regulates Lymphocyte Functions and Antigen Receptor Signaling.
K. Missy, B. Hu, K. Schilling, A. Harenberg, V. Sakk, K. Kuchenbecker, K. Kutsche, and K.-D. Fischer (2008)
Mol. Cell. Biol. 28, 3776-3789
   Abstract »    Full Text »    PDF »
Inverse Rap1 and Phospho-ERK Expression Discriminate the Maintenance Phase of Tolerance and Priming of Antigen-Specific CD4+ T Cells In Vitro and In Vivo.
A. M. Morton, B. McManus, P. Garside, A. McI. Mowat, and M. M. Harnett (2007)
J. Immunol. 179, 8026-8034
   Abstract »    Full Text »    PDF »
Functional Defects of SKAP-55-Deficient T Cells Identify a Regulatory Role for the Adaptor in LFA-1 Adhesion.
H. Wang, H. Liu, Y. Lu, M. Lovatt, B. Wei, and C. E. Rudd (2007)
Mol. Cell. Biol. 27, 6863-6875
   Abstract »    Full Text »    PDF »
Adhesion and Degranulation-Promoting Adapter Protein (ADAP) Positively Regulates T Cell Sensitivity to Antigen and T Cell Survival.
K. L. Mueller, M. S. Thomas, B. J. Burbach, E. J. Peterson, and Y. Shimizu (2007)
J. Immunol. 179, 3559-3569
   Abstract »    Full Text »    PDF »
WAVE2 Regulates High-Affinity Integrin Binding by Recruiting Vinculin and Talin to the Immunological Synapse.
J. C. Nolz, R. B. Medeiros, J. S. Mitchell, P. Zhu, B. D. Freedman, Y. Shimizu, and D. D. Billadeau (2007)
Mol. Cell. Biol. 27, 5986-6000
   Abstract »    Full Text »    PDF »
The Cytosolic Protein Talin Induces an Intermediate Affinity Integrin {alpha}Lbeta2.
Y.-F. Li, R.-H. Tang, K.-J. Puan, S. K. A. Law, and S.-M. Tan (2007)
J. Biol. Chem. 282, 24310-24319
   Abstract »    Full Text »    PDF »
RIAM Links the ADAP/SKAP-55 Signaling Module to Rap1, Facilitating T-Cell-Receptor-Mediated Integrin Activation.
G. Menasche, S. Kliche, E. J. H. Chen, T. E. B. Stradal, B. Schraven, and G. Koretzky (2007)
Mol. Cell. Biol. 27, 4070-4081
   Abstract »    Full Text »    PDF »
Regulation of NF-{kappa}B Activation in T Cells via Association of the Adapter Proteins ADAP and CARMA1.
R. B. Medeiros, B. J. Burbach, K. L. Mueller, R. Srivastava, J. J. Moon, S. Highfill, E. J. Peterson, and Y. Shimizu (2007)
Science 316, 754-758
   Abstract »    Full Text »    PDF »
Activating Ly-49 Receptors Regulate LFA-1-Mediated Adhesion by NK Cells.
M. S. Osman, D. N. Burshtyn, and K. P. Kane (2007)
J. Immunol. 178, 1261-1267
   Abstract »    Full Text »    PDF »
ADAP is required for normal {alpha}IIb{beta}3 activation by VWF/GP Ib-IX-V and other agonists.
A. Kasirer-Friede, B. Moran, J. Nagrampa-Orje, K. Swanson, Z. M. Ruggeri, B. Schraven, B. G. Neel, G. Koretzky, and S. J. Shattil (2007)
Blood 109, 1018-1025
   Abstract »    Full Text »    PDF »
Loss of Src Homology Region 2 Domain-Containing Protein Tyrosine Phosphatase-1 Increases CD8+ T Cell-APC Conjugate Formation and Is Associated with Enhanced In Vivo CTL Function.
J. G. Sathish, G. Dolton, F. G. LeRoy, and R. J. Matthews (2007)
J. Immunol. 178, 330-337
   Abstract »    Full Text »    PDF »
The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activation.
J.-i. Suzuki, S. Yamasaki, J. Wu, G. A. Koretzky, and T. Saito (2007)
Blood 109, 168-175
   Abstract »    Full Text »    PDF »
Talin1 Regulates TCR-Mediated LFA-1 Function.
W. T. N. Simonson, S. J. Franco, and A. Huttenlocher (2006)
J. Immunol. 177, 7707-7714
   Abstract »    Full Text »    PDF »
Recruitment of dynein to the Jurkat immunological synapse.
J. Combs, S. J. Kim, S. Tan, L. A. Ligon, E. L. F. Holzbaur, J. Kuhn, and M. Poenie (2006)
PNAS 103, 14883-14888
   Abstract »    Full Text »    PDF »
The ADAP/SKAP55 Signaling Module Regulates T-Cell Receptor-Mediated Integrin Activation through Plasma Membrane Targeting of Rap1.
S. Kliche, D. Breitling, M. Togni, R. Pusch, K. Heuer, X. Wang, C. Freund, A. Kasirer-Friede, G. Menasche, G. A. Koretzky, et al. (2006)
Mol. Cell. Biol. 26, 7130-7144
   Abstract »    Full Text »    PDF »
ADAP is dispensable for NK cell development and function.
L. V. Fostel, J. Dluzniewska, Y. Shimizu, B. J. Burbach, and E. J. Peterson (2006)
Int. Immunol. 18, 1305-1314
   Abstract »    Full Text »    PDF »
Adhesion- and Degranulation-Promoting Adapter Protein Is Required for Efficient Thymocyte Development and Selection..
J. N. Wu, S. Gheith, N. A. Bezman, Q.-H. Liu, L. V. Fostel, A. M. Swanson, B. D. Freedman, G. A. Koretzky, and E. J. Peterson (2006)
J. Immunol. 176, 6681-6689
   Abstract »    Full Text »    PDF »
Regulation and Function of SKAP-55 Non-canonical Motif Binding to the SH3c Domain of Adhesion and Degranulation-promoting Adaptor Protein.
J. S. Duke-Cohan, H. Kang, H. Liu, and C. E. Rudd (2006)
J. Biol. Chem. 281, 13743-13750
   Abstract »    Full Text »    PDF »
Rap1A-Deficient T and B Cells Show Impaired Integrin-Mediated Cell Adhesion.
M. Duchniewicz, T. Zemojtel, M. Kolanczyk, S. Grossmann, J. S. Scheele, and F. J. T. Zwartkruis (2006)
Mol. Cell. Biol. 26, 643-653
   Abstract »    Full Text »    PDF »
Protein Tyrosine Phosphatase {alpha} Regulates Fyn Activity and Cbp/PAG Phosphorylation in Thymocyte Lipid Rafts.
L. Maksumova, H. T. Le, F. Muratkhodjaev, D. Davidson, A. Veillette, and C. J. Pallen (2005)
J. Immunol. 175, 7947-7956
   Abstract »    Full Text »    PDF »
Tec Kinases Regulate TCR-Mediated Recruitment of Signaling Molecules and Integrin-Dependent Cell Adhesion.
L. D. Finkelstein, Y. Shimizu, and P. L. Schwartzberg (2005)
J. Immunol. 175, 5923-5930
   Abstract »    Full Text »    PDF »
Regulation of In Vitro and In Vivo Immune Functions by the Cytosolic Adaptor Protein SKAP-HOM.
M. Togni, K. D. Swanson, S. Reimann, S. Kliche, A. C. Pearce, L. Simeoni, D. Reinhold, J. Wienands, B. G. Neel, B. Schraven, et al. (2005)
Mol. Cell. Biol. 25, 8052-8063
   Abstract »    Full Text »    PDF »
Physical and Functional Association of c-Src and Adhesion and Degranulation Promoting Adaptor Protein (ADAP) in Osteoclastogenesis in Vitro.
S. Koga, K. Yogo, K. Yoshikawa, H. Samori, M. Goto, T. Uchida, N. Ishida, and T. Takeya (2005)
J. Biol. Chem. 280, 31564-31571
   Abstract »    Full Text »    PDF »
Receptor-stimulated oxidation of SHP-2 promotes T-cell adhesion through SLP-76-ADAP.
J. Kwon, C.-K. Qu, J.-S. Maeng, R. Falahati, C. Lee, and M. S. Williams (2005)
EMBO J. 24, 2331-2341
   Abstract »    Full Text »    PDF »
Deficiency of ADAP/Fyb/SLAP-130 Destabilizes SKAP55 in Jurkat T Cells.
Y. Huang, D. D. Norton, P. Precht, J. L. Martindale, J. K. Burkhardt, and R. L. Wange (2005)
J. Biol. Chem. 280, 23576-23583
   Abstract »    Full Text »    PDF »
Importance of integrin LFA-1 deactivation for the generation of immune responses.
M. Semmrich, A. Smith, C. Feterowski, S. Beer, B. Engelhardt, D. H. Busch, B. Bartsch, M. Laschinger, N. Hogg, K. Pfeffer, et al. (2005)
J. Exp. Med. 201, 1987-1998
   Abstract »    Full Text »    PDF »
An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R.
E.-K. Jo, H. Wang, and C. E. Rudd (2005)
J. Exp. Med. 201, 1733-1739
   Abstract »    Full Text »    PDF »
PRAM-1 Potentiates Arsenic Trioxide-induced JNK Activation.
F. M. Denis, A. Benecke, Y. Di Gioia, I. P. Touw, Y. E. Cayre, and P. G. Lutz (2005)
J. Biol. Chem. 280, 9043-9048
   Abstract »    Full Text »    PDF »
Defective Proximal TCR Signaling Inhibits CD8+ Tumor-Infiltrating Lymphocyte Lytic Function.
M. Koneru, D. Schaer, N. Monu, A. Ayala, and A. B. Frey (2005)
J. Immunol. 174, 1830-1840
   Abstract »    Full Text »    PDF »
Distinct Calcium Channels Regulate Responses of Primary B Lymphocytes to B Cell Receptor Engagement and Mechanical Stimuli.
Q.-H. Liu, X. Liu, Z. Wen, B. Hondowicz, L. King, J. Monroe, and B. D. Freedman (2005)
J. Immunol. 174, 68-79
   Abstract »    Full Text »    PDF »
PRAM-1 Is Required for Optimal Integrin-Dependent Neutrophil Function.
R. A. Clemens, S. A. Newbrough, E. Y. Chung, S. Gheith, A. L. Singer, G. A. Koretzky, and E. J. Peterson (2004)
Mol. Cell. Biol. 24, 10923-10932
   Abstract »    Full Text »    PDF »
ADAP-SLP-76 Binding Differentially Regulates Supramolecular Activation Cluster (SMAC) Formation Relative to T Cell-APC Conjugation.
H. Wang, F. E. McCann, J. D. Gordan, X. Wu, M. Raab, T. H. Malik, D. M. Davis, and C. E. Rudd (2004)
J. Exp. Med. 200, 1063-1074
   Abstract »    Full Text »    PDF »
Gene expression profiles during human CD4+ T cell differentiation.
M. S. Lee, K. Hanspers, C. S. Barker, A. P. Korn, and J. M. McCune (2004)
Int. Immunol. 16, 1109-1124
   Abstract »    Full Text »    PDF »
Differential Requirement for Adapter Proteins Src Homology 2 Domain-Containing Leukocyte Phosphoprotein of 76 kDa and Adhesion- and Degranulation-Promoting Adapter Protein in Fc{epsilon}RI Signaling and Mast Cell Function.
J. N. Wu, M. S. Jordan, M. A. Silverman, E. J. Peterson, and G. A. Koretzky (2004)
J. Immunol. 172, 6768-6774
   Abstract »    Full Text »    PDF »
The Adapter Molecule Sin Regulates T-Cell-Receptor-Mediated Signal Transduction by Modulating Signaling Substrate Availability.
L. Xing, L. T. Donlin, R. H. Miller, and K. Alexandropoulos (2004)
Mol. Cell. Biol. 24, 4581-4592
   Abstract »    Full Text »    PDF »
Control of TCR-Mediated Activation of {beta}1 Integrins by the ZAP-70 Tyrosine Kinase Interdomain B Region and the Linker for Activation of T Cells Adapter Protein.
S. Goda, A. C. Quale, M. L. Woods, A. Felthauser, and Y. Shimizu (2004)
J. Immunol. 172, 5379-5387
   Abstract »    Full Text »    PDF »
Signaling through GP Ib-IX-V activates {alpha}IIb{beta}3 independently of other receptors.
A. Kasirer-Friede, M. R. Cozzi, M. Mazzucato, L. De Marco, Z. M. Ruggeri, and S. J. Shattil (2004)
Blood 103, 3403-3411
   Abstract »    Full Text »    PDF »
Roles of the Proline-rich Domain in SLP-76 Subcellular Localization and T Cell Function.
A. L. Singer, S. C. Bunnell, A. E. Obstfeld, M. S. Jordan, J. N. Wu, P. S. Myung, L. E. Samelson, and G. A. Koretzky (2004)
J. Biol. Chem. 279, 15481-15490
   Abstract »    Full Text »    PDF »
Enrichment of Lck in Lipid Rafts Regulates Colocalized Fyn Activation and the Initiation of Proximal Signals through TCR{alpha}{beta}.
D. Filipp, B. L. Leung, J. Zhang, A. Veillette, and M. Julius (2004)
J. Immunol. 172, 4266-4274
   Abstract »    Full Text »    PDF »
Macrophage activation and Fc{gamma} receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors.
K. E. Nichols, K. Haines, P. S. Myung, S. Newbrough, E. Myers, H. Jumaa, D. J. Shedlock, H. Shen, and G. A. Koretzky (2004)
J. Leukoc. Biol. 75, 541-552
   Abstract »    Full Text »    PDF »
T-cell integrins: more than just sticking points.
N. Hogg, M. Laschinger, K. Giles, and A. McDowall (2003)
J. Cell Sci. 116, 4695-4705
   Abstract »    Full Text »    PDF »
Developmental markers of B cells are superior to those of T cells for identification of stages with distinct gene expression profiles.
R. Hoffmann, T. Seidl, L. Bruno, and M. Dugas (2003)
J. Leukoc. Biol. 74, 602-610
   Abstract »    Full Text »    PDF »
The {beta}1 and {beta}3 Integrins Promote T Cell Receptor-mediated Cytotoxic T Lymphocyte Activation.
M.-A. Doucey, D. F. Legler, M. Faroudi, N. Boucheron, P. Baumgaertner, D. Naeher, M. Cebecauer, D. Hudrisier, C. Ruegg, E. Palmer, et al. (2003)
J. Biol. Chem. 278, 26983-26991
   Abstract »    Full Text »    PDF »
Distinct Role of ZAP-70 and Src Homology 2 Domain-Containing Leukocyte Protein of 76 kDa in the Prolonged Activation of Extracellular Signal-Regulated Protein Kinase by the Stromal Cell-Derived Factor-1{alpha}/CXCL12 Chemokine.
K. N. Kremer, T. D. Humphreys, A. Kumar, N.-X. Qian, and K. E. Hedin (2003)
J. Immunol. 171, 360-367
   Abstract »    Full Text »    PDF »
Structural Requirements of SLP-76 in Signaling via the High-Affinity Immunoglobulin E Receptor (Fc{varepsilon}RI) in Mast Cells.
A. Kettner, V. Pivniouk, L. Kumar, H. Falet, J.-S. Lee, R. Mulligan, and R. S. Geha (2003)
Mol. Cell. Biol. 23, 2395-2406
   Abstract »    Full Text »    PDF »
Presentation of Antigen by Endothelial Cells and Chemoattraction Are Required for Homing of Insulin-specific CD8+ T Cells.
A. Y. Savinov, F. S. Wong, A. C. Stonebraker, and A. V. Chervonsky (2003)
J. Exp. Med. 197, 643-656
   Abstract »    Full Text »    PDF »
{beta}1/{beta}3 integrin ligation is uncoupled from ERK1/ERK2 activation in cytotoxic T lymphocytes.
L. G. Puente and H. L. Ostergaard (2003)
J. Leukoc. Biol. 73, 391-398
   Abstract »    Full Text »    PDF »
Differential recruitment of {alpha}2{beta}1 and {alpha}4{beta}1 integrins to lipid rafts in Jurkat T lymphocytes exposed to collagen type IV and fibronectin.
B. J. Holleran, E. Barbar, M. D. Payet, and G. Dupuis (2003)
J. Leukoc. Biol. 73, 243-252
   Abstract »    Full Text »    PDF »
Beyond calcium: new signaling pathways for Tec family kinases.
A. Takesono, L. D. Finkelstein, and P. L. Schwartzberg (2002)
J. Cell Sci. 115, 3039-3048
   Abstract »    Full Text »    PDF »
ADAP-ting TCR Signaling to Integrins.
E. K. Griffiths and J. M. Penninger (2002)
Sci. STKE 2002, re3
   Abstract »    Full Text »    PDF »
Cutting Edge: Differential Segregation of the Src Homology 2-Containing Protein Tyrosine Phosphatase-1 Within the Early NK Cell Immune Synapse Distinguishes Noncytolytic from Cytolytic Interactions.
Y. M. Vyas, H. Maniar, and B. Dupont (2002)
J. Immunol. 168, 3150-3154
   Abstract »    Full Text »    PDF »
Differential Requirement for LAT and SLP-76 in GPVI versus T Cell Receptor Signaling.
B. A. Judd, P. S. Myung, A. Obergfell, E. E. Myers, A. M. Cheng, S. P. Watson, W. S. Pear, D. Allman, S. J. Shattil, and G. A. Koretzky (2002)
J. Exp. Med. 195, 705-717
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882