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Science 293 (5538): 2269-2271
Copyright © 2001 by the American Association for the Advancement of Science
A Role for the RNase III Enzyme DCR-1 in RNA Interference and Germ Line Development in Caenorhabditis elegans
Scott W. Knight,
Brenda L. Bass*
An early event in RNA interference (RNAi) is the
cleavage of the initiating double-stranded RNA (dsRNA) to short pieces,
21 to 23 nucleotides in length. Here we describe a null mutation in
dicer-1 (dcr-1), a gene proposed to encode the
enzyme that generates these short RNAs. We find that
dcr-1( / ) animals have defects in RNAi under some, but
not all, conditions. Mutant animals have germ line defects that lead to
sterility, suggesting that cleavage of dsRNA to short pieces is a
requisite event in normal development.
Department of Biochemistry and Howard Hughes Medical Institute,
University of Utah, 50 North Medical Drive, Room 211, Salt Lake City,
UT 84132, USA.
*
To whom correspondence should be addressed. E-mail:
bbass{at}howard.genetics.utah.edu
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