Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice
Marek Drab,12Paul Verkade,1Marlies Elger,3Michael Kasper,4Matthias Lohn,23Birgit Lauterbach,23Jan Menne,3Carsten Lindschau,23Fanny Mende,1Friedrich C. Luft,2Andreas Schedl,5Hermann Haller,3Teymuras V. Kurzchalia1*
Caveolae are plasma membrane invaginations that may play an
important role in numerous cellular processes including transport,signaling, and tumor suppression. By targeted disruption of caveolin-1,the main protein component of caveolae, we generated mice thatlacked
caveolae. The absence of this organelle impaired nitricoxide and
calcium signaling in the cardiovascular system, causingaberrations in
endothelium-dependent relaxation, contractility,and maintenance of
myogenic tone. In addition, the lungs of knockoutanimals displayed
thickening of alveolar septa caused by uncontrolledendothelial cell
proliferation and fibrosis, resulting in severephysical
limitations in caveolin-1-disrupted mice. Thus, caveolin-1and
caveolae play a fundamental role in organizing multiple signalingpathways in the cell.
1 Max Planck Institute for Molecular Cell
Biology and Genetics, Pfotenhauer-Strasse 108, D-01307 Dresden,
Germany.
2 Franz Volhard Clinic and
Max-Delbrück-Center for Molecular Medicine, Humboldt University
Berlin, Wiltberg-Strasse 50, D-13125 Berlin, Germany.
3 Hannover Medical School, Karl-Neuberg-Strasse 1, D-30625 Hannover, Germany.
4 Institute of Anatomy,
Technical University of Dresden, Fetscher-Strasse 74, D-01307 Dresden,
Germany.
5 Max-Delbrück-Center for Molecular
Medicine, Robert-Roessle-Strasse 10, D-13125 Berlin, Germany.
*
To whom correspondence should be addressed. E-mail:
kurzchalia{at}mpi-cbg.de
The editors suggest the following Related Resources on Science sites:
In Science Magazine
PERSPECTIVES
Robert G. Parton (28 September 2001) Science293 (5539), 2404.
[DOI: 10.1126/science.1065677] |Summary »|Full Text »|PDF »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Flow detection and calcium signalling in vascular endothelial cells.
A potential role for caveolin-1 in VEGF-induced fibronectin upregulation in mesangial cells: involvement of VEGFR2 and Src.
T. Wu, B. Zhang, F. Ye, and Z. Xiao (2013)
Am J Physiol Renal Physiol
304, F820-F830
|Abstract »|Full Text »|PDF »
Deletion of integrin linked kinase in endothelial cells results in defective RTK signaling caused by caveolin 1 mislocalization.
D. Malan, A. Elischer, M. Hesse, S. A. Wickstrom, B. K. Fleischmann, and W. Bloch (2013)
Development
140, 987-995
|Abstract »|Full Text »|PDF »
Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells.
B. S. J. Davies, C. N. Goulbourne, R. H. Barnes II, K. A. Turlo, P. Gin, S. Vaughan, D. J. Vaux, A. Bensadoun, A. P. Beigneux, L. G. Fong, et al. (2012)
J. Lipid Res.
53, 2690-2697
|Abstract »|Full Text »|PDF »
RhoA localization with caveolin-1 regulates vascular contractions to serotonin.
D. W. Nuno, S. K. England, and K. G. Lamping (2012)
Am J Physiol Regulatory Integrative Comp Physiol
303, R959-R967
|Abstract »|Full Text »|PDF »
B. Aravamudan, S. K. VanOosten, L. W. Meuchel, P. Vohra, M. Thompson, G. C. Sieck, Y. S. Prakash, and C. M. Pabelick (2012)
Am J Physiol Lung Cell Mol Physiol
303, L669-L681
|Abstract »|Full Text »|PDF »
Apolipoprotein E Enhances Endothelial-NO Production by Modulating Caveolin 1 Interaction With Endothelial NO Synthase * Novelty and Significance.
L. Yue, J.-T. Bian, I. Grizelj, A. Cavka, S. A. Phillips, A. Makino, and T. Mazzone (2012)
Hypertension
60, 1040-1046
|Abstract »|Full Text »|PDF »
L. Feng, H.-h. Zhang, W. Wang, J. Zheng, and D.-b. Chen (2012)
Biol Reprod
87, 40
|Abstract »|Full Text »|PDF »
Evidence for the Nitric Oxide Pathway as a Potential Mode of Action in Fenoldopam-induced Vascular Injury.
D. A. Brott, R. J. Richardson, and C. S. Louden (2012)
Toxicol Pathol
40, 874-886
|Abstract »|Full Text »|PDF »
Tetraspanin CD151 Protects against Pulmonary Fibrosis by Maintaining Epithelial Integrity.
K. Tsujino, Y. Takeda, T. Arai, Y. Shintani, R. Inagaki, H. Saiga, T. Iwasaki, S. Tetsumoto, Y. Jin, S. Ihara, et al. (2012) 186, 170-180
|Abstract »|Full Text »|PDF »
Caveolin-1 Deficiency Protects from Pulmonary Fibrosis by Modulating Epithelial Cell Senescence in Mice.
P. Shivshankar, C. Brampton, S. Miyasato, M. Kasper, V. J. Thannickal, and C. J. Le Saux (2012) 47, 28-36
|Abstract »|Full Text »|PDF »
Chronic hypoxia induces right heart failure in caveolin-1-/- mice.
J. A. Cruz, E. M. Bauer, A. I. Rodriguez, A. Gangopadhyay, N. S. Zeineh, Y. Wang, S. Shiva, H. C. Champion, and P. M. Bauer (2012)
Am J Physiol Heart Circ Physiol
302, H2518-H2527
|Abstract »|Full Text »|PDF »
Interaction with Caveolin-1 Modulates G Protein Coupling of Mouse {beta}3-Adrenoceptor.
M. Sato, D. S. Hutchinson, M. L. Halls, S. G. B. Furness, T. Bengtsson, B. A. Evans, and R. J. Summers (2012)
J. Biol. Chem.
287, 20674-20688
|Abstract »|Full Text »|PDF »
Whole Exome Sequencing to Identify a Novel Gene (Caveolin-1) Associated With Human Pulmonary Arterial Hypertension.
E. D. Austin, L. Ma, C. LeDuc, E. Berman Rosenzweig, A. Borczuk, J. A. Phillips III, T. Palomero, P. Sumazin, H. R. Kim, M. H. Talati, et al. (2012)
Circ Cardiovasc Genet
5, 336-343
|Abstract »|Full Text »|PDF »
Loss of Caveolin-1 Impairs Retinal Function Due to Disturbance of Subretinal Microenvironment.
X. Li, M. E. McClellan, M. Tanito, P. Garteiser, R. Towner, D. Bissig, B. A. Berkowitz, S. J. Fliesler, M. L. Woodruff, G. L. Fain, et al. (2012)
J. Biol. Chem.
287, 16424-16434
|Abstract »|Full Text »|PDF »
A Membrane Microdomain-Associated Protein, Arabidopsis Flot1, Is Involved in a Clathrin-Independent Endocytic Pathway and Is Required for Seedling Development.
R. Li, P. Liu, Y. Wan, T. Chen, Q. Wang, U. Mettbach, F. Baluska, J. Samaj, X. Fang, W. J. Lucas, et al. (2012)
PLANT CELL
24, 2105-2122
|Abstract »|Full Text »|PDF »
Molecular assembly and dynamics of fluorescent protein-tagged single KCa1.1 channel in expression system and vascular smooth muscle cells.
H. Yamamura, C. Ikeda, Y. Suzuki, S. Ohya, and Y. Imaizumi (2012)
Am J Physiol Cell Physiol
302, C1257-C1268
|Abstract »|Full Text »|PDF »
Hyperoxia-Induced LC3B Interacts with the Fas Apoptotic Pathway in Epithelial Cell Death.
A. Tanaka, Y. Jin, S.-J. Lee, M. Zhang, H. P. Kim, D. B. Stolz, S. W. Ryter, and A. M. K. Choi (2012) 46, 507-514
|Abstract »|Full Text »|PDF »
Nitric oxide-dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition.
Z. Chen, F. R. Bakhshi, A. N. Shajahan, T. Sharma, M. Mao, A. Trane, P. Bernatchez, G. P. van Nieuw Amerongen, M. G. Bonini, R. A. Skidgel, et al. (2012)
Mol. Biol. Cell
23, 1388-1398
|Abstract »|Full Text »|PDF »
Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1.
P. M. Bauer, E. M. Bauer, N. M. Rogers, M. Yao, M. Feijoo-Cuaresma, J. M. Pilewski, H. C. Champion, B. S. Zuckerbraun, M. J. Calzada, and J. S. Isenberg (2012)
Cardiovasc Res
93, 682-693
|Abstract »|Full Text »|PDF »
Caveolin targeting to late endosome/lysosomal membranes is induced by perturbations of lysosomal pH and cholesterol content.
D. I. Mundy, W. P. Li, K. Luby-Phelps, and R. G. W. Anderson (2012)
Mol. Biol. Cell
23, 864-880
|Abstract »|Full Text »|PDF »
Short-term weightlessness produced by parabolic flight maneuvers altered gene expression patterns in human endothelial cells.
J. Grosse, M. Wehland, J. Pietsch, X. Ma, C. Ulbrich, H. Schulz, K. Saar, N. Hubner, J. Hauslage, R. Hemmersbach, et al. (2012)
FASEB J
26, 639-655
|Abstract »|Full Text »|PDF »
Caveolin-1 is essential for metformin inhibitory effect on IGF1 action in non-small-cell lung cancer cells.
B. Salani, S. Maffioli, M. Hamoudane, A. Parodi, S. Ravera, M. Passalacqua, A. Alama, M. Nhiri, R. Cordera, and D. Maggi (2012)
FASEB J
26, 788-798
|Abstract »|Full Text »|PDF »
Endocytosis and Signaling: Cell Logistics Shape the Eukaryotic Cell Plan.
S. Sigismund, S. Confalonieri, A. Ciliberto, S. Polo, G. Scita, and P. P. Di Fiore (2012)
Physiol Rev
92, 273-366
|Abstract »|Full Text »|PDF »
Regulation of endothelial connexin40 expression by shear stress.
B. J. Vorderwulbecke, J. Maroski, K. Fiedorowicz, L. Da Silva-Azevedo, A. Marki, A. R. Pries, and A. Zakrzewicz (2012)
Am J Physiol Heart Circ Physiol
302, H143-H152
|Abstract »|Full Text »|PDF »
Caveolin-1 opens endothelial cell junctions by targeting catenins.
R. Kronstein, J. Seebach, S. Grossklaus, C. Minten, B. Engelhardt, M. Drab, S. Liebner, Y. Arsenijevic, A. A. Taha, T. Afanasieva, et al. (2012)
Cardiovasc Res
93, 130-140
|Abstract »|Full Text »|PDF »
Atrial natriuretic peptide enhances microvascular albumin permeability by the caveolae-mediated transcellular pathway.
W. Chen, B. Gassner, S. Borner, V. O. Nikolaev, N. Schlegel, J. Waschke, N. Steinbronn, R. Strasser, and M. Kuhn (2012)
Cardiovasc Res
93, 141-151
|Abstract »|Full Text »|PDF »
Role of caveolin-1 in endothelial BKCa channel regulation of vasoreactivity.
M. A. Riddle, J. M. Hughes, and B. R. Walker (2011)
Am J Physiol Cell Physiol
301, C1404-C1414
|Abstract »|Full Text »|PDF »
Caveolin-1 deficiency decreases atherosclerosis by hampering leukocyte influx into the arterial wall and generating a regulatory T-cell response.
D. Engel, L. Beckers, E. Wijnands, T. Seijkens, D. Lievens, M. Drechsler, N. Gerdes, O. Soehnlein, M. J. A. P. Daemen, R. V. Stan, et al. (2011)
FASEB J
25, 3838-3848
|Abstract »|Full Text »|PDF »
Caveolin-2 is a negative regulator of anti-proliferative function and signaling of transforming growth factor-{beta} in endothelial cells.
L. Xie, C. Vo-Ransdell, B. Abel, C. Willoughby, S. Jang, and G. Sowa (2011)
Am J Physiol Cell Physiol
301, C1161-C1174
|Abstract »|Full Text »|PDF »
Z. Li, H. Zhang, J. Liu, C.-P. Liang, Y. Li, Y. Li, G. Teitelman, T. Beyer, H. H. Bui, D. A. Peake, et al. (2011)
Mol. Cell. Biol.
31, 4205-4218
|Abstract »|Full Text »|PDF »
Altered Arachidonate Distribution in Macrophages from Caveolin-1 Null Mice Leading to Reduced Eicosanoid Synthesis.
A. M. Astudillo, G. Perez-Chacon, C. Meana, D. Balgoma, A. Pol, M. A. del Pozo, M. A. Balboa, and J. Balsinde (2011)
J. Biol. Chem.
286, 35299-35307
|Abstract »|Full Text »|PDF »
Shear stress increases endothelial hyaluronan synthase 2 and hyaluronan synthesis especially in regard to an atheroprotective flow profile.
J. Maroski, B. J. Vorderwulbecke, K. Fiedorowicz, L. Da Silva-Azevedo, G. Siegel, A. Marki, A. R. Pries, and A. Zakrzewicz (2011)
Exp Physiol
96, 977-986
|Abstract »|Full Text »|PDF »
Caveolin-1 Upregulation Mediates Suppression of Primary Breast Tumor Growth and Brain Metastases by Stat3 Inhibition.
W.-T. Chiu, H.-T. Lee, F.-J. Huang, K. D. Aldape, J. Yao, P. S. Steeg, C.-Y. Chou, Z. Lu, K. Xie, and S. Huang (2011)
Cancer Res.
71, 4932-4943
|Abstract »|Full Text »|PDF »
Elevated Inflammatory Response in Caveolin-1-deficient Mice with Pseudomonas aeruginosa Infection Is Mediated by STAT3 Protein and Nuclear Factor {kappa}B (NF-{kappa}B).
K. Yuan, C. Huang, J. Fox, M. Gaid, A. Weaver, G. Li, B. B. Singh, H. Gao, and M. Wu (2011)
J. Biol. Chem.
286, 21814-21825
|Abstract »|Full Text »|PDF »
Uterine Cysts in Female Mice Deficient for Caveolin-1 and Insulin-Like 3 Receptor RXFP2.
Z. Li, S. Feng, V. Lopez, G. Elhammady, M. L. Anderson, E. M. Kaftanovskaya, and A. I. Agoulnik (2011)
Endocrinology
152, 2474-2482
|Abstract »|Full Text »|PDF »
Caveolin-1 and force regulation in porcine airway smooth muscle.
V. Sathish, B. Yang, L. W. Meuchel, S. K. VanOosten, A. J. Ryu, M. A. Thompson, Y. S. Prakash, and C. M. Pabelick (2011)
Am J Physiol Lung Cell Mol Physiol
300, L920-L929
|Abstract »|Full Text »|PDF »
Role of Endosomes in Simian Virus 40 Entry and Infection.
S. Engel, T. Heger, R. Mancini, F. Herzog, J. Kartenbeck, A. Hayer, and A. Helenius (2011)
J. Virol.
85, 4198-4211
|Abstract »|Full Text »|PDF »
Involvement of Caveolin in Probucol-Induced Reduction in hERG Plasma-Membrane Expression.
J. Guo, X. Li, H. Shallow, J. Xu, T. Yang, H. Massaeli, W. Li, T. Sun, G. N. Pierce, and S. Zhang (2011)
Mol. Pharmacol.
79, 806-813
|Abstract »|Full Text »|PDF »
Inhibition of renal caveolin-1 reduces natriuresis and produces hypertension in sodium-loaded rats.
J. J. Gildea, B. A. Kemp, N. L. Howell, R. E. Van Sciver, R. M. Carey, and R. A. Felder (2011)
Am J Physiol Renal Physiol
300, F914-F920
|Abstract »|Full Text »|PDF »
Endogenous adipocyte apolipoprotein E is colocalized with caveolin at the adipocyte plasma membrane.
Autophagic Protein LC3B Confers Resistance against Hypoxia-induced Pulmonary Hypertension.
S.-J. Lee, A. Smith, L. Guo, T.-P. Alastalo, M. Li, H. Sawada, X. Liu, Z.-H. Chen, E. Ifedigbo, Y. Jin, et al. (2011) 183, 649-658
|Abstract »|Full Text »|PDF »
Polymerase I and Transcript Release Factor Regulates Lipolysis via a Phosphorylation-Dependent Mechanism.
N. Aboulaich, P. C. Chui, J. M. Asara, J. S. Flier, and E. Maratos-Flier (2011)
Diabetes
60, 757-765
|Abstract »|Full Text »|PDF »
Caveolin-1 Assembles Type 1 Inositol 1,4,5-Trisphosphate Receptors and Canonical Transient Receptor Potential 3 Channels into a Functional Signaling Complex in Arterial Smooth Muscle Cells.
A. Adebiyi, D. Narayanan, and J. H. Jaggar (2011)
J. Biol. Chem.
286, 4341-4348
|Abstract »|Full Text »|PDF »
Distinct Roles of Endothelial and Adipocyte Caveolin-1 in Macrophage Infiltration and Adipose Tissue Metabolic Activity.
N. Briand, S. Le Lay, W. C. Sessa, P. Ferre, and I. Dugail (2011)
Diabetes
60, 448-453
|Abstract »|Full Text »|PDF »
The effects of a high-fat, high-cholesterol diet on markers of uterine contractility during parturition in the rat.
M. J. Elmes, D. S.-Y. Tan, Z. Cheng, D. C. Wathes, and S. McMullen (2011)
Reproduction
141, 283-290
|Abstract »|Full Text »|PDF »
Caveolin-1: a critical regulator of lung injury.
Y. Jin, S.-J. Lee, R. D. Minshall, and A. M. K. Choi (2011)
Am J Physiol Lung Cell Mol Physiol
300, L151-L160
|Abstract »|Full Text »|PDF »
Caveolin-1 is required for vascular endothelial insulin uptake.
H. Wang, A. X. Wang, and E. J. Barrett (2011)
Am J Physiol Endocrinol Metab
300, E134-E144
|Abstract »|Full Text »|PDF »
Caveolin limits membrane microdomain mobility and integrin-mediated uptake of fibronectin-binding pathogens.
C. Hoffmann, A. Berking, F. Agerer, A. Buntru, F. Neske, G. S. Chhatwal, K. Ohlsen, and C. R. Hauck (2010)
J. Cell Sci.
123, 4280-4291
|Abstract »|Full Text »|PDF »
Caveolin-1 knockout mice exhibit impaired induction of mGluR-dependent long-term depression at CA3-CA1 synapses.
Y. Takayasu, K. Takeuchi, R. Kumari, M. V. L. Bennett, R. S. Zukin, and A. Francesconi (2010)
PNAS
107, 21778-21783
|Abstract »|Full Text »|PDF »
Caveolae at a glance.
M. Bastiani and R. G. Parton (2010)
J. Cell Sci.
123, 3831-3836
|Full Text »|PDF »
High-molecular-weight hyaluronan is a novel inhibitor of pulmonary vascular leakiness.
P. A. Singleton, T. Mirzapoiazova, Y. Guo, S. Sammani, N. Mambetsariev, F. E. Lennon, L. Moreno-Vinasco, and J. G. N. Garcia (2010)
Am J Physiol Lung Cell Mol Physiol
299, L639-L651
|Abstract »|Full Text »|PDF »
The Role of Proline in the Membrane Re-entrant Helix of Caveolin-1.
S. Aoki, A. Thomas, M. Decaffmeyer, R. Brasseur, and R. M. Epand (2010)
J. Biol. Chem.
285, 33371-33380
|Abstract »|Full Text »|PDF »
Quantitative Proteomics of Caveolin-1-regulated Proteins: CHARACTERIZATION OF POLYMERASE I AND TRANSCRIPT RELEASE FACTOR/CAVIN-1 IN ENDOTHELIAL CELLS.
A. Davalos, C. Fernandez-Hernando, G. Sowa, B. Derakhshan, M. I. Lin, J. Y. Lee, H. Zhao, R. Luo, C. Colangelo, and W. C. Sessa (2010)
Mol. Cell. Proteomics
9, 2109-2124
|Abstract »|Full Text »|PDF »
Caveolin-1-ablated mice survive in cold by nonshivering thermogenesis despite desensitized adrenergic responsiveness.
C. L. Mattsson, R. I. Csikasz, I. G. Shabalina, J. Nedergaard, and B. Cannon (2010)
Am J Physiol Endocrinol Metab
299, E374-E383
|Abstract »|Full Text »|PDF »
Caveolin-1 Protects against Sepsis by Modulating Inflammatory Response, Alleviating Bacterial Burden, and Suppressing Thymocyte Apoptosis.
H. Feng, L. Guo, Z. Song, H. Gao, D. Wang, W. Fu, J. Han, Z. Li, B. Huang, and X.-A. Li (2010)
J. Biol. Chem.
285, 25154-25160
|Abstract »|Full Text »|PDF »
Caveolin 1 Is Required for the Activation of Endothelial Nitric Oxide Synthase in Response to 17{beta}-Estradiol.
N. Sud, D. A. Wiseman, and S. M. Black (2010)
Mol. Endocrinol.
24, 1637-1649
|Abstract »|Full Text »|PDF »
Sensitivity of NOS-dependent vascular relaxation pathway to mineralocorticoid receptor blockade in caveolin-1-deficient mice.
L. H. Pojoga, Z. Adamova, A. Kumar, A. K. Stennett, J. R. Romero, G. K. Adler, G. H. Williams, and R. A. Khalil (2010)
Am J Physiol Heart Circ Physiol
298, H1776-H1788
|Abstract »|Full Text »|PDF »
Co-regulation of Caveolar and Cdc42-dependent Fluid Phase Endocytosis by Phosphocaveolin-1.
Z. J. Cheng, R. D. Singh, E. L. Holicky, C. L. Wheatley, D. L. Marks, and R. E. Pagano (2010)
J. Biol. Chem.
285, 15119-15125
|Abstract »|Full Text »|PDF »
Stromal regulation of vessel stability by MMP14 and TGF{beta}.
N. E. Sounni, K. Dehne, L. van Kempen, M. Egeblad, N. I. Affara, I. Cuevas, J. Wiesen, S. Junankar, L. Korets, J. Lee, et al. (2010)
Dis. Model. Mech.
3, 317-332
|Abstract »|Full Text »|PDF »
Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation.
Caveolin-1 Ablation Reduces the Adverse Cardiovascular Effects of N-{omega}-Nitro-L-Arginine Methyl Ester and Angiotensin II.
L. H. Pojoga, J. R. Romero, T. M. Yao, P. Loutraris, V. Ricchiuti, P. Coutinho, C. Guo, N. Lapointe, J. R. Stone, G. K. Adler, et al. (2010)
Endocrinology
151, 1236-1246
|Abstract »|Full Text »|PDF »
Endothelial cells isolated from caveolin-2 knockout mice display higher proliferation rate and cell cycle progression relative to their wild-type counterparts.
L. Xie, P. G. Frank, M. P. Lisanti, and G. Sowa (2010)
Am J Physiol Cell Physiol
298, C693-C701
|Abstract »|Full Text »|PDF »
Caveolin-1 Modifies the Immunity to Pseudomonas aeruginosa.
M. Gadjeva, C. Paradis-Bleau, G. P. Priebe, R. Fichorova, and G. B. Pier (2010)
J. Immunol.
184, 296-302
|Abstract »|Full Text »|PDF »
Caveolin-1 and Lipid Microdomains Regulate Gs Trafficking and Attenuate Gs/Adenylyl Cyclase Signaling.
J. A. Allen, J. Z. Yu, R. H. Dave, A. Bhatnagar, B. L. Roth, and M. M. Rasenick (2009)
Mol. Pharmacol.
76, 1082-1093
|Abstract »|Full Text »|PDF »
Contributions of quantitative proteomics to understanding membrane microdomains.
The Trafficking/Interaction of eNOS and Caveolin-1 Induced by Insulin Modulates Endothelial Nitric Oxide Production.
H. Wang, A. X. Wang, Z. Liu, W. Chai, and E. J. Barrett (2009)
Mol. Endocrinol.
23, 1613-1623
|Abstract »|Full Text »|PDF »
Phosphorylation of Caveolin-1 Regulates Oxidant-Induced Pulmonary Vascular Permeability via Paracellular and Transcellular Pathways.
Y. Sun, G. Hu, X. Zhang, and R. D. Minshall (2009)
Circ. Res.
105, 676-685
|Abstract »|Full Text »|PDF »
The Absence of Caveolin-1 Increases Proliferation and Anchorage- Independent Growth by a Rac-Dependent, Erk-Independent Mechanism.
A. Cerezo, M. C. Guadamillas, J. G. Goetz, S. Sanchez-Perales, E. Klein, R. K. Assoian, and M. A. del Pozo (2009)
Mol. Cell. Biol.
29, 5046-5059
|Abstract »|Full Text »|PDF »
Compartmentalizing VEGF-Induced ERK2/1 Signaling in Placental Artery Endothelial Cell Caveolae: A Paradoxical Role of Caveolin-1 in Placental Angiogenesis in Vitro.
W.-x. Liao, L. Feng, H. Zhang, J. Zheng, T. R. Moore, and D.-b. Chen (2009)
Mol. Endocrinol.
23, 1428-1444
|Abstract »|Full Text »|PDF »
Targeting and Imaging Signature Caveolar Molecules in Lungs.
Caveolin-1-dependent and -independent membrane domains.
S. Le Lay, Q. Li, N. Proschogo, M. Rodriguez, K. Gunaratnam, S. Cartland, C. Rentero, W. Jessup, T. Mitchell, and K. Gaus (2009)
J. Lipid Res.
50, 1609-1620
|Abstract »|Full Text »|PDF »
Caveolin-1 Loss of Function Accelerates Glucose Transporter 4 and Insulin Receptor Degradation in 3T3-L1 Adipocytes.
E. Gonzalez-Munoz, C. Lopez-Iglesias, M. Calvo, M. Palacin, A. Zorzano, and M. Camps (2009)
Endocrinology
150, 3493-3502
|Abstract »|Full Text »|PDF »
Cystic fibrosis transmembrane conductance regulator and caveolin-1 regulate epithelial cell internalization of Pseudomonas aeruginosa.
M. Bajmoczi, M. Gadjeva, S. L. Alper, G. B. Pier, and D. E. Golan (2009)
Am J Physiol Cell Physiol
297, C263-C277
|Abstract »|Full Text »|PDF »
Role of caveolin-1 in thyroid phenotype, cell homeostasis, and hormone synthesis: in vivo study of caveolin-1 knockout mice.
M. Senou, M. J. Costa, C. Massart, M. Thimmesch, C. Khalifa, S. Poncin, M. Boucquey, A.-C. Gerard, J.-N. Audinot, C. Dessy, et al. (2009)
Am J Physiol Endocrinol Metab
297, E438-E451
|Abstract »|Full Text »|PDF »
Unaltered size selectivity of the glomerular filtration barrier in caveolin-1 knockout mice.
G. Grande, C. Rippe, A. Rippe, A. Rahman, K. Sward, and B. Rippe (2009)
Am J Physiol Renal Physiol
297, F257-F262
|Abstract »|Full Text »|PDF »
Macrophage Sphingomyelin Synthase 2 Deficiency Decreases Atherosclerosis in Mice.
J. Liu, C. Huan, M. Chakraborty, H. Zhang, D. Lu, M.-S. Kuo, G. Cao, and X.-C. Jiang (2009)
Circ. Res.
105, 295-303
|Abstract »|Full Text »|PDF »
Vascular Caveolin Deficiency Supports the Angiogenic Effects of Nitrite, a Major End Product of Nitric Oxide Metabolism in Tumors.
F. Frerart, I. Lobysheva, B. Gallez, C. Dessy, and O. Feron (2009)
Mol. Cancer Res.
7, 1056-1063
|Abstract »|Full Text »|PDF »
MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes.
M. Bastiani, L. Liu, M. M. Hill, M. P. Jedrychowski, S. J. Nixon, H. P. Lo, D. Abankwa, R. Luetterforst, M. Fernandez-Rojo, M. R. Breen, et al. (2009)
J. Cell Biol.
185, 1259-1273
|Abstract »|Full Text »|PDF »
Molecular mechanisms of clathrin-independent endocytosis.
Monomeric C-reactive protein activates endothelial cells via interaction with lipid raft microdomains.
S.-R. Ji, L. Ma, C.-J. Bai, J.-M. Shi, H.-Y. Li, L. A. Potempa, J. G. Filep, J. Zhao, and Y. Wu (2009)
FASEB J
23, 1806-1816
|Abstract »|Full Text »|PDF »
Akt-Mediated Transactivation of the S1P1 Receptor in Caveolin-Enriched Microdomains Regulates Endothelial Barrier Enhancement by Oxidized Phospholipids.
P. A. Singleton, S. Chatchavalvanich, P. Fu, J. Xing, A. A. Birukova, J. A. Fortune, A. M. Klibanov, J. G. N. Garcia, and K. G. Birukov (2009)
Circ. Res.
104, 978-986
|Abstract »|Full Text »|PDF »
eNOS Activation by Physical Forces: From Short-Term Regulation of Contraction to Chronic Remodeling of Cardiovascular Tissues.
The Heme Oxygenase-1/Carbon Monoxide Pathway Suppresses TLR4 Signaling by Regulating the Interaction of TLR4 with Caveolin-1.
X. M. Wang, H. P. Kim, K. Nakahira, S. W. Ryter, and A. M. K. Choi (2009)
J. Immunol.
182, 3809-3818
|Abstract »|Full Text »|PDF »
Caveolin-2 Is Required for Apical Lipid Trafficking and Suppresses Basolateral Recycling Defects in the Intestine of Caenorhabditis elegans.
S. Parker, D. S. Walker, S. Ly, and H. A. Baylis (2009)
Mol. Biol. Cell
20, 1763-1771
|Abstract »|Full Text »|PDF »
Enhanced myogenic constriction of mesenteric artery in heart failure relates to decreased smooth muscle cell caveolae numbers and altered AT1- and epidermal growth factor-receptor function.
Y. Xu, R. H. Henning, M. Sandovici, J. J. van der Want, W. H. van Gilst, and H. Buikema (2009)
Eur J Heart Fail
11, 246-255
|Abstract »|Full Text »|PDF »
Dysfunctional Microvasculature as a Consequence of Shb Gene Inactivation Causes Impaired Tumor Growth.
N. S. Funa, V. Kriz, G. Zang, G. Calounova, B. Akerblom, J. Mares, E. Larsson, Y. Sun, C. Betsholtz, and M. Welsh (2009)
Cancer Res.
69, 2141-2148
|Abstract »|Full Text »|PDF »
Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity.
P. M. Haram, O. J. Kemi, S. J. Lee, M. O. Bendheim, Q. Y. Al-Share, H. L. Waldum, L. J. Gilligan, L. G. Koch, S. L. Britton, S. M. Najjar, et al. (2009)
Cardiovasc Res
81, 723-732
|Abstract »|Full Text »|PDF »
Cell Entry of Arginine-rich Peptides Is Independent of Endocytosis.
G. Ter-Avetisyan, G. Tunnemann, D. Nowak, M. Nitschke, A. Herrmann, M. Drab, and M. C. Cardoso (2009)
J. Biol. Chem.
284, 3370-3378
|Abstract »|Full Text »|PDF »
Guanosine Triphosphate Cyclohydrolase I Expression and Enzymatic Activity Are Present in Caveolae of Endothelial Cells.
T. E. Peterson, L. V. d'Uscio, S. Cao, X.-L. Wang, and Z. S. Katusic (2009)
Hypertension
53, 189-195
|Abstract »|Full Text »|PDF »
