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Science 293 (5539): 2453-2455

Copyright © 2001 by the American Association for the Advancement of Science

Correlation Between Histone Lysine Methylation and Developmental Changes at the Chicken beta -Globin Locus

Michael D. Litt,1 Melanie Simpson,1 Miklos Gaszner,1 C. David Allis,2 Gary Felsenfeld1*

Methylation of histones at specific residues plays an important role in transcriptional regulation. Chromatin immunoprecipitation of dimethylated lysine 9 on histone H3 across 53 kilobases of the chicken beta -globin locus during erythropoiesis shows an almost complete anticorrelation between regions of elevated lysine 9 methylation and acetylation. Lysine 9 is methylated most over constitutive condensed chromatin and developmentally inactive globin genes. In contrast, lysine 4 methylation of histone H3 correlates with H3 acetylation. These results lead us to propose a mechanism by which the insulator in the beta -globin locus can protect the globin genes from being silenced by adjacent condensed chromatin.

1 Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0540, USA.
2 Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA.
*   To whom correspondence should be addressed. E-mail: gxf{at}

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Mapping Development-Related and Age-Related Chromatin Remodeling by a High Throughput ChIP-HPLC Approach.
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J Gerontol A Biol Sci Med Sci 59, 1234-1243
   Abstract »    Full Text »    PDF »
Dynamic histone modifications mark sex chromosome inactivation and reactivation during mammalian spermatogenesis.
A. M. Khalil, F. Z. Boyar, and D. J. Driscoll (2004)
PNAS 101, 16583-16587
   Abstract »    Full Text »    PDF »
Promoter-restricted histone code, not the differentially methylated DNA regions or antisense transcripts, marks the imprinting status of IGF2R in human and mouse.
T. H. Vu, T. Li, and A. R. Hoffman (2004)
Hum. Mol. Genet. 13, 2233-2245
   Abstract »    Full Text »    PDF »
Highly specific interactions between bHLH transcription factors and chromatin during retina development.
D. Skowronska-Krawczyk, M. Ballivet, B. D. Dynlacht, and J.-M. Matter (2004)
Development 131, 4447-4454
   Abstract »    Full Text »    PDF »
A novel type of silencing factor, Clr2, is necessary for transcriptional silencing at various chromosomal locations in the fission yeast Schizosaccharomyces pombe.
P. Bjerling, K. Ekwall, R. Egel, and G. Thon (2004)
Nucleic Acids Res. 32, 4421-4428
   Abstract »    Full Text »    PDF »
A Histone Methyltransferase Is Required for Maximal Response to Female Sex Hormones.
T. Carling, K.-C. Kim, X.-H. Yang, J. Gu, X.-K. Zhang, and S. Huang (2004)
Mol. Cell. Biol. 24, 7032-7042
   Abstract »    Full Text »    PDF »
Identification of the Drosophila interband-specific protein Z4 as a DNA-binding zinc-finger protein determining chromosomal structure.
H. Eggert, A. Gortchakov, and H. Saumweber (2004)
J. Cell Sci. 117, 4253-4264
   Abstract »    Full Text »    PDF »
Mechanisms of HP1-mediated gene silencing in Drosophila.
J. R. Danzer and L. L. Wallrath (2004)
Development 131, 3571-3580
   Abstract »    Full Text »    PDF »
Accumulation of Heterochromatin Components on the Terminal Repeat Sequence of Kaposi's Sarcoma-Associated Herpesvirus Mediated by the Latency-Associated Nuclear Antigen.
S. Sakakibara, K. Ueda, K. Nishimura, E. Do, E. Ohsaki, T. Okuno, and K. Yamanishi (2004)
J. Virol. 78, 7299-7310
   Abstract »    Full Text »    PDF »

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