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Science 294 (5542): 564-567

Copyright © 2001 by the American Association for the Advancement of Science

Induction of Pancreatic Differentiation by Signals from Blood Vessels

Eckhard Lammert,* Ondine Cleaver,* Douglas Meltondagger

Blood vessels supply developing organs with metabolic sustenance. Here, we demonstrate a role for blood vessels as a source of developmental signals during pancreatic organogenesis. In vitro experiments with embryonic mouse tissues demonstrate that blood vessel endothelium induces insulin expression in isolated endoderm. Removal of the dorsal aorta in Xenopus laevis embryos results in the failure of insulin expression in vivo. Furthermore, using transgenic mice, we show that ectopic vascularization in the posterior foregut leads to ectopic insulin expression and islet hyperplasia. These results indicate that vessels not only provide metabolic sustenance, but also provide inductive signals for organ development.

Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed.

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Arachidonic Acid Predominates in the Membrane Phosphoglycerides of the Early and Term Human Placenta.
D. Bitsanis, M. A. Crawford, T. Moodley, H. Holmsen, K. Ghebremeskel, and O. Djahanbakhch (2005)
J. Nutr. 135, 2566-2571
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Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development.
M. J. Hilton, X. Tu, J. Cook, H. Hu, and F. Long (2005)
Development 132, 4339-4351
   Abstract »    Full Text »    PDF »
Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme.
J. Edsbagge, J. K. Johansson, F. Esni, Y. Luo, G. L. Radice, and H. Semb (2005)
Development 132, 1085-1092
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Role of oxygen and vascular development in epithelial branching morphogenesis of the developing mouse lung.
M. van Tuyl, J. Liu, J. Wang, M. Kuliszewski, D. Tibboel, and M. Post (2005)
Am J Physiol Lung Cell Mol Physiol 288, L167-L178
   Abstract »    Full Text »    PDF »
Down-regulation of Plasminogen Activator Inhibitor 1 Expression Promotes Myocardial Neovascularization by Bone Marrow Progenitors.
G. Xiang, M. D. Schuster, T. Seki, A. A. Kocher, S. Eshghi, A. Boyle, and S. Itescu (2004)
J. Exp. Med. 200, 1657-1666
   Abstract »    Full Text »    PDF »

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