Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 294 (5542): 605-609

Copyright © 2001 by the American Association for the Advancement of Science

Regulation of Cutaneous Malignancy by gamma &dgr; T Cells

Michael Girardi,1* David E. Oppenheim,2* Carrie R. Steele,2 Julia M. Lewis,1 Earl Glusac,1 Renata Filler,1 Paul Hobby,3 Brian Sutton,3 Robert E. Tigelaar,1 Adrian C. Hayday2dagger

The localization of gamma delta T cells within epithelia suggests that these cells may contribute to the down-regulation of epithelial malignancies. We report that mice lacking gamma delta cells are highly susceptible to multiple regimens of cutaneous carcinogenesis. After exposure to carcinogens, skin cells expressed Rae-1 and H60, major histocompatibility complex-related molecules structurally resembling human MICA. Each of these is a ligand for NKG2d, a receptor expressed by cytolytic T cells and natural killer (NK) cells. In vitro, skin-associated NKG2d+ gamma delta cells killed skin carcinoma cells by a mechanism that was sensitive to blocking NKG2d engagement. Thus, local T cells may use evolutionarily conserved proteins to negatively regulate malignancy.

1 Department of Dermatology and Yale Skin Diseases Research Core Center,
2 Peter Gorer Department of Immunobiology, Guy's King's St. Thomas' Medical School,
3 Randall Centre for Molecular Medicine, Guy's Hospital, King's College, London SE1 9RT, UK.
*   These authors contributed equally to this report.

dagger    To whom correspondence should be addressed. E-mail: adrian.hayday{at}

Human {gamma}{delta} Thymocytes Are Functionally Immature and Differentiate into Cytotoxic Type 1 Effector T Cells upon IL-2/IL-15 Signaling.
J. C. Ribot, S. T. Ribeiro, D. V. Correia, A. E. Sousa, and B. Silva-Santos (2014)
J. Immunol. 192, 2237-2243
   Abstract »    Full Text »    PDF »
Targeted deletion of RasGRP1 impairs skin tumorigenesis.
A. Sharma, L. L. Fonseca, C. Rajani, J. K. Yanagida, Y. Endo, J. M. Cline, J. C. Stone, J. Ji, J. W. Ramos, and P. S. Lorenzo (2014)
   Abstract »    Full Text »    PDF »
"Designed" grafts for HLA-haploidentical stem cell transplantation.
M. F. Martelli, M. Di Ianni, L. Ruggeri, A. Pierini, F. Falzetti, A. Carotti, A. Terenzi, Y. Reisner, F. Aversa, B. Falini, et al. (2014)
Blood 123, 967-973
   Abstract »    Full Text »    PDF »
Aminobisphosphonates prevent the inhibitory effects exerted by lymph node stromal cells on anti-tumor V{delta} 2 T lymphocytes in non-Hodgkin lymphomas.
A. Musso, S. Catellani, P. Canevali, S. Tavella, R. Vene, S. Boero, I. Pierri, M. Gobbi, A. Kunkl, J.-L. Ravetti, et al. (2014)
Haematologica 99, 131-139
   Abstract »    Full Text »    PDF »
At the Bench: Preclinical rationale for exploiting NK cells and {gamma}{delta} T lymphocytes for the treatment of high-risk leukemias.
H. Norell, A. Moretta, B. Silva-Santos, and L. Moretta (2013)
J. Leukoc. Biol. 94, 1123-1139
   Abstract »    Full Text »    PDF »
At the Bedside: Innate immunity as an immunotherapy tool for hematological malignancies.
F. Locatelli, P. Merli, and S. Rutella (2013)
J. Leukoc. Biol. 94, 1141-1157
   Abstract »    Full Text »    PDF »
The Invisible Arm of Immunity in Common Cancer Chemoprevention Agents.
E. Marzbani, C. Inatsuka, H. Lu, and M. L. Disis (2013)
Cancer Prevention Research 6, 764-773
   Abstract »    Full Text »    PDF »
Cross-talk between intraepithelial {gamma}{delta} T cells and epithelial cells.
D. A. Witherden and W. L. Havran (2013)
J. Leukoc. Biol. 94, 69-76
   Abstract »    Full Text »    PDF »
Protective Role of the Inflammatory CCR2/CCL2 Chemokine Pathway through Recruitment of Type 1 Cytotoxic {gamma}{delta} T Lymphocytes to Tumor Beds.
T. Lanca, M. F. Costa, N. Goncalves-Sousa, M. Rei, A. R. Grosso, C. Penido, and B. Silva-Santos (2013)
J. Immunol. 190, 6673-6680
   Abstract »    Full Text »    PDF »
Programmed Downregulation of CCR6 Is Important for Establishment of Epidermal {gamma}{delta}T Cells by Regulating Their Thymic Egress and Epidermal Location.
S. Hu and N. Xiong (2013)
J. Immunol. 190, 3267-3275
   Abstract »    Full Text »    PDF »
RAE-1 ligands for the NKG2D receptor are regulated by E2F transcription factors, which control cell cycle entry.
H. Jung, B. Hsiung, K. Pestal, E. Procyk, and D. H. Raulet (2012)
J. Exp. Med. 209, 2409-2422
   Abstract »    Full Text »    PDF »
Involvement of an NKG2D Ligand H60c in Epidermal Dendritic T Cell-Mediated Wound Repair.
S. Yoshida, R. H. Mohamed, M. Kajikawa, J. Koizumi, M. Tanaka, K. Fugo, N. Otsuka, K. Maenaka, H. Yagita, H. Chiba, et al. (2012)
J. Immunol. 188, 3972-3979
   Abstract »    Full Text »    PDF »
High ERp5/ADAM10 expression in lymph node microenvironment and impaired NKG2D ligands recognition in Hodgkin lymphomas.
M. R. Zocchi, S. Catellani, P. Canevali, S. Tavella, A. Garuti, B. Villaggio, A. Zunino, M. Gobbi, G. Fraternali-Orcioni, A. Kunkl, et al. (2012)
Blood 119, 1479-1489
   Abstract »    Full Text »    PDF »
Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma.
B. G. Modi, J. Neustadter, E. Binda, J. Lewis, R. B. Filler, S. J. Roberts, B. Y. Kwong, S. Reddy, J. D. Overton, A. Galan, et al. (2012)
Science 335, 104-108
   Abstract »    Full Text »    PDF »
The Intraepithelial T Cell Response to NKG2D-Ligands Links Lymphoid Stress Surveillance to Atopy.
J. Strid, O. Sobolev, B. Zafirova, B. Polic, and A. Hayday (2011)
Science 334, 1293-1297
   Abstract »    Full Text »    PDF »
IL-17/IFN-{gamma} double producing CD8+ T (Tc17/IFN-{gamma}) cells: A novel cytotoxic T-cell subset converted from Tc17 cells by IL-12.
M. Tajima, D. Wakita, T. Satoh, H. Kitamura, and T. Nishimura (2011)
Int. Immunol. 23, 751-759
   Abstract »    Full Text »    PDF »
Regulatory Role of V{gamma}1 {gamma}{delta} T Cells in Tumor Immunity through IL-4 Production.
J. Hao, S. Dong, S. Xia, W. He, H. Jia, S. Zhang, J. Wei, R. L. O'Brien, W. K. Born, Z. Wu, et al. (2011)
J. Immunol. 187, 4979-4986
   Abstract »    Full Text »    PDF »
Cancer Immunoediting of the NK Group 2D Ligand H60a.
T. O'Sullivan, G. P. Dunn, D. Y. Lacoursiere, R. D. Schreiber, and J. D. Bui (2011)
J. Immunol. 187, 3538-3545
   Abstract »    Full Text »    PDF »
Aryl Hydrocarbon Receptor Is Critical for Homeostasis of Invariant {gamma}{delta} T Cells in the Murine Epidermis.
S. Kadow, B. Jux, S. P. Zahner, B. Wingerath, S. Chmill, B. E. Clausen, J. Hengstler, and C. Esser (2011)
J. Immunol. 187, 3104-3110
   Abstract »    Full Text »    PDF »
Identification of a Novel Proinflammatory Human Skin-Homing V{gamma}9V{delta}2 T Cell Subset with a Potential Role in Psoriasis.
U. Laggner, P. Di Meglio, G. K. Perera, C. Hundhausen, K. E. Lacy, N. Ali, C. H. Smith, A. C. Hayday, B. J. Nickoloff, and F. O. Nestle (2011)
J. Immunol. 187, 2783-2793
   Abstract »    Full Text »    PDF »
Differentiation of human peripheral blood V{delta}1+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells.
D. V. Correia, M. Fogli, K. Hudspeth, M. G. da Silva, D. Mavilio, and B. Silva-Santos (2011)
Blood 118, 992-1001
   Abstract »    Full Text »    PDF »
Langerhans cells are not required for epidermal V{gamma}3 T cell homeostasis and function.
S. Taveirne, V. De Colvenaer, T. Van Den Broeck, E. Van Ammel, C. L. Bennett, T. Taghon, B. Vandekerckhove, J. Plum, B. E. Clausen, D. H. Kaplan, et al. (2011)
J. Leukoc. Biol. 90, 61-68
   Abstract »    Full Text »    PDF »
Role for E-Cadherin as an Inhibitory Receptor on Epidermal {gamma}{delta} T Cells.
Y. Uchida, K. Kawai, A. Ibusuki, and T. Kanekura (2011)
J. Immunol. 186, 6945-6954
   Abstract »    Full Text »    PDF »
Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion.
R. D. Schreiber, L. J. Old, and M. J. Smyth (2011)
Science 331, 1565-1570
   Abstract »    Full Text »    PDF »
Cutaneous immunosurveillance by self-renewing dermal {gamma}{delta} T cells.
N. Sumaria, B. Roediger, L. G. Ng, J. Qin, R. Pinto, L. L. Cavanagh, E. Shklovskaya, B. Fazekas de St. Groth, J. A. Triccas, and W. Weninger (2011)
J. Exp. Med. 208, 505-518
   Abstract »    Full Text »    PDF »
Skint-1 is a highly specific, unique selecting component for epidermal T cells.
S. D. Barbee, M. J. Woodward, G. Turchinovich, J.-J. Mention, J. M. Lewis, L. M. Boyden, R. P. Lifton, R. Tigelaar, and A. C. Hayday (2011)
PNAS 108, 3330-3335
   Abstract »    Full Text »    PDF »
Role of immune-regulatory cells in skin pathology.
D. Ilkovitch (2011)
J. Leukoc. Biol. 89, 41-49
   Abstract »    Full Text »    PDF »
Expression of Snail in Epidermal Keratinocytes Promotes Cutaneous Inflammation and Hyperplasia Conducive to Tumor Formation.
F. Du, Y. Nakamura, T.-L. Tan, P. Lee, R. Lee, B. Yu, and C. Jamora (2010)
Cancer Res. 70, 10080-10089
   Abstract »    Full Text »    PDF »
CCR10 Is Important for the Development of Skin-Specific {gamma}{delta}T Cells by Regulating Their Migration and Location.
Y. Jin, M. Xia, A. Sun, C. M. Saylor, and N. Xiong (2010)
J. Immunol. 185, 5723-5731
   Abstract »    Full Text »    PDF »
T-bet and Eomesodermin Are Required for T Cell-Mediated Antitumor Immune Responses.
Y. Zhu, S. Ju, E. Chen, S. Dai, C. Li, P. Morel, L. Liu, X. Zhang, and B. Lu (2010)
J. Immunol. 185, 3174-3183
   Abstract »    Full Text »    PDF »
The Junctional Adhesion Molecule JAML Is a Costimulatory Receptor for Epithelial {gamma}{delta} T Cell Activation.
D. A. Witherden, P. Verdino, S. E. Rieder, O. Garijo, R. E. Mills, L. Teyton, W. H. Fischer, I. A. Wilson, and W. L. Havran (2010)
Science 329, 1205-1210
   Abstract »    Full Text »    PDF »
Identification of a panel of ten cell surface protein antigens associated with immunotargeting of leukemias and lymphomas by peripheral blood {gamma}{delta} T cells.
A. Q. Gomes, D. V. Correia, A. R. Grosso, T. Lanca, C. Ferreira, J. F. Lacerda, J. T. Barata, M. G. d. Silva, and B. Silva-Santos (2010)
Haematologica 95, 1397-1404
   Abstract »    Full Text »    PDF »
Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r{gamma}null humanized mice.
L. D. Shultz, Y. Saito, Y. Najima, S. Tanaka, T. Ochi, M. Tomizawa, T. Doi, A. Sone, N. Suzuki, H. Fujiwara, et al. (2010)
PNAS 107, 13022-13027
   Abstract »    Full Text »    PDF »
Naturally Activated V{gamma}4 {gamma}{delta} T Cells Play a Protective Role in Tumor Immunity through Expression of Eomesodermin.
W. He, J. Hao, S. Dong, Y. Gao, J. Tao, H. Chi, R. Flavell, R. L. O'Brien, W. K. Born, J. Craft, et al. (2010)
J. Immunol. 185, 126-133
   Abstract »    Full Text »    PDF »
IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis.
M. W. L. Teng, D. M. Andrews, N. McLaughlin, B. von Scheidt, S. F. Ngiow, A. Moller, G. R. Hill, Y. Iwakura, M. Oft, and M. J. Smyth (2010)
PNAS 107, 8328-8333
   Abstract »    Full Text »    PDF »
Epidermal {gamma}{delta} T cells sense precancerous cellular dysregulation and initiate immune responses.
E. Shimura, N. Hozumi, O. Kanagawa, D. Metzger, P. Chambon, F. Radtke, S. Hirose, and N. Nakano (2010)
Int. Immunol. 22, 329-340
   Abstract »    Full Text »    PDF »
The MHC class Ib protein ULBP1 is a nonredundant determinant of leukemia/lymphoma susceptibility to {gamma}{delta} T-cell cytotoxicity.
T. Lanca, D. V. Correia, C. F. Moita, H. Raquel, A. Neves-Costa, C. Ferreira, J. S. Ramalho, J. T. Barata, L. F. Moita, A. Q. Gomes, et al. (2010)
Blood 115, 2407-2411
   Abstract »    Full Text »    PDF »
Development of Promyelocytic Zinc Finger and ThPOK-Expressing Innate {gamma}{delta} T Cells Is Controlled by Strength of TCR Signaling and Id3.
E. S. Alonzo, R. A. Gottschalk, J. Das, T. Egawa, R. M. Hobbs, P. P. Pandolfi, P. Pereira, K. E. Nichols, G. A. Koretzky, M. S. Jordan, et al. (2010)
J. Immunol. 184, 1268-1279
   Abstract »    Full Text »    PDF »
Protection from Cancer in Kidney Transplant Patients by {gamma}{delta} T Cells: Role of CMV Infection?.
C. Soderberg-Naucler (2010)
J. Am. Soc. Nephrol. 21, 11-13
   Full Text »    PDF »
Cytomegalovirus-Induced {gamma}{delta} T Cells Associate with Reduced Cancer Risk after Kidney Transplantation.
L. Couzi, Y. Levaillant, A. Jamai, V. Pitard, R. Lassalle, K. Martin, I. Garrigue, O. Hawchar, F. Siberchicot, N. Moore, et al. (2010)
J. Am. Soc. Nephrol. 21, 181-188
   Abstract »    Full Text »    PDF »
Prevention of Mammary Carcinogenesis in MMTV-neu Mice by Cruciferous Vegetable Constituent Benzyl Isothiocyanate.
R. Warin, W. H. Chambers, D. M. Potter, and S. V. Singh (2009)
Cancer Res. 69, 9473-9480
   Abstract »    Full Text »    PDF »
Recombination Signal Sequence-Associated Restriction on TCR{delta} Gene Rearrangement Affects the Development of Tissue-Specific {gamma}{delta} T Cells.
U. N. Uche, C. R. Huber, D. H. Raulet, and N. Xiong (2009)
J. Immunol. 183, 4931-4939
   Abstract »    Full Text »    PDF »
Dual role for Id2 in chemical carcinogen-induced skin tumorigenesis.
A. Tokuriki, T. Iyoda, K. Inaba, K. Ikuta, S. Fujimoto, M. Kumakiri, and Y. Yokota (2009)
Carcinogenesis 30, 1645-1650
   Abstract »    Full Text »    PDF »
Differential Susceptibility of RAE-1 Isoforms to Mouse Cytomegalovirus.
J. Arapovic, T. Lenac, R. Antulov, B. Polic, Z. Ruzsics, L. N. Carayannopoulos, U. H. Koszinowski, A. Krmpotic, and S. Jonjic (2009)
J. Virol. 83, 8198-8207
   Abstract »    Full Text »    PDF »
Characterization and immunotherapeutic potential of {gamma}{delta} T-cells in patients with glioblastoma.
N. L. Bryant, C. Suarez-Cuervo, G. Y. Gillespie, J. M. Markert, L. B. Nabors, S. Meleth, R. D. Lopez, and L. S. Lamb Jr. (2009)
Neuro Oncology 11, 357-367
   Abstract »    Full Text »    PDF »
IFN-{gamma}-dependent type 1 immunity is crucial for immunosurveillance against squamous cell carcinoma in a novel mouse carcinogenesis model.
D. Wakita, K. Chamoto, T. Ohkuri, Y. Narita, S. Ashino, K. Sumida, H. Nishikawa, H. Shiku, Y. Togashi, H. Kitamura, et al. (2009)
Carcinogenesis 30, 1408-1415
   Abstract »    Full Text »    PDF »
Antitumor Activity of {gamma}{delta} T Cells Reactive against Cytomegalovirus-Infected Cells in a Mouse Xenograft Tumor Model.
C. Devaud, E. Bilhere, S. Loizon, V. Pitard, C. Behr, J.-F. Moreau, J. Dechanet-Merville, and M. Capone (2009)
Cancer Res. 69, 3971-3978
   Abstract »    Full Text »    PDF »
Costimulation of Dendritic Epidermal {gamma}{delta} T Cells by a New NKG2D Ligand Expressed Specifically in the Skin.
M. I. Whang, N. Guerra, and D. H. Raulet (2009)
J. Immunol. 182, 4557-4564
   Abstract »    Full Text »    PDF »
A role for human skin-resident T cells in wound healing.
A. Toulon, L. Breton, K. R. Taylor, M. Tenenhaus, D. Bhavsar, C. Lanigan, R. Rudolph, J. Jameson, and W. L. Havran (2009)
J. Exp. Med. 206, 743-750
   Abstract »    Full Text »    PDF »
Accelerated tumor growth in mice deficient in DNAM-1 receptor.
A. Iguchi-Manaka, H. Kai, Y. Yamashita, K. Shibata, S. Tahara-Hanaoka, S.-i. Honda, T. Yasui, H. Kikutani, K. Shibuya, and A. Shibuya (2008)
J. Exp. Med. 205, 2959-2964
   Abstract »    Full Text »    PDF »
DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors.
S. Gilfillan, C. J. Chan, M. Cella, N. M. Haynes, A. S. Rapaport, K. S. Boles, D. M. Andrews, M. J. Smyth, and M. Colonna (2008)
J. Exp. Med. 205, 2965-2973
   Abstract »    Full Text »    PDF »
NK cells contribute to the skin graft rejection promoted by CD4+ T cells activated through the indirect allorecognition pathway.
A. Ito, H. Shimura, A. Nitahara, K. Tomiyama, M. Ito, T. Kanekura, K. Okumura, H. Yagita, and K. Kawai (2008)
Int. Immunol. 20, 1343-1349
   Abstract »    Full Text »    PDF »
Defects in Skin {gamma}{delta} T Cell Function Contribute to Delayed Wound Repair in Rapamycin-Treated Mice.
R. E. Mills, K. R. Taylor, K. Podshivalova, D. B. McKay, and J. M. Jameson (2008)
J. Immunol. 181, 3974-3983
   Abstract »    Full Text »    PDF »
An innate immune response of blood cells to tumors and tissue damage in Drosophila.
J. C. Pastor-Pareja, M. Wu, and T. Xu (2008)
Dis. Model. Mech. 1, 144-154
   Abstract »    Full Text »    PDF »
SCART Scavenger Receptors Identify a Novel Subset of Adult {gamma}{delta} T Cells.
J. Kisielow, M. Kopf, and K. Karjalainen (2008)
J. Immunol. 181, 1710-1716
   Abstract »    Full Text »    PDF »
Integrin {alpha}E(CD103){beta}7 influences cellular shape and motility in a ligand-dependent fashion.
S. Schlickum, H. Sennefelder, M. Friedrich, G. Harms, M. J. Lohse, P. Kilshaw, and M. P. Schon (2008)
Blood 112, 619-625
   Abstract »    Full Text »    PDF »
Antagonistic Roles of CD4+ and CD8+ T-Cells in 7,12-Dimethylbenz(a)anthracene Cutaneous Carcinogenesis.
N. Yusuf, T. H. Nasti, S. K. Katiyar, M. K. Jacobs, M. D. Seibert, A. C. Ginsburg, L. Timares, H. Xu, and C. A. Elmets (2008)
Cancer Res. 68, 3924-3930
   Abstract »    Full Text »    PDF »
Protective Immunosurveillance and Therapeutic Antitumor Activity of {gamma}{delta} T Cells Demonstrated in a Mouse Model of Prostate Cancer.
Z. Liu, I.-E. A. Eltoum, B. Guo, B. H. Beck, G. A. Cloud, and R. D. Lopez (2008)
J. Immunol. 180, 6044-6053
   Abstract »    Full Text »    PDF »
Gene placement and competition control T cell receptor {gamma} variable region gene rearrangement.
N. Xiong, L. Zhang, C. Kang, and D. H. Raulet (2008)
J. Exp. Med. 205, 929-938
   Abstract »    Full Text »    PDF »
Selective Induction of Expression of a Ligand for the NKG2D Receptor by Proteasome Inhibitors.
M. Vales-Gomez, S. E. Chisholm, R. L. Cassady-Cain, P. Roda-Navarro, and H. T. Reyburn (2008)
Cancer Res. 68, 1546-1554
   Abstract »    Full Text »    PDF »
Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance.
A. M. Unni, T. Bondar, and R. Medzhitov (2008)
PNAS 105, 1686-1691
   Abstract »    Full Text »    PDF »
Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis.
J. B. Swann, M. D. Vesely, A. Silva, J. Sharkey, S. Akira, R. D. Schreiber, and M. J. Smyth (2008)
PNAS 105, 652-656
   Abstract »    Full Text »    PDF »
Context-dependent regulation of cutaneous immunological responses by TGF{beta}1 and its role in skin carcinogenesis.
A. B. Glick, R. Perez-Lorenzo, and J. Mohammed (2008)
Carcinogenesis 29, 9-14
   Abstract »    Full Text »    PDF »
Non-classical major histocompatibility complex proteins as determinants of tumour immunosurveillance.
A. Q. Gomes, D. V. Correia, and B. Silva-Santos (2007)
EMBO Rep. 8, 1024-1030
   Abstract »    Full Text »    PDF »
DAP10 Deficiency Breaks the Immune Tolerance against Transplantable Syngeneic Melanoma.
N. Hyka-Nouspikel, L. Lucian, E. Murphy, T. McClanahan, and J. H. Phillips (2007)
J. Immunol. 179, 3763-3771
   Abstract »    Full Text »    PDF »
Cutaneous Two-Stage Chemical Carcinogenesis.
R. B. Filler, S. J. Roberts, and M. Girardi (2007)
Cold Spring Harb Protoc 2007, pdb.prot4837
   Abstract »    Full Text »
Targeting Human {gamma}{delta} T Cells with Zoledronate and Interleukin-2 for Immunotherapy of Hormone-Refractory Prostate Cancer.
F. Dieli, D. Vermijlen, F. Fulfaro, N. Caccamo, S. Meraviglia, G. Cicero, A. Roberts, S. Buccheri, M. D'Asaro, N. Gebbia, et al. (2007)
Cancer Res. 67, 7450-7457
   Abstract »    Full Text »    PDF »
Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors.
P. K. Epling-Burnette, F. Bai, J. S. Painter, D. E. Rollison, H. R. Salih, M. Krusch, J. Zou, E. Ku, B. Zhong, D. Boulware, et al. (2007)
Blood 109, 4816-4824
   Abstract »    Full Text »    PDF »
Characterizing tumor-promoting T cells in chemically induced cutaneous carcinogenesis.
S. J. Roberts, B. Y. Ng, R. B. Filler, J. Lewis, E. J. Glusac, A. C. Hayday, R. E. Tigelaar, and M. Girardi (2007)
PNAS 104, 6770-6775
   Abstract »    Full Text »    PDF »
Massive, sustained {gamma}{delta} T cell migration from the bovine skin in vivo.
I. Van Rhijn, V. P. M. G. Rutten, B. Charleston, M. Smits, W. van Eden, and A. P. Koets (2007)
J. Leukoc. Biol. 81, 968-973
   Abstract »    Full Text »    PDF »
Depletion of {gamma}{delta} T Cells Exacerbates Murine Adriamycin Nephropathy.
H. Wu, Y. M. Wang, Y. Wang, M. Hu, G. Y. Zhang, J. F. Knight, D. C.H. Harris, and S. I. Alexander (2007)
J. Am. Soc. Nephrol. 18, 1180-1189
   Abstract »    Full Text »    PDF »
The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development.
R. Grose, V. Fantl, S. Werner, A.-M. Chioni, M. Jarosz, R. Rudling, B. Cross, I. R. Hart, and C. Dickson (2007)
EMBO J. 26, 1268-1278
   Abstract »    Full Text »    PDF »
Expansion of V{delta}1 T lymphocytes producing IL-4 in low-grade non-Hodgkin lymphomas expressing UL-16-binding proteins.
S. Catellani, A. Poggi, A. Bruzzone, P. Dadati, J. L. Ravetti, M. Gobbi, and M. R. Zocchi (2007)
Blood 109, 2078-2085
   Abstract »    Full Text »    PDF »
Perspectives of {gamma}{delta} T Cells in Tumor Immunology.
D. Kabelitz, D. Wesch, and W. He (2007)
Cancer Res. 67, 5-8
   Abstract »    Full Text »    PDF »
Complex Interplay of Activating and Inhibitory Signals Received by V{gamma}9V{delta}2 T Cells Revealed by Target Cell {beta}2-Microglobulin Knockdown.
V. Trichet, C. Benezech, C. Dousset, M.-C. Gesnel, M. Bonneville, and R. Breathnach (2006)
J. Immunol. 177, 6129-6136
   Abstract »    Full Text »    PDF »
Coordination between CCR7- and CCR9-mediated chemokine signals in prevascular fetal thymus colonization.
C. Liu, F. Saito, Z. Liu, Y. Lei, S. Uehara, P. Love, M. Lipp, S. Kondo, N. Manley, and Y. Takahama (2006)
Blood 108, 2531-2539
   Abstract »    Full Text »    PDF »
Transcriptional Regulation of ULBP1, a Human Ligand of the NKG2D Receptor.
A. Lopez-Soto, A. Quinones-Lombrana, R. Lopez-Arbesu, C. Lopez-Larrea, and S. Gonzalez (2006)
J. Biol. Chem. 281, 30419-30430
   Abstract »    Full Text »    PDF »
ULBPs, human ligands of the NKG2D receptor, stimulate tumor immunity with enhancement by IL-15.
C. L. Sutherland, B. Rabinovich, N. J. Chalupny, P. Brawand, R. Miller, and D. Cosman (2006)
Blood 108, 1313-1319
   Abstract »    Full Text »    PDF »
NKG2D ligands are expressed on stressed human airway epithelial cells.
M. T. Borchers, N. L. Harris, S. C. Wesselkamper, M. Vitucci, and D. Cosman (2006)
Am J Physiol Lung Cell Mol Physiol 291, L222-L231
   Abstract »    Full Text »    PDF »
Comparative Analysis of Regulatory and Effector T Cells in Progressively Growing versus Rejecting Tumors of Similar Origins..
J. D. Bui, R. Uppaluri, C.-S. Hsieh, and R. D. Schreiber (2006)
Cancer Res. 66, 7301-7309
   Abstract »    Full Text »    PDF »
The NKG2D-Activating Receptor Mediates Pulmonary Clearance of Pseudomonas aeruginosa.
M. T. Borchers, N. L. Harris, S. C. Wesselkamper, S. Zhang, Y. Chen, L. Young, and G. W. Lau (2006)
Infect. Immun. 74, 2578-2586
   Abstract »    Full Text »    PDF »
Conditioning of langerhans cells induced by a primary CD8 T cell response to self-antigen in vivo..
D. Mayerova, L. Wang, L. S. Bursch, and K. A. Hogquist (2006)
J. Immunol. 176, 4658-4665
   Abstract »    Full Text »    PDF »
Homing and Function of Human Skin {gamma}{delta} T Cells and NK Cells: Relevance for Tumor Surveillance.
L. M. Ebert, S. Meuter, and B. Moser (2006)
J. Immunol. 176, 4331-4336
   Abstract »    Full Text »    PDF »
Placenta-Derived Soluble MHC Class I Chain-Related Molecules Down-Regulate NKG2D Receptor on Peripheral Blood Mononuclear Cells during Human Pregnancy: A Possible Novel Immune Escape Mechanism for Fetal Survival.
L. Mincheva-Nilsson, O. Nagaeva, T. Chen, U. Stendahl, J. Antsiferova, I. Mogren, J. Hernestal, and V. Baranov (2006)
J. Immunol. 176, 3585-3592
   Abstract »    Full Text »    PDF »
Proteolytic Release of Soluble UL16-Binding Protein 2 from Tumor Cells..
I. Waldhauer and A. Steinle (2006)
Cancer Res. 66, 2520-2526
   Abstract »    Full Text »    PDF »
IFN-Dependent Down-Regulation of the NKG2D Ligand H60 on Tumors.
J. D. Bui, L. N. Carayannopoulos, L. L. Lanier, W. M. Yokoyama, and R. D. Schreiber (2006)
J. Immunol. 176, 905-913
   Abstract »    Full Text »    PDF »
DNA Damage and Tumor Surveillance: One Trigger for Two Pathways.
P. Hoglund (2006)
Sci. STKE 2006, pe2
   Abstract »    Full Text »    PDF »
Cutting Edge: The AP-1 Subunit JunB Determines NK Cell-Mediated Target Cell Killing by Regulation of the NKG2D-Ligand RAE-1{epsilon}.
N. Nausch, L. Florin, B. Hartenstein, P. Angel, M. Schorpp-Kistner, and A. Cerwenka (2006)
J. Immunol. 176, 7-11
   Abstract »    Full Text »    PDF »
Cancer Cells Become Susceptible to Natural Killer Cell Killing after Exposure to Histone Deacetylase Inhibitors Due to Glycogen Synthase Kinase-3-Dependent Expression of MHC Class I-Related Chain A and B.
S. Skov, M. T. Pedersen, L. Andresen, P. Thor Straten, A. Woetmann, and N. Odum (2005)
Cancer Res. 65, 11136-11145
   Abstract »    Full Text »    PDF »
The Biology of {gamma}{delta} T Cells: What Is the Relationship between {gamma}{delta} T Cells and Cancer? Will an Increased Number and/or Function of {gamma}{delta} T Cells Result in Lower Cancer Incidence?.
W. L. Havran (2005)
J. Nutr. 135, 2909S
   Full Text »    PDF »
JNK1 Is Essential for CD8+ T Cell-Mediated Tumor Immune Surveillance.
Y. Gao, J. Tao, M. O. Li, D. Zhang, H. Chi, O. Henegariu, S. M. Kaech, R. J. Davis, R. A. Flavell, and Z. Yin (2005)
J. Immunol. 175, 5783-5789
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882