Mariana Lagos-Quintana, Reinhard Rauhut, Winfried Lendeckel, Thomas Tuschl^*

In Caenorhabditis elegans, lin-4 and let-7 encode 22- and 21-nucleotide (nt) RNAs, respectively, which function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as small temporal RNAs (stRNAs). We show that many 21- and 22-nt expressed RNAs, termed microRNAs, exist in invertebrates and vertebrates and that some of these novel RNAs, similar to let-7 stRNA, are highly conserved. This suggests that sequence-specific, posttranscriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.

Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D-37077 Göttingen, Germany.
^*   To whom correspondence should be addressed. E-mail: ttuschl{at}mpibpc.gwdg.de

Neuroendocrine tumours: cracking the epigenetic code.

A. Karpathakis, H. Dibra, and C. Thirlwell (2013)
Endocr. Relat. Cancer 20, R65-R82
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MicroRNA-146a Negatively Regulates the Immunoregulatory Activity of Bone Marrow Stem Cells by Targeting Prostaglandin E2 Synthase-2.

M. Matysiak, M. Fortak-Michalska, B. Szymanska, W. Orlowski, A. Jurewicz, and K. Selmaj (2013)
J. Immunol. 190, 5102-5109
 |  Abstract »  |  Full Text »  |  PDF »

MicroRNAs in flow-dependent vascular remodelling.

P. Neth, M. Nazari-Jahantigh, A. Schober, and C. Weber (2013)
Cardiovasc Res
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Dicer1 Is Required to Repress Neuronal Fate During Endocrine Cell Maturation.

M. S. Kanji, M. G. Martin, and A. Bhushan (2013)
Diabetes 62, 1602-1611
 |  Abstract »  |  Full Text »  |  PDF »

Transient RNA structure features are evolutionarily conserved and can be computationally predicted.

J. Y. A. Zhu, A. Steif, J. R. Proctor, and I. M. Meyer (2013)
Nucleic Acids Res.
 |  Abstract »  |  Full Text »  |  PDF »

Global profiling of miRNAs and the hairpin precursors: insights into miRNA processing and novel miRNA discovery.

N. Li, X. You, T. Chen, S. D. Mackowiak, M. R. Friedlander, M. Weigt, H. Du, A. Gogol-Doring, Z. Chang, C. Dieterich, et al. (2013)
Nucleic Acids Res. 41, 3619-3634
 |  Abstract »  |  Full Text »  |  PDF »

Minireview: MIRomics in Endocrinology: A Novel Approach for Modeling Endocrine Diseases.

P. M. Szabo, H. Butz, P. Igaz, K. Racz, L. Hunyady, and A. Patocs (2013)
Mol. Endocrinol. 27, 573-585
 |  Abstract »  |  Full Text »  |  PDF »

MicroRNA23a and MicroRNA23b Deregulation Derepresses SF-1 and Upregulates Estrogen Signaling in Ovarian Endometriosis.

L. Shen, S. Yang, W. Huang, W. Xu, Q. Wang, Y. Song, and Y. Liu (2013)
J. Clin. Endocrinol. Metab. 98, 1575-1582
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Cystic Fibrosis Transmembrane Conductance Regulator by MicroRNA-145, -223, and -494 Is Altered in {Delta}F508 Cystic Fibrosis Airway Epithelium.

I. K. Oglesby, S. H. Chotirmall, N. G. McElvaney, and C. M. Greene (2013)
J. Immunol. 190, 3354-3362
 |  Abstract »  |  Full Text »  |  PDF »

LIN-41/TRIM71: emancipation of a miRNA target.

M. Ecsedi and H. Grosshans (2013)
Genes & Dev. 27, 581-589
 |  Abstract »  |  Full Text »  |  PDF »

MicroRNA miR-24 enhances tumor invasion and metastasis by targeting PTPN9 and PTPRF to promote EGF signaling.

W. W. Du, L. Fang, M. Li, X. Yang, Y. Liang, C. Peng, W. Qian, Y. Q. O'Malley, R. W. Askeland, S. L. Sugg, et al. (2013)
J. Cell Sci. 126, 1440-1453
 |  Abstract »  |  Full Text »  |  PDF »

MicroRNAs and respiratory diseases.

H. Rupani, T. Sanchez-Elsner, and P. Howarth (2013)
Eur. Respir. J. 41, 695-705
 |  Abstract »  |  Full Text »  |  PDF »

Rat mir-155 generated from the lncRNA Bic is 'hidden' in the alternate genomic assembly and reveals the existence of novel mammalian miRNAs and clusters.

P. Uva, L. Da Sacco, M. Del Corno, A. Baldassarre, P. Sestili, M. Orsini, A. Palma, S. Gessani, and A. Masotti (2013)
RNA 19, 365-379
 |  Abstract »  |  Full Text »  |  PDF »

Paediatric pharmacogenomics: an overview.

D. B. Hawcutt, B. Thompson, R. L. Smyth, and M. Pirmohamed (2013)
Arch. Dis. Child. 98, 232-237
 |  Abstract »  |  Full Text »  |  PDF »

Epigenetics and Psychostimulant Addiction.

H. D. Schmidt, J. F. McGinty, A. E. West, and G. Sadri-Vakili (2013)
Cold Spring Harb Perspect Med 3, a012047
 |  Abstract »  |  Full Text »  |  PDF »

MicroRNA 339 down-regulates {mu}-opioid receptor at the post-transcriptional level in response to opioid treatment.

Q. Wu, C. K. Hwang, H. Zheng, Y. Wagley, H.-Y. Lin, D. K. Kim, P.-Y. Law, H. H. Loh, and L.-N. Wei (2013)
FASEB J 27, 522-535
 |  Abstract »  |  Full Text »  |  PDF »

miRNA-145 Targets v-ets Erythroblastosis Virus E26 Oncogene Homolog 1 to Suppress the Invasion, Metastasis, and Angiogenesis of Gastric Cancer Cells.

L. Zheng, J. Pu, T. Qi, M. Qi, D. Li, X. Xiang, K. Huang, and Q. Tong (2013)
Mol. Cancer Res. 11, 182-193
 |  Abstract »  |  Full Text »  |  PDF »

Reconsideration of in silico siRNA design from a perspective of heterogeneous data integration: problems and solutions.

Q. Liu, H. Zhou, R. Zhu, Y. Xu, and Z. Cao (2012)
Brief Bioinform
 |  Abstract »  |  Full Text »  |  PDF »

The role of MicroRNAs miR-200b and miR-200c in TLR4 signaling and NF-{kappa}B activation.

E. B. Wendlandt, J. W. Graff, T. L. Gioannini, A. P. McCaffrey, and M. E. Wilson (2012)
Innate Immunity 18, 846-855
 |  Abstract »  |  Full Text »  |  PDF »

miR-1 and miR-206 regulate angiogenesis by modulating VegfA expression in zebrafish.

C. Stahlhut, Y. Suarez, J. Lu, Y. Mishima, and A. J. Giraldez (2012)
Development 139, 4356-4365
 |  Abstract »  |  Full Text »  |  PDF »

Does base-pairing strength play a role in microRNA repression?.

I. Carmel, N. Shomron, and Y. Heifetz (2012)
RNA 18, 1947-1956
 |  Abstract »  |  Full Text »  |  PDF »

Discovering the first microRNA-targeted drug.

M. Lindow and S. Kauppinen (2012)
J. Cell Biol. 199, 407-412
 |  Abstract »  |  Full Text »  |  PDF »

Regulatory RNAs in the light of Drosophila genomics.

A. Marco (2012)
Briefings in Functional Genomics
 |  Abstract »  |  Full Text »  |  PDF »

Discovery of hundreds of mirtrons in mouse and human small RNA data.

E. Ladewig, K. Okamura, A. S. Flynt, J. O. Westholm, and E. C. Lai (2012)
Genome Res. 22, 1634-1645
 |  Abstract »  |  Full Text »  |  PDF »

Integrative analysis of gene and miRNA expression profiles with transcription factor-miRNA feed-forward loops identifies regulators in human cancers.

Z. Yan, P. K. Shah, S. B. Amin, M. K. Samur, N. Huang, X. Wang, V. Misra, H. Ji, D. Gabuzda, and C. Li (2012)
Nucleic Acids Res. 40, e135
 |  Abstract »  |  Full Text »  |  PDF »

DNA methylation of microRNA genes in multiple myeloma.

K. Y. Wong, X. Huang, and C. S. Chim (2012)
Carcinogenesis 33, 1629-1638
 |  Abstract »  |  Full Text »  |  PDF »

mdv1-miR-M7-5p, located in the newly identified first intron of the latency-associated transcript of Marek's disease virus, targets the immediate-early genes ICP4 and ICP27.

S. Strassheim, G. Stik, D. Rasschaert, and S. Laurent (2012)
J. Gen. Virol. 93, 1731-1742
 |  Abstract »  |  Full Text »  |  PDF »

A genome-wide transgenic resource for conditional expression of Drosophila microRNAs.

F. Bejarano, D. Bortolamiol-Becet, Q. Dai, K. Sun, A. Saj, Y.-T. Chou, D. R. Raleigh, K. Kim, J.-Q. Ni, H. Duan, et al. (2012)
Development 139, 2821-2831
 |  Abstract »  |  Full Text »  |  PDF »

MicroRNAs in the Pineal Gland: miR-483 REGULATES MELATONIN SYNTHESIS BY TARGETING ARYLALKYLAMINE N-ACETYLTRANSFERASE.

S. J. H. Clokie, P. Lau, H. H. Kim, S. L. Coon, and D. C. Klein (2012)
J. Biol. Chem. 287, 25312-25324
 |  Abstract »  |  Full Text »  |  PDF »

Mechanical loading and TGF-{beta} change the expression of multiple miRNAs in tendon fibroblasts.

C. L. Mendias, J. P. Gumucio, and E. B. Lynch (2012)
J Appl Physiol 113, 56-62
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for a cytoplasmic microprocessor of pri-miRNAs.

J. S. Shapiro, R. A. Langlois, A. M. Pham, and B. R. tenOever (2012)
RNA 18, 1338-1346
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of microRNA-375 by cAMP in Pancreatic {beta}-Cells.

D. M. Keller, E. A. Clark, and R. H. Goodman (2012)
Mol. Endocrinol. 26, 989-999
 |  Abstract »  |  Full Text »  |  PDF »

LocARNA-P: Accurate boundary prediction and improved detection of structural RNAs.

S. Will, T. Joshi, I. L. Hofacker, P. F. Stadler, and R. Backofen (2012)
RNA 18, 900-914
 |  Abstract »  |  Full Text »  |  PDF »

Performance comparison and evaluation of software tools for microRNA deep-sequencing data analysis.

Y. Li, Z. Zhang, F. Liu, W. Vongsangnak, Q. Jing, and B. Shen (2012)
Nucleic Acids Res. 40, 4298-4305
 |  Abstract »  |  Full Text »  |  PDF »

MicroRNA-214 Suppresses Growth and Invasiveness of Cervical Cancer Cells by Targeting UDP-N-acetyl-{alpha}-D-galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 7.

R.-Q. Peng, H.-Y. Wan, H.-F. Li, M. Liu, X. Li, and H. Tang (2012)
J. Biol. Chem. 287, 14301-14309
 |  Abstract »  |  Full Text »  |  PDF »

MicroRNA-212 displays tumor-promoting properties in non-small cell lung cancer cells and targets the hedgehog pathway receptor PTCH1.

Y. Li, D. Zhang, C. Chen, Z. Ruan, Y. Li, and Y. Huang (2012)
Mol. Biol. Cell 23, 1423-1434
 |  Abstract »  |  Full Text »  |  PDF »

Monoallelic and Biallelic Deletions of 13q14.3 in Chronic Lymphocytic Leukemia: FISH vs miRNA RT-qPCR Detection.

M. T. Smonskey, A. W. Block, G. Deeb, A. A. Chanan-Khan, Z. P. Bernstein, K. C. Miller, P. K. Wallace, and P. Starostik (2012)
Am J Clin Pathol 137, 641-646
 |  Abstract »  |  Full Text »  |  PDF »

Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens.

V. A. Meliopoulos, L. E. Andersen, K. F. Birrer, K. J. Simpson, J. W. Lowenthal, A. G. D. Bean, J. Stambas, C. R. Stewart, S. M. Tompkins, V. W. van Beusechem, et al. (2012)
FASEB J 26, 1372-1386
 |  Abstract »  |  Full Text »  |  PDF »

miR-30 Family Members Negatively Regulate Osteoblast Differentiation.

T. Wu, H. Zhou, Y. Hong, J. Li, X. Jiang, and H. Huang (2012)
J. Biol. Chem. 287, 7503-7511
 |  Abstract »  |  Full Text »  |  PDF »

Decoding the Cardiac Message: The 2011 Thomas W. Smith Memorial Lecture.

G. W. Dorn II (2012)
Circ. Res. 110, 755-763
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MECHANISMS IN ENDOCRINOLOGY: Micro-RNAs: targets for enhancing osteoblast differentiation and bone formation.

H. Taipaleenmaki, L. Bjerre Hokland, L. Chen, S. Kauppinen, and M. Kassem (2012)
Eur. J. Endocrinol. 166, 359-371
 |  Abstract »  |  Full Text »  |  PDF »

Introduction to the Series on MicroRNAs in the Cardiovascular System.

E. van Rooij (2012)
Circ. Res. 110, 481-482
 |  Abstract »  |  Full Text »  |  PDF »

Managing Microvascular Complications of Diabetes with MicroRNAs.

S. S. Badal and F. R. Danesh (2012)
J. Am. Soc. Nephrol. 23, 185-187
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MicroRNAs are shaping the hematopoietic landscape.

U. Bissels, A. Bosio, and W. Wagner (2012)
Haematologica 97, 160-167
 |  Abstract »  |  Full Text »  |  PDF »

MicroRNAs Associated with Mitogen-Activated Protein Kinase in Human Pancreatic Cancer.

Y. Ikeda, E. Tanji, N. Makino, S. Kawata, and T. Furukawa (2012)
Mol. Cancer Res. 10, 259-269
 |  Abstract »  |  Full Text »  |  PDF »

miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades.

M. R. Friedlander, S. D. Mackowiak, N. Li, W. Chen, and N. Rajewsky (2012)
Nucleic Acids Res. 40, 37-52
 |  Abstract »  |  Full Text »  |  PDF »

Identification and characterization of microRNA from chicken adipose tissue and skeletal muscle.

X. G. Wang, J. F. Yu, Y. Zhang, D. Q. Gong, and Z. L. Gu (2012)
Poult. Sci. 91, 139-149
 |  Abstract »  |  Full Text »  |  PDF »

Hypothalamic EAP1 (Enhanced at Puberty 1) Is Required for Menstrual Cyclicity in Nonhuman Primates.

G. A. Dissen, A. Lomniczi, S. Heger, T. L. Neff, and S. R. Ojeda (2012)
Endocrinology 153, 350-361
 |  Abstract »  |  Full Text »  |  PDF »

A Combined Array-Based Comparative Genomic Hybridization and Functional Library Screening Approach Identifies mir-30d As an Oncomir in Cancer.

N. Li, S. Kaur, J. Greshock, H. Lassus, X. Zhong, Y. Wang, A. Leminen, Z. Shao, X. Hu, S. Liang, et al. (2012)
Cancer Res. 72, 154-164
 |  Abstract »  |  Full Text »  |  PDF »

RNA-Based Immunity Terminates Viral Infection in Adult Drosophila in the Absence of Viral Suppression of RNA Interference: Characterization of Viral Small Interfering RNA Populations in Wild-Type and Mutant Flies.

Y.-H. Han, Y.-J. Luo, Q. Wu, J. Jovel, X.-H. Wang, R. Aliyari, C. Han, W.-X. Li, and S.-W. Ding (2011)
J. Virol. 85, 13153-13163
 |  Abstract »  |  Full Text »  |  PDF »

A bias-reducing strategy in profiling small RNAs using Solexa.

G. Sun, X. Wu, J. Wang, H. Li, X. Li, H. Gao, J. Rossi, and Y. Yen (2011)
RNA 17, 2256-2262
 |  Abstract »  |  Full Text »  |  PDF »

A liver-specific microRNA binds to a highly conserved RNA sequence of hepatitis B virus and negatively regulates viral gene expression and replication.

Y. Chen, A. Shen, P. J. Rider, Y. Yu, K. Wu, Y. Mu, Q. Hao, Y. Liu, H. Gong, Y. Zhu, et al. (2011)
FASEB J 25, 4511-4521
 |  Abstract »  |  Full Text »  |  PDF »

Reduced miR-128 in Breast Tumor-Initiating Cells Induces Chemotherapeutic Resistance via Bmi-1 and ABCC5.

Y. Zhu, F. Yu, Y. Jiao, J. Feng, W. Tang, H. Yao, C. Gong, J. Chen, F. Su, Y. Zhang, et al. (2011)
Clin. Cancer Res. 17, 7105-7115
 |  Abstract »  |  Full Text »  |  PDF »

RNAcentral: A vision for an international database of RNA sequences.

A. Bateman, S. Agrawal, E. Birney, E. A. Bruford, J. M. Bujnicki, G. Cochrane, J. R. Cole, M. E. Dinger, A. J. Enright, P. P. Gardner, et al. (2011)
RNA 17, 1941-1946
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Deep sequencing of small RNAs from human skin reveals major alterations in the psoriasis miRNAome.

C. E. Joyce, X. Zhou, J. Xia, C. Ryan, B. Thrash, A. Menter, W. Zhang, and A. M. Bowcock (2011)
Hum. Mol. Genet. 20, 4025-4040
 |  Abstract »  |  Full Text »  |  PDF »

MicroRNA-155 Promotes Resolution of Hypoxia-Inducible Factor 1{alpha} Activity during Prolonged Hypoxia.

U. Bruning, L. Cerone, Z. Neufeld, S. F. Fitzpatrick, A. Cheong, C. C. Scholz, D. A. Simpson, M. O. Leonard, M. M. Tambuwala, E. P. Cummins, et al. (2011)
Mol. Cell. Biol. 31, 4087-4096
 |  Abstract »  |  Full Text »  |  PDF »

MicroRNA133a: A New Variable in Vascular Smooth Muscle Cell Phenotypic Switching.

J. M. Miano and E. M. Small (2011)
Circ. Res. 109, 825-827
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cis-Acting Effects on RNA Processing and Drosha Cleavage Prevent Epstein-Barr Virus Latency III BHRF1 Expression.

L. Xing and E. Kieff (2011)
J. Virol. 85, 8929-8939
 |  Abstract »  |  Full Text »  |  PDF »

mir-11 limits the proapoptotic function of its host gene, dE2f1.

M. Truscott, A. B. M. M. K. Islam, N. Lopez-Bigas, and M. V. Frolov (2011)
Genes & Dev. 25, 1820-1834
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Protective conditioning of the brain: expressway or roadblock?.

P. Mergenthaler and U. Dirnagl (2011)
J. Physiol. 589, 4147-4155
 |  Abstract »  |  Full Text »  |  PDF »

Selection Fine-Tunes the Expression of MicroRNA Target Genes in Arabidopsis thaliana.

S. Takuno and H. Innan (2011)
Mol. Biol. Evol. 28, 2429-2434
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Small Noncoding RNAs in the Germline.

J. P. Saxe and H. Lin (2011)
Cold Spring Harb Perspect Biol 3, a002717
 |  Abstract »  |  Full Text »  |  PDF »

'Inc-miRs': functional intron-interrupted miRNA genes.

H. Zhang, J. M. Maniar, and A. Z. Fire (2011)
Genes & Dev. 25, 1589-1594
 |  Abstract »  |  Full Text »  |  PDF »

MicroRNA-372 Is Down-regulated and Targets Cyclin-dependent Kinase 2 (CDK2) and Cyclin A1 in Human Cervical Cancer, Which May Contribute to Tumorigenesis.

R.-Q. Tian, X.-H. Wang, L.-J. Hou, W.-H. Jia, Q. Yang, Y.-X. Li, M. Liu, X. Li, and H. Tang (2011)
J. Biol. Chem. 286, 25556-25563
 |  Abstract »  |  Full Text »  |  PDF »

MicroRNAs in Development and Disease.

D. Sayed and M. Abdellatif (2011)
Physiol Rev 91, 827-887
 |  Abstract »  |  Full Text »  |  PDF »

The type II poly(A)-binding protein PABP-2 genetically interacts with the let-7 miRNA and elicits heterochronic phenotypes in Caenorhabditis elegans.

B. A. Hurschler, D. T. Harris, and H. Grosshans (2011)
Nucleic Acids Res. 39, 5647-5657
 |  Abstract »  |  Full Text »  |  PDF »

The power of Pasteur's quadrant: cardiovascular disease at the turn of the century.

R. I. Levin and G. I. Fishman (2011)
FASEB J 25, 1788-1792
 |  Abstract »  |  Full Text »  |  PDF »

MicroRNAs: new players in the DNA damage response.

H. Hu and R. A. Gatti (2011)
J Mol Cell Biol 3, 151-158
 |  Abstract »  |  Full Text »  |  PDF »

Potent and systematic RNAi mediated silencing with single oligonucleotide compounds.

J. Lapierre, W. Salomon, J. Cardia, K. Bulock, J. T. Lam, W. J. Stanney, G. Ford, B. Smith-Anzures, T. Woolf, J. Kamens, et al. (2011)
RNA 17, 1032-1037
 |  Abstract »  |  Full Text »  |  PDF »

MicroRNA in central nervous system trauma and degenerative disorders.

N.-K. Liu and X.-M. Xu (2011)
Physiol Genomics 43, 571-580
 |  Abstract »  |  Full Text »  |  PDF »

Non-invasive aneuploidy detection using free fetal DNA and RNA in maternal plasma: recent progress and future possibilities.

A. T. J. I. Go, J. M. G. van Vugt, and C. B. M. Oudejans (2011)
Hum. Reprod. Update 17, 372-382
 |  Abstract »  |  Full Text »  |  PDF »

MicroRNA-145 is regulated by DNA methylation and p53 gene mutation in prostate cancer.

S. O. Suh, Y. Chen, M. S. Zaman, H. Hirata, S. Yamamura, V. Shahryari, J. Liu, Z. L. Tabatabai, S. Kakar, G. Deng, et al. (2011)
Carcinogenesis 32, 772-778
 |  Abstract »  |  Full Text »  |  PDF »

Phosphoglucose Isomerase/Autocrine Motility Factor Mediates Epithelial-Mesenchymal Transition Regulated by miR-200 in Breast Cancer Cells.

A. Ahmad, A. Aboukameel, D. Kong, Z. Wang, S. Sethi, W. Chen, F. H. Sarkar, and A. Raz (2011)
Cancer Res. 71, 3400-3409
 |  Abstract »  |  Full Text »  |  PDF »

SplamiR--prediction of spliced miRNAs in plants.

C. J. Thieme, L. Gramzow, D. Lobbes, and G. Theissen (2011)
Bioinformatics 27, 1215-1223
 |  Abstract »  |  Full Text »  |  PDF »

Improved annotation of C. elegans microRNAs by deep sequencing reveals structures associated with processing by Drosha and Dicer.

M. B. Warf, W. E. Johnson, and B. L. Bass (2011)
RNA 17, 563-577
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The Second RNA Chaperone, Hfq2, Is Also Required for Survival under Stress and Full Virulence of Burkholderia cenocepacia J2315.

C. G. Ramos, S. A. Sousa, A. M. Grilo, J. R. Feliciano, and J. H. Leitao (2011)
J. Bacteriol. 193, 1515-1526
 |  Abstract »  |  Full Text »  |  PDF »

MicroRNA in Osteoarthritis.

C. Yu, W.-P. Chen, and X.-H. Wang (2011)
Journal of International Medical Research 39, 1-9
 |  Abstract »  |  PDF »

Polycomb preferentially targets stalled promoters of coding and noncoding transcripts.

D. Enderle, C. Beisel, M. B. Stadler, M. Gerstung, P. Athri, and R. Paro (2011)
Genome Res. 21, 216-226
 |  Abstract »  |  Full Text »  |  PDF »

Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence.

E. Berezikov, N. Robine, A. Samsonova, J. O. Westholm, A. Naqvi, J.-H. Hung, K. Okamura, Q. Dai, D. Bortolamiol-Becet, R. Martin, et al. (2011)
Genome Res. 21, 203-215
 |  Abstract »  |  Full Text »  |  PDF »

MicroRNA and Mechanisms of Impaired Angiogenesis in Diabetes Mellitus.

N. J. Leeper and J. P. Cooke (2011)
Circulation 123, 236-238
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The Art of MicroRNA Research.

E. van Rooij (2011)
Circ. Res. 108, 219-234
 |  Abstract »  |  Full Text »  |  PDF »

Human box C/D snoRNAs with miRNA like functions: expanding the range of regulatory RNAs.

M. Brameier, A. Herwig, R. Reinhardt, L. Walter, and J. Gruber (2011)
Nucleic Acids Res. 39, 675-686
 |  Abstract »  |  Full Text »  |  PDF »

p53 activates the PANK1/miRNA-107 gene leading to downregulation of CDK6 and p130 cell cycle proteins.

L. Bohlig, M. Friedrich, and K. Engeland (2011)
Nucleic Acids Res. 39, 440-453
 |  Abstract »  |  Full Text »  |  PDF »

Identification of MicroRNAs Regulating Reprogramming Factor LIN28 in Embryonic Stem Cells and Cancer Cells.

X. Zhong, N. Li, S. Liang, Q. Huang, G. Coukos, and L. Zhang (2010)
J. Biol. Chem. 285, 41961-41971
 |  Abstract »  |  Full Text »  |  PDF »

Computational approaches for RNA energy parameter estimation.

M. Andronescu, A. Condon, H. H. Hoos, D. H. Mathews, and K. P. Murphy (2010)
RNA 16, 2304-2318
 |  Abstract »  |  Full Text »  |  PDF »

Protein expression analysis of chronic lymphocytic leukemia defines the effect of genetic aberrations and uncovers a correlation of CDK4, P27 and P53 with hierarchical risk.

D. Winkler, C. Schneider, M. Zucknick, D. Bogelein, K. Schulze, T. Zenz, J. Mohr, A. Philippen, H. Huber, A. Buhler, et al. (2010)
Haematologica 95, 1880-1888
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of microRNA knockouts in mice.

C. Y. Park, Y. S. Choi, and M. T. McManus (2010)
Hum. Mol. Genet. 19, R169-R175
 |  Abstract »  |  Full Text »  |  PDF »

High-Risk Human Papillomavirus Reduces the Expression of MicroRNA-218 in Women with Cervical Intraepithelial Neoplasia.

Y. Li, J. Liu, C. Yuan, B. Cui, X. Zou, and Y. Qiao (2010)
Journal of International Medical Research 38, 1730-1736
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