Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Abnormal Vascular Function and Hypertension in Mice Deficient in Estrogen Receptor
Yan Zhu,1Zhao Bian,23Ping Lu,1Richard H. Karas,1Lin Bao,1Daniel Cox,1Jeffrey Hodgin,4Philip W. Shaul,5Peter Thorén,3Oliver Smithies,4Jan-Åke Gustafsson,2Michael E. Mendelsohn1*
Blood vessels express estrogen receptors, but their role
in cardiovascular physiology is not well understood. We show thatvascular smooth muscle cells and blood vessels from estrogen receptor (ER)-deficient mice exhibit multiple functional abnormalities.In wild-type mouse blood vessels, estrogen attenuates vasoconstrictionby an ER-mediated increase in inducible nitric oxide synthaseexpression. In contrast, estrogen augments vasoconstriction inblood
vessels from ER-deficient mice. Vascular smooth musclecells
isolated from ER-deficient mice show multiple abnormalitiesof ion
channel function. Furthermore, ER-deficient mice developsustained
systolic and diastolic hypertension as they age. Thesedata support an
essential role for ER in the regulation of vascularfunction and
blood pressure.
1 Molecular Cardiology Research Institute, New
England Medical Center and Department of Medicine, Tufts University
School of Medicine, Boston, MA 02111, USA.
2 Department of Medical Nutrition and Center for
Biotechnology, Novum, Huddinge University Hospital, 141 86 Huddinge,
Sweden.
3 Department of Physiology and Pharmacology,
171 77, Karolinska Institute, Stockholm, Sweden.
4 Department of Pathology, University of North
Carolina, Chapel Hill, NC 27599, USA.
5 Department
of Pediatrics, University of Texas Southwestern Medical Center, Dallas,
TX 75390, USA.
*
To whom correspondence should be addressed. E-mail:
mmendelsohn{at}lifespan.org
The editors suggest the following Related Resources on Science sites:
Is {beta} the {alpha} Dog in Estrogen Receptor-Mediated Protection From Hypertension?.
K. Sandberg and H. Ji (2013)
Hypertension
61, 1153-1154
|Full Text »|PDF »
Estrogen Receptor-{beta} in the Paraventricular Nucleus and Rostroventrolateral Medulla Plays an Essential Protective Role in Aldosterone/Salt-Induced Hypertension in Female Rats.
B. Xue, Z. Zhang, T. G. Beltz, R. F. Johnson, F. Guo, M. Hay, and A. K. Johnson (2013)
Hypertension
61, 1255-1262
|Abstract »|Full Text »|PDF »
Effects of testosterone on cardiomyocyte calcium homeostasis and contractile function in female rats.
R. D. Beesley, B. M. Palmer, P. R. Casson, and M. J. Toth (2013)
Exp Physiol
98, 161-171
|Abstract »|Full Text »|PDF »
Sexual Dimorphism: The Aging Kidney, Involvement of Nitric Oxide Deficiency, and Angiotensin II Overactivity.
Rapid Estrogen Receptor Signaling Is Essential for the Protective Effects of Estrogen Against Vascular Injury.
S. J. Bernelot Moens, G. R. Schnitzler, M. Nickerson, H. Guo, K. Ueda, Q. Lu, M. J. Aronovitz, H. Nickerson, W. E. Baur, U. Hansen, et al. (2012)
Circulation
126, 1993-2004
|Abstract »|Full Text »|PDF »
Associations of Bisphenol A Exposure With Heart Rate Variability and Blood Pressure.
S. Bae, J. H. Kim, Y.-H. Lim, H. Y. Park, and Y.-C. Hong (2012)
Hypertension
60, 786-793
|Abstract »|Full Text »|PDF »
Estrogen Paradox in Pulmonary Hypertension: Current Controversies and Future Perspectives.
Deletion of G Protein-Coupled Estrogen Receptor Increases Endothelial Vasoconstriction.
M. R. Meyer, K. Amann, A. S. Field, C. Hu, H. J. Hathaway, N. L. Kanagy, M. K. Walker, M. Barton, and E. R. Prossnitz (2012)
Hypertension
59, 507-512
|Abstract »|Full Text »|PDF »
Minireview: Recent Advances in Extranuclear Steroid Receptor Actions.
AMPK Alpha 1-Induced RhoA Phosphorylation Mediates Vasoprotective Effect of Estradiol.
M. Gayard, C. Guilluy, A. Rousselle, B. Viollet, D. Henrion, P. Pacaud, G. Loirand, and M. Rolli-Derkinderen (2011)
Arterioscler Thromb Vasc Biol
31, 2634-2642
|Abstract »|Full Text »|PDF »
Estrogen Receptor-{beta} and Fetoplacental Endothelial Prostanoid Biosynthesis: A Link to Clinically Demonstrated Fetal Growth Restriction.
E. J. Su, L. Ernst, N. Abdallah, R. Chatterton, H. Xin, D. Monsivais, J. Coon, and S. E. Bulun (2011)
J. Clin. Endocrinol. Metab.
96, E1558-E1567
|Abstract »|Full Text »|PDF »
Estrogen Rescues Preexisting Severe Pulmonary Hypertension in Rats.
S. Umar, A. Iorga, H. Matori, R. D. Nadadur, J. Li, F. Maltese, A. van der Laarse, and M. Eghbali (2011) 184, 715-723
|Abstract »|Full Text »|PDF »
Inducible nitric oxide synthase provides protection against injury-induced thrombosis in female mice.
R. K. Upmacis, H. Shen, L. E. S. Benguigui, B. D. Lamon, R. S. Deeb, K. A. Hajjar, and D. P. Hajjar (2011)
Am J Physiol Heart Circ Physiol
301, H617-H624
|Abstract »|Full Text »|PDF »
Estrogen Receptor-{beta} Signals Left Ventricular Hypertrophy Sex Differences in Normotensive Deoxycorticosterone Acetate-Salt Mice.
D. Gurgen, B. Hegner, A. Kusch, R. Catar, L. Chaykovska, U. Hoff, V. Gross, T. Slowinski, A. C. da Costa Goncalves, U. Kintscher, et al. (2011)
Hypertension
57, 648-654
|Abstract »|Full Text »|PDF »
A. Pedram, M. Razandi, F. O'Mahony, D. Lubahn, and E. R. Levin (2010)
Mol. Endocrinol.
24, 2152-2165
|Abstract »|Full Text »|PDF »
Renal Actions of RGS2 Control Blood Pressure.
S. B. Gurley, R. C. Griffiths, M. E. Mendelsohn, R. H. Karas, and T. M. Coffman (2010)
J. Am. Soc. Nephrol.
21, 1847-1851
|Abstract »|Full Text »|PDF »
Estradiol Stimulates Capillary Formation by Human Endothelial Progenitor Cells: Role of Estrogen Receptor-{alpha}/{beta}, Heme Oxygenase 1, and Tyrosine Kinase.
I. Baruscotti, F. Barchiesi, E. K. Jackson, B. Imthurn, R. Stiller, J.-H. Kim, S. Schaufelberger, M. Rosselli, C. C. W. Hughes, and R. K. Dubey (2010)
Hypertension
56, 397-404
|Abstract »|Full Text »|PDF »
Estrogen Receptors and Endothelium.
J.-F. Arnal, C. Fontaine, A. Billon-Gales, J. Favre, H. Laurell, F. Lenfant, and P. Gourdy (2010)
Arterioscler Thromb Vasc Biol
30, 1506-1512
|Abstract »|Full Text »|PDF »
Review: Gender Differences in Cardiovascular Disease: Hormonal and Biochemical Influences.
F. R. Perez-Lopez, L. Larrad-Mur, A. Kallen, P. Chedraui, and H. S. Taylor (2010)
Reproductive Sciences
17, 511-531
|Abstract »|PDF »
Reduction in incidence and fatality of out-of-hospital cardiac arrest in females of the reproductive age.
T. Kitamura, T. Iwami, G. Nichol, T. Nishiuchi, Y. Hayashi, C. Nishiyama, T. Sakai, K. Kajino, A. Hiraide, H. Ikeuchi, et al. (2010)
Eur. Heart J.
31, 1365-1372
|Abstract »|Full Text »|PDF »
Estrogen Receptor {beta} Agonism Increases Survival in Experimentally Induced Sepsis and Ameliorates the Genomic Sepsis Signature: A Pharmacogenomic Study.
E. Christaki, S. M. Opal, J. C. Keith Jr, N. Kessinian, J. E. Palardy, N. A. Parejo, E. Lavallie, L. Racie, W. Mounts, M. S. Malamas, et al. (2010)
The Journal of Infectious Disease
201, 1250-1257
|Abstract »|Full Text »|PDF »
Claudin-5 as a Novel Estrogen Target in Vascular Endothelium.
M. Burek, P. A. Arias-Loza, N. Roewer, and C. Y. Forster (2010)
Arterioscler Thromb Vasc Biol
30, 298-304
|Abstract »|Full Text »|PDF »
Regulation of Vascular Contractility and Blood Pressure by the E2F2 Transcription Factor.
J. Zhou, Y. Zhu, M. Cheng, D. Dinesh, T. Thorne, K. K. Poh, D. Liu, C. Botros, Y. L. Tang, N. Reisdorph, et al. (2009)
Circulation
120, 1213-1221
|Abstract »|Full Text »|PDF »
ER{alpha}, ER{beta}, and gpER: novel aspects of oestrogen receptor signalling in atherosclerosis.
M. R. Meyer and M. Barton (2009)
Cardiovasc Res
83, 605-610
|Full Text »|PDF »
Estrogen receptor {beta} gene mutations in Indian infertile men.
A. Khattri, R.K. Pandey, N.J. Gupta, B. Chakravarty, M. Deenadayal, L. Singh, and K. Thangaraj (2009)
Mol. Hum. Reprod.
15, 513-520
|Abstract »|Full Text »|PDF »
Transcriptional changes in blood after aerobic interval training in patients with the metabolic syndrome.
A. Bye, A. E. Tjonna, T. O. Stolen, R. E. N. Rosbjorgen, and U. Wisloff (2009)
European Journal of Cardiovascular Prevention & Rehabilitation
16, 47-52
|Abstract »|Full Text »|PDF »
Coactivation of Estrogen Receptor {beta} by Gonadotropin-Induced Cofactor GIOT-4.
M. Kouzu-Fujita, Y. Mezaki, S. Sawatsubashi, T. Matsumoto, I. Yamaoka, T. Yano, Y. Taketani, H. Kitagawa, and S. Kato (2009)
Mol. Cell. Biol.
29, 83-92
|Abstract »|Full Text »|PDF »
Distinct Roles of Estrogen Receptor-{alpha} and {beta} in the Modulation of Vascular Inducible Nitric-Oxide Synthase in Diabetes.
A. Cignarella, C. Bolego, V. Pelosi, C. Meda, A. Krust, C. Pinna, R. M. Gaion, E. Vegeto, and A. Maggi (2009)
J. Pharmacol. Exp. Ther.
328, 174-182
|Abstract »|Full Text »|PDF »
Increased blood pressure in mice lacking cytochrome P450 2J5.
K. Athirakul, J. A. Bradbury, J. P. Graves, L. M. DeGraff, J. Ma, Y. Zhao, J. F. Couse, R. Quigley, D. R. Harder, X. Zhao, et al. (2008)
FASEB J
22, 4096-4108
|Abstract »|Full Text »|PDF »
Differential regulation of the inducible nitric oxide synthase gene by estrogen receptors 1 and 2.
S. Tsutsumi, X. Zhang, K. Takata, K. Takahashi, R. H Karas, H. Kurachi, and M. E Mendelsohn (2008)
J. Endocrinol.
199, 267-273
|Abstract »|Full Text »|PDF »
Research Resource: Rapid Recruitment of Temporally Distinct Vascular Gene Sets by Estrogen.
K. K. Schnoes, I. Z. Jaffe, L. Iyer, A. Dabreo, M. Aronovitz, B. Newfell, U. Hansen, G. Rosano, and M. E. Mendelsohn (2008)
Mol. Endocrinol.
22, 2544-2556
|Abstract »|Full Text »|PDF »
Selective estrogen receptor-{alpha} and estrogen receptor-{beta} agonists rapidly decrease pulmonary artery vasoconstriction by a nitric oxide-dependent mechanism.
T. Lahm, P. R. Crisostomo, T. A. Markel, M. Wang, Y. Wang, J. Tan, and D. R. Meldrum (2008)
Am J Physiol Regulatory Integrative Comp Physiol
295, R1486-R1493
|Abstract »|Full Text »|PDF »
Estrogen Receptor-{alpha} and Endothelial Nitric Oxide Synthase Nuclear Complex Regulates Transcription of Human Telomerase.
A. Grasselli, S. Nanni, C. Colussi, A. Aiello, V. Benvenuti, G. Ragone, F. Moretti, A. Sacchi, S. Bacchetti, C. Gaetano, et al. (2008)
Circ. Res.
103, 34-42
|Abstract »|Full Text »|PDF »
Estrogen Inhibits Cardiac Hypertrophy: Role of Estrogen Receptor-{beta} to Inhibit Calcineurin.
A. Pedram, M. Razandi, D. Lubahn, J. Liu, M. Vannan, and E. R. Levin (2008)
Endocrinology
149, 3361-3369
|Abstract »|Full Text »|PDF »
Newly Appreciated Pathophysiology of Ischemic Heart Disease in Women Mandates Changes in Perioperative Management: A Core Review.
Sex Steroids and Renal Disease: Lessons From Animal Studies.
L. L. Yanes, J. C. Sartori-Valinotti, and J. F. Reckelhoff (2008)
Hypertension
51, 976-981
|Full Text »|PDF »
Kidney in Hypertension: Guyton Redux.
T. M. Coffman and S. D. Crowley (2008)
Hypertension
51, 811-816
|Full Text »|PDF »
Wine Polyphenols Improve Endothelial Function in Large Vessels of Female Spontaneously Hypertensive Rats.
R. Lopez-Sepulveda, R. Jimenez, M. Romero, M. J. Zarzuelo, M. Sanchez, M. Gomez-Guzman, F. Vargas, F. O'Valle, A. Zarzuelo, F. Perez-Vizcaino, et al. (2008)
Hypertension
51, 1088-1095
|Abstract »|Full Text »|PDF »
Ligand-dependent activation of ER{beta} lowers blood pressure and attenuates cardiac hypertrophy in ovariectomized spontaneously hypertensive rats.
V. Jazbutyte, P. A. Arias-Loza, K. Hu, J. Widder, V. Govindaraj, C. von Poser-Klein, J. Bauersachs, K.-H. Fritzemeier, C. Hegele-Hartung, L. Neyses, et al. (2008)
Cardiovasc Res
77, 774-781
|Abstract »|Full Text »|PDF »
27-Hydroxycholesterol Is an Endogenous Selective Estrogen Receptor Modulator.
C. D. DuSell, M. Umetani, P. W. Shaul, D. J. Mangelsdorf, and D. P. McDonnell (2008)
Mol. Endocrinol.
22, 65-77
|Abstract »|Full Text »|PDF »
Functional characterization and sex differences in small mesenteric arteries of the estrogen receptor- knockout mouse.
G. Douglas, M. Natalia Cruz, L. Poston, J.-A. Gustafsson, and K. Kublickiene (2008)
Am J Physiol Regulatory Integrative Comp Physiol
294, R112-R120
|Abstract »|Full Text »|PDF »
The neurovascular dysfunction induced by angiotensin II in the mouse neocortex is sexually dimorphic.
H. Girouard, A. Lessard, C. Capone, T. A. Milner, and C. Iadecola (2008)
Am J Physiol Heart Circ Physiol
294, H156-H163
|Abstract »|Full Text »|PDF »
Polymorphisms and Haplotypes of the Estrogen Receptor-{beta} Gene (ESR2) and Cardiovascular Disease in Men and Women.
K. M. Rexrode, P. M. Ridker, H. H. Hegener, J. E. Buring, J. E. Manson, and R. Y.L. Zee (2007)
Clin. Chem.
53, 1749-1756
|Abstract »|Full Text »|PDF »
Contribution of epoxyeicosatrienoic acids to flow-induced dilation in arteries of male ER{alpha} knockout mice: role of aromatase.
D. Sun, C. Yan, A. Jacobson, H. Jiang, M. A. Carroll, and A. Huang (2007)
Am J Physiol Regulatory Integrative Comp Physiol
293, R1239-R1246
|Abstract »|Full Text »|PDF »
Both Estrogen Receptor Subtypes, {alpha} and {beta}, Attenuate Cardiovascular Remodeling in Aldosterone Salt-Treated Rats.
P.-A. Arias-Loza, K. Hu, C. Dienesch, A. M. Mehlich, S. Konig, V. Jazbutyte, L. Neyses, C. Hegele-Hartung, K. Heinrich Fritzemeier, and T. Pelzer (2007)
Hypertension
50, 432-438
|Abstract »|Full Text »|PDF »
Loss-of-Function Deletion of the Steroid Receptor Coactivator-1 Gene in Mice Reduces Estrogen Effect on the Vascular Injury Response.
Estrogen Receptors {alpha} and {beta} Mediate Distinct Pathways of Vascular Gene Expression, Including Genes Involved in Mitochondrial Electron Transport and Generation of Reactive Oxygen Species.
R. O'Lone, K. Knorr, I. Z. Jaffe, M. E. Schaffer, P. G. V. Martini, R. H. Karas, J. Bienkowska, M. E. Mendelsohn, and U. Hansen (2007)
Mol. Endocrinol.
21, 1281-1296
|Abstract »|Full Text »|PDF »
Estrogen receptor-{alpha} mediates estrogen protection from angiotensin II-induced hypertension in conscious female mice.
B. Xue, J. Pamidimukkala, D. B. Lubahn, and M. Hay (2007)
Am J Physiol Heart Circ Physiol
292, H1770-H1776
|Abstract »|Full Text »|PDF »
Compromised Aortic Vasoreactivity in Male Estrogen Receptor-{alpha}-Deficient Mice during Acute Lipopolysaccharide-Induced Inflammation.
A. M. Corbacho, J. P. Eiserich, L. A. Zuniga, G. Valacchi, and A. C. Villablanca (2007)
Endocrinology
148, 1403-1411
|Abstract »|Full Text »|PDF »
Role of Renal Angiotensin II Type 1 Receptors in the Genesis of Hypertension: Guyton Revisited: Angiotensin II Causes Hypertension and Cardiac Hypertrophy through Its Receptors in the Kidney. Proc Natl Acad Sci U S A 103: 17985-17990, 2006.
S.D. Crowley, S.B. Gurley, M.J. Herrera, P. Ruiz, R. Griffiths, A.P. Kumar, H.-S. Kim, O. Smithies, T.H. Le, T.M. Coffman, et al. (2007)
J. Am. Soc. Nephrol.
18, 356-363
|Full Text »|PDF »
Mitochondria play an important role in 17beta-estradiol attenuation of H2O2-induced rat endothelial cell apoptosis.
A. Lu, M. Frink, M. A. Choudhry, W. J. Hubbard, L. W. Rue III, K. I. Bland, and I. H. Chaudry (2007)
Am J Physiol Endocrinol Metab
292, E585-E593
|Abstract »|Full Text »|PDF »
Estrogen Receptor-{beta}: Recent Lessons from in Vivo Studies.
17beta-Estradiol modulates vasoconstriction induced by endothelin-1 following trauma-hemorrhage.
Z. F. Ba, A. Lu, T. Shimizu, L. Szalay, M. G. Schwacha, L. W. Rue III, K. I. Bland, and I. H. Chaudry (2007)
Am J Physiol Heart Circ Physiol
292, H245-H250
|Abstract »|Full Text »|PDF »
The oestrogen receptor {beta} contributes to sex related differences in endothelial function of murine small arteries via EDHF.
L. Luksha, L. Poston, J.-A. Gustafsson, K. Hultenby, and K. Kublickiene (2006)
J. Physiol.
577, 945-955
|Abstract »|Full Text »|PDF »
International Union of Pharmacology. LXIV. Estrogen Receptors.
K. Dahlman-Wright, V. Cavailles, S. A. Fuqua, V. C. Jordan, J. A. Katzenellenbogen, K. S. Korach, A. Maggi, M. Muramatsu, M. G. Parker, and J.-A. Gustafsson (2006)
Pharmacol. Rev.
58, 773-781
|Full Text »|PDF »
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.
S. D. Crowley, S. B. Gurley, M. J. Herrera, P. Ruiz, R. Griffiths, A. P. Kumar, H.-S. Kim, O. Smithies, T. H. Le, and T. M. Coffman (2006)
PNAS
103, 17985-17990
|Abstract »|Full Text »|PDF »
Medroxyprogesterone Acetate But Not Drospirenone Ablates the Protective Function of 17{beta}-Estradiol in Aldosterone Salt-Treated Rats.
P. A. Arias-Loza, K. Hu, A. Schafer, J. Bauersachs, T. Quaschning, J. Galle, V. Jazbutyte, L. Neyses, G. Ertl, K.-H. Fritzemeier, et al. (2006)
Hypertension
48, 994-1001
|Abstract »|Full Text »|PDF »
Selective Agonists of Estrogen Receptor Isoforms: New Perspectives for Cardiovascular Disease.
C. Bolego, E. Vegeto, C. Pinna, A. Maggi, and A. Cignarella (2006)
Arterioscler Thromb Vasc Biol
26, 2192-2199
|Abstract »|Full Text »|PDF »
Intimal Estrogen Receptor (ER){beta}, But Not ER{alpha} Expression, Is Correlated with Coronary Calcification and Atherosclerosis in Pre- and Postmenopausal Women.
R. C. Christian, P. Y. Liu, S. Harrington, M. Ruan, V. M. Miller, and L. A. Fitzpatrick (2006)
J. Clin. Endocrinol. Metab.
91, 2713-2720
|Abstract »|Full Text »|PDF »
Gender Differences of Cardiovascular Disease: New Perspectives for Estrogen Receptor Signaling.
M. R. Meyer, E. Haas, and M. Barton (2006)
Hypertension
47, 1019-1026
|Full Text »|PDF »
A. Morani, R. P. A. Barros, O. Imamov, K. Hultenby, A. Arner, M. Warner, and J.-A. Gustafsson (2006)
PNAS
103, 7165-7169
|Abstract »|Full Text »|PDF »
Acute responses to phytoestrogens in small arteries from men with coronary heart disease.
M. N. Cruz, L. Luksha, H. Logman, L. Poston, S. Agewall, and K. Kublickiene (2006)
Am J Physiol Heart Circ Physiol
290, H1969-H1975
|Abstract »|Full Text »|PDF »
Metabolite ligands of estrogen receptor-{beta} reduce primate coronary hyperreactivity.
R. G. Mishra, F. Z. Stanczyk, K. A. Burry, S. Oparil, B. S. Katzenellenbogen, M. L. Nealen, J. A. Katzenellenbogen, and R. K. Hermsmeyer (2006)
Am J Physiol Heart Circ Physiol
290, H295-H303
|Abstract »|Full Text »|PDF »
Protective Effect of the KCNMB1 E65K Genetic Polymorphism Against Diastolic Hypertension in Aging Women and Its Relevance to Cardiovascular Risk.
M. Senti, J. M. Fernandez-Fernandez, M. Tomas, E. Vazquez, R. Elosua, J. Marrugat, and M. A. Valverde (2005)
Circ. Res.
97, 1360-1365
|Abstract »|Full Text »|PDF »
Association of Estrogen Receptor {beta} Gene Polymorphisms With Left Ventricular Mass and Wall Thickness in Women.
I. Peter, A. M. Shearman, R. S. Vasan, D. R. Zucker, C. H. Schmid, S. Demissie, L. A. Cupples, J. T. Kuvin, R. H. Karas, M. E. Mendelsohn, et al. (2005)
Am J Hypertens
18, 1388-1395
|Abstract »|Full Text »|PDF »
Small Artery Endothelial Dysfunction in Postmenopausal Women: In Vitro Function, Morphology, and Modification by Estrogen and Selective Estrogen Receptor Modulators.
K. Kublickiene, E. Svedas, B.-M. Landgren, M. Crisby, N. Nahar, H. Nisell, and L. Poston (2005)
J. Clin. Endocrinol. Metab.
90, 6113-6122
|Abstract »|Full Text »|PDF »
Gender-Specific Alteration of Adrenergic Responses in Small Femoral Arteries From Estrogen Receptor-{beta} Knockout Mice.
L. Luksha, L. Poston, J.-A. Gustafsson, L. Aghajanova, and K. Kublickiene (2005)
Hypertension
46, 1163-1168
|Abstract »|Full Text »|PDF »
Sex Hormones as Potential Modulators of Vascular Function in Hypertension.
Increased Mortality and Aggravation of Heart Failure in Estrogen Receptor-{beta} Knockout Mice After Myocardial Infarction.
T. Pelzer, P.-A. A. Loza, K. Hu, B. Bayer, C. Dienesch, L. Calvillo, J. F. Couse, K. S. Korach, L. Neyses, and G. Ertl (2005)
Circulation
111, 1492-1498
|Abstract »|Full Text »|PDF »
Recommendations for Blood Pressure Measurement in Humans and Experimental Animals: Part 2: Blood Pressure Measurement in Experimental Animals. A Statement for Professionals From the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research.
T. W. Kurtz, K. A. Griffin, A. K. Bidani, R. L. Davisson, and J. E. Hall (2005)
Arterioscler Thromb Vasc Biol
25, e22-e33
|Abstract »|Full Text »|PDF »
Estrogen receptor-{alpha} mediates estrogen facilitation of baroreflex heart rate responses in conscious mice.
J. Pamidimukkala, B. Xue, L. G. Newton, D. B. Lubahn, and M. Hay (2005)
Am J Physiol Heart Circ Physiol
288, H1063-H1070
|Abstract »|Full Text »|PDF »
Investigation of Vascular Responses in Endothelial Nitric Oxide Synthase/Cyclooxygenase-1 Double-Knockout Mice: Key Role for Endothelium-Derived Hyperpolarizing Factor in the Regulation of Blood Pressure in Vivo.
R. S. Scotland, M. Madhani, S. Chauhan, S. Moncada, J. Andresen, H. Nilsson, A. J. Hobbs, and A. Ahluwalia (2005)
Circulation
111, 796-803
|Abstract »|Full Text »|PDF »
Estrogen receptor-{beta} mediates male-female differences in the development of pressure overload hypertrophy.
M. Skavdahl, C. Steenbergen, J. Clark, P. Myers, T. Demianenko, L. Mao, H. A. Rockman, K. S. Korach, and E. Murphy (2005)
Am J Physiol Heart Circ Physiol
288, H469-H476
|Abstract »|Full Text »|PDF »
Recommendations for Blood Pressure Measurement in Humans and Experimental Animals: Part 2: Blood Pressure Measurement in Experimental Animals: A Statement for Professionals From the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research.
T. W. Kurtz, K. A. Griffin, A. K. Bidani, R. L. Davisson, and J. E. Hall (2005)
Hypertension
45, 299-310
|Abstract »|Full Text »|PDF »
Estrogen Receptor-{alpha} Agonists Promote Angiogenesis in Human Myometrial Microvascular Endothelial Cells.
M. Zaitseva, D. S. Yue, J. A. Katzenellenbogen, P. A. W. Rogers, and C. E. Gargett (2004)
Reproductive Sciences
11, 529-535
|Abstract »|PDF »
Characterization of the ER{beta}-/-mouse heart.
C. Forster, S. Kietz, K. Hultenby, M. Warner, and J.-A. Gustafsson (2004)
PNAS
101, 14234-14239
|Abstract »|Full Text »|PDF »
Evidence for the Notch Signaling Pathway on the Role of Estrogen in Angiogenesis.
R. Soares, G. Balogh, S. Guo, F. Gartner, J. Russo, and F. Schmitt (2004)
Mol. Endocrinol.
18, 2333-2343
|Abstract »|Full Text »|PDF »
Aromatase-Deficient (ArKO) Mice Have Reduced Blood Pressure and Baroreflex Sensitivity.
G. A. Head, V. R. Obeyesekere, M. E. Jones, E. R. Simpson, and Z. S. Krozowski (2004)
Endocrinology
145, 4286-4291
|Abstract »|Full Text »|PDF »
A. S. Lovegrove, J. Sun, K. A. Gould, D. B. Lubahn, K. S. Korach, and P. H. Lane (2004)
Am J Physiol Renal Physiol
287, F586-F591
|Abstract »|Full Text »|PDF »
Gender modulates cardiac phenotype development in genetically modified mice.
A New Slice of Pie?: Estrogen Regulation of Plasminogen Activator Inhibitor-1.
N. Madamanchi, X. Liu, and M. S. Runge (2004)
Circ. Res.
95, 228-229
|Full Text »|PDF »
Endothelium-Dependent and Independent Enhancement of Vascular Contractility in the Ovariectomized Rabbit.
M. Koga, K. Hirano, J. Nishimura, H. Nakano, and H. Kanaide (2004)
Reproductive Sciences
11, 272-279
|Abstract »|PDF »
The G Protein-coupled Receptor GPR30 Mediates c-fos Up-regulation by 17{beta}-Estradiol and Phytoestrogens in Breast Cancer Cells.
M. Maggiolini, A. Vivacqua, G. Fasanella, A. G. Recchia, D. Sisci, V. Pezzi, D. Montanaro, A. M. Musti, D. Picard, and S. Ando (2004)
J. Biol. Chem.
279, 27008-27016
|Abstract »|Full Text »|PDF »
Differential Regulation of Estrogen Receptor Subtypes {alpha} and {beta} in Human Aortic Smooth Muscle Cells by Oligonucleotides and Estradiol.
F. Barchiesi, E. K. Jackson, B. Imthurn, J. Fingerle, D. G. Gillespie, and R. K. Dubey (2004)
J. Clin. Endocrinol. Metab.
89, 2373-2381
|Abstract »|Full Text »|PDF »
Aberrant Cholesterol Transport and Impaired Steroidogenesis in Leydig Cells Lacking Estrogen Sulfotransferase.
M. H. Tong, L. K. Christenson, and W.-C. Song (2004)
Endocrinology
145, 2487-2497
|Abstract »|Full Text »|PDF »
Gender, sex hormones, and vascular tone.
J. M. Orshal and R. A. Khalil (2004)
Am J Physiol Regulatory Integrative Comp Physiol
286, R233-R249
|Abstract »|Full Text »|PDF »
Hormonal Regulation of Normal Vascular Tone in Males.
M. E. Mendelsohn and G. M.C. Rosano (2003)
Circ. Res.
93, 1142-1145
|Full Text »|PDF »
Impaired Acetylcholine-Induced Release of Nitric Oxide in the Aorta of Male Aromatase-Knockout Mice: Regulation of Nitric Oxide Production by Endogenous Sex Hormones in Males.
M. Kimura, K. Sudhir, M. Jones, E. Simpson, A.-M. Jefferis, and J. P.F. Chin-Dusting (2003)
Circ. Res.
93, 1267-1271
|Abstract »|Full Text »|PDF »
Regulation of nitric oxide-dependent vasodilation in coronary arteries of estrogen receptor-{alpha}-deficient mice.
J. M. Muller-Delp, D. B. Lubahn, K. E. Nichol, B. J. Philips, E. M. Price, E. M. Curran, and M. H. Laughlin (2003)
Am J Physiol Heart Circ Physiol
285, H2150-H2157
|Abstract »|Full Text »|PDF »
(ER
