Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Helicobacter pylori CagA protein is
associated with severe gastritis and gastric carcinoma. CagA is
injected from the attachedHelicobacter pylori into host
cells and undergoes tyrosine phosphorylation.Wild-type but
not phosphorylation-resistant CagA induced a growthfactor-like response in gastric epithelial cells. Furthermore,CagA
formed a physical complex with the SRC homology 2 domain(SH2)-containing tyrosine phosphatase SHP-2 in a
phosphorylation-dependentmanner and stimulated the
phosphatase activity. Disruption ofthe CagA-SHP-2 complex
abolished the CagA-dependent cellular response.Conversely, the CagA
effect on cells was reproduced by constitutivelyactive SHP-2. Thus,
upon translocation, CagA perturbs cellularfunctions by deregulating
SHP-2.
1 Division of Molecular Oncology, Institute for
Genetic Medicine and Graduate School of Science, Hokkaido University,
Sapporo 060-0815, Japan.
2 Department of
Gastroenterology & Hematology, Graduate School of Medicine, Hokkaido
University, Sapporo 060-0815, Japan.
3 The Second
Department of Internal Medicine, Fukui Medical University, Fukui
910-1193, Japan.
*
To whom correspondence should be addressed. E-mail:
mhata{at}imm.hokudai.ac.jp
The editors suggest the following Related Resources on Science sites:
H. pylori virulence factor CagA increases intestinal cell proliferation by Wnt pathway activation in a transgenic zebrafish model.
J. T. Neal, T. S. Peterson, M. L. Kent, and K. Guillemin (2013)
Dis. Model. Mech.
6, 802-810
|Abstract »|Full Text »|PDF »
Shp2 Plays an Important Role in Acute Cigarette Smoke-Mediated Lung Inflammation.
F.-f. Li, J. Shen, H.-j. Shen, X. Zhang, R. Cao, Y. Zhang, Q. Qui, X.-x. Lin, Y.-c. Xie, L.-h. Zhang, et al. (2012)
J. Immunol.
189, 3159-3167
|Abstract »|Full Text »|PDF »
Helicobacter pylori CagL dependent induction of gastrin expression via a novel {alpha}v{beta}5-integrin-integrin linked kinase signalling complex.
T. Wiedemann, S. Hofbaur, N. Tegtmeyer, S. Huber, N. Sewald, S. Wessler, S. Backert, and G. Rieder (2012)
Gut
61, 986-996
|Abstract »|Full Text »|PDF »
J-Western Forms of Helicobacter pylori cagA Constitute a Distinct Phylogenetic Group with a Widespread Geographic Distribution.
S. S. Duncan, P. L. Valk, C. L. Shaffer, S. R. Bordenstein, and T. L. Cover (2012)
J. Bacteriol.
194, 1593-1604
|Abstract »|Full Text »|PDF »
Y. Yamahashi, Y. Saito, N. Murata-Kamiya, and M. Hatakeyama (2011)
J. Biol. Chem.
286, 44576-44584
|Abstract »|Full Text »|PDF »
Potentiation of Helicobacter pylori CagA Protein Virulence through Homodimerization.
L. Nagase, N. Murata-Kamiya, and M. Hatakeyama (2011)
J. Biol. Chem.
286, 33622-33631
|Abstract »|Full Text »|PDF »
Helicobacter pylori homB, but Not cagA, Is Associated with Gastric Cancer in Iran.
A. Talebi Bezmin Abadi, A. Rafiei, A. Ajami, V. Hosseini, T. Taghvaei, K. R. Jones, and D. S. Merrell (2011)
J. Clin. Microbiol.
49, 3191-3197
|Abstract »|Full Text »|PDF »
Attenuated CagA Oncoprotein in Helicobacter pylori from Amerindians in Peruvian Amazon.
M. Suzuki, K. Kiga, D. Kersulyte, J. Cok, C. C. Hooper, H. Mimuro, T. Sanada, S. Suzuki, M. Oyama, H. Kozuka-Hata, et al. (2011)
J. Biol. Chem.
286, 29964-29972
|Abstract »|Full Text »|PDF »
Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host.
L. Buti, E. Spooner, A. G. Van der Veen, R. Rappuoli, A. Covacci, and H. L. Ploegh (2011)
PNAS
108, 9238-9243
|Abstract »|Full Text »|PDF »
Species-Specific Interactions of Src Family Tyrosine Kinases Regulate Chlamydia Intracellular Growth and Trafficking.
Long-term proton pump inhibitor administration worsens atrophic corpus gastritis and promotes adenocarcinoma development in Mongolian gerbils infected with Helicobacter pylori.
T. Hagiwara, K.-i. Mukaisho, T. Nakayama, H. Sugihara, and T. Hattori (2011)
Gut
60, 624-630
|Abstract »|Full Text »|PDF »
A Novel Inhibitory Domain of Helicobacter pylori Protein CagA Reduces CagA Effects on Host Cell Biology.
C. Pelz, S. Steininger, C. Weiss, F. Coscia, and R. Vogelmann (2011)
J. Biol. Chem.
286, 8999-9008
|Abstract »|Full Text »|PDF »
Change Is Good: Variations in Common Biological Mechanisms in the Epsilonproteobacterial Genera Campylobacter and Helicobacter.
J. J. Gilbreath, W. L. Cody, D. S. Merrell, and D. R. Hendrixson (2011)
Microbiol. Mol. Biol. Rev.
75, 84-132
|Abstract »|Full Text »|PDF »
Polymorphisms in the Intermediate Region of VacA Impact Helicobacter pylori-Induced Disease Development.
K. R. Jones, S. Jang, J. Y. Chang, J. Kim, I.-S. Chung, C. H. Olsen, D. S. Merrell, and J.-H. Cha (2011)
J. Clin. Microbiol.
49, 101-110
|Abstract »|Full Text »|PDF »
Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk.
L. E. Wroblewski, R. M. Peek Jr., and K. T. Wilson (2010)
Clin. Microbiol. Rev.
23, 713-739
|Abstract »|Full Text »|PDF »
Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21.
Y. Saito, N. Murata-Kamiya, T. Hirayama, Y. Ohba, and M. Hatakeyama (2010)
J. Exp. Med.
207, 2157-2174
|Abstract »|Full Text »|PDF »
Helicobacter pylori CagA inhibits endocytosis of cytotoxin VacA in host cells.
J. K. Akada, H. Aoki, Y. Torigoe, T. Kitagawa, H. Kurazono, H. Hoshida, J. Nishikawa, S. Terai, M. Matsuzaki, T. Hirayama, et al. (2010)
Dis. Model. Mech.
3, 605-617
|Abstract »|Full Text »|PDF »
Translocation of Helicobacter pylori CagA into Human B Lymphocytes, the Origin of Mucosa-Associated Lymphoid Tissue Lymphoma.
W.-C. Lin, H.-F. Tsai, S.-H. Kuo, M.-S. Wu, C.-W. Lin, P.-I. Hsu, A.-L. Cheng, and P.-N. Hsu (2010)
Cancer Res.
70, 5740-5748
|Abstract »|Full Text »|PDF »
Helicobacter pylori represses proton pump expression and inhibits acid secretion in human gastric mucosa.
A. Saha, C. E. Hammond, C. Beeson, R. M. Peek Jr, and A. J. Smolka (2010)
Gut
59, 874-881
|Abstract »|Full Text »|PDF »
Helicobacter pylori CagA Phosphorylation Status Determines the gp130-activated SHP2/ERK and JAK/STAT Signal Transduction Pathways in Gastric Epithelial Cells.
I. O. Lee, J. H. Kim, Y. J. Choi, M. H. Pillinger, S. Y. Kim, M. J. Blaser, and Y. C. Lee (2010)
J. Biol. Chem.
285, 16042-16050
|Abstract »|Full Text »|PDF »
Epidemiological Link between Gastric Disease and Polymorphisms in VacA and CagA.
S. Jang, K. R. Jones, C. H. Olsen, Y. M. Joo, Y.-J. Yoo, I.-S. Chung, J.-H. Cha, and D. S. Merrell (2010)
J. Clin. Microbiol.
48, 559-567
|Abstract »|Full Text »|PDF »
Diverse Characteristics of the cagA Gene of Helicobacter pylori Strains Collected from Patients from Southern Vietnam with Gastric Cancer and Peptic Ulcer.
B. X. Truong, V. T. C. Mai, H. Tanaka, L. T. Ly, T. M. Thong, H. H. Hai, D. Van Long, K. Furumatsu, M. Yoshida, H. Kutsumi, et al. (2009)
J. Clin. Microbiol.
47, 4021-4028
|Abstract »|Full Text »|PDF »
Evaluation of the Anti-East Asian CagA-Specific Antibody for CagA Phenotyping.
L. T. Nguyen, T. Uchida, A. Kuroda, Y. Tsukamoto, T. D. Trinh, L. Ta, H. B. Mai, D. Q. D. Ho, H. H. Hoang, R.-K. Vilaichone, et al. (2009)
Clin. Vaccine Immunol.
16, 1687-1692
|Abstract »|Full Text »|PDF »
Assessment of East Asian-type cagA-positive Helicobacter pylori using stool specimens from asymptomatic healthy Japanese individuals.
I. Hirai, T. Sasaki, A. Kimoto, S. Fujimoto, T. Moriyama, and Y. Yamamoto (2009)
J. Med. Microbiol.
58, 1149-1153
|Abstract »|Full Text »|PDF »
Role of Partitioning-defective 1/Microtubule Affinity-regulating Kinases in the Morphogenetic Activity of Helicobacter pylori CagA.
H. Lu, N. Murata-Kamiya, Y. Saito, and M. Hatakeyama (2009)
J. Biol. Chem.
284, 23024-23036
|Abstract »|Full Text »|PDF »
Helicobacter pylori CagA Causes Mitotic Impairment and Induces Chromosomal Instability.
M. Umeda, N. Murata-Kamiya, Y. Saito, Y. Ohba, M. Takahashi, and M. Hatakeyama (2009)
J. Biol. Chem.
284, 22166-22172
|Abstract »|Full Text »|PDF »
CagA and VacA Polymorphisms Do Not Correlate with Severity of Histopathological Lesions in Helicobacter pylori-Infected Greek Children.
D. N. Sgouras, E. G. Panayotopoulou, K. Papadakos, B. Martinez-Gonzalez, A. Roumbani, J. Panayiotou, C. vanVliet-Constantinidou, A. F. Mentis, and E. Roma-Giannikou (2009)
J. Clin. Microbiol.
47, 2426-2434
|Abstract »|Full Text »|PDF »
Delineation of a Carcinogenic Helicobacter pylori Proteome.
A. T. Franco, D. B. Friedman, T. A. Nagy, J. Romero-Gallo, U. Krishna, A. Kendall, D. A. Israel, N. Tegtmeyer, M. K. Washington, and R. M. Peek Jr. (2009)
Mol. Cell. Proteomics
8, 1947-1958
|Abstract »|Full Text »|PDF »
Reduced Expression of CD45 Protein-tyrosine Phosphatase Provides Protection against Anthrax Pathogenesis.
R. G. Panchal, R. L. Ulrich, S. B. Bradfute, D. Lane, G. Ruthel, T. A. Kenny, P. L. Iversen, A. O. Anderson, R. Gussio, W. C. Raschke, et al. (2009)
J. Biol. Chem.
284, 12874-12885
|Abstract »|Full Text »|PDF »
Roles of gastric mucin-type O-glycans in the pathogenesis of Helicobacter pylori infection.
M. Kobayashi, H. Lee, J. Nakayama, and M. Fukuda (2009)
Glycobiology
19, 453-461
|Abstract »|Full Text »|PDF »
Polymorphism in the CagA EPIYA Motif Impacts Development of Gastric Cancer.
K. R. Jones, Y. M. Joo, S. Jang, Y.-J. Yoo, H. S. Lee, I.-S. Chung, C. H. Olsen, J. M. Whitmire, D. S. Merrell, and J.-H. Cha (2009)
J. Clin. Microbiol.
47, 959-968
|Abstract »|Full Text »|PDF »
Helicobacter pylori virulence and the diversity of gastric cancer in Asia.
L. T. Nguyen, T. Uchida, K. Murakami, T. Fujioka, and M. Moriyama (2008)
J. Med. Microbiol.
57, 1445-1453
|Abstract »|Full Text »|PDF »
Regulation of ROS signal transduction by NADPH oxidase 4 localization.
K. Chen, M. T. Kirber, H. Xiao, Y. Yang, and J. F. Keaney Jr. (2008)
J. Cell Biol.
181, 1129-1139
|Abstract »|Full Text »|PDF »
p120 and Kaiso Regulate Helicobacter pylori-induced Expression of Matrix Metalloproteinase-7.
S. R. Ogden, L. E. Wroblewski, C. Weydig, J. Romero-Gallo, D. P. O'Brien, D. A. Israel, U. S. Krishna, B. Fingleton, A. B. Reynolds, S. Wessler, et al. (2008)
Mol. Biol. Cell
19, 4110-4121
|Abstract »|Full Text »|PDF »
Helicobacter pylori Infection Stimulates Plasminogen Activator Inhibitor 1 Production by Gastric Epithelial Cells.
A. C. Keates, S. Tummala, R. M. Peek Jr., E. Csizmadia, B. Kunzli, K. Becker, P. Correa, J. Romero-Gallo, M. B. Piazuelo, S. Sheth, et al. (2008)
Infect. Immun.
76, 3992-3999
|Abstract »|Full Text »|PDF »
Regulation of the Helicobacter pylori Cellular Receptor Decay-accelerating Factor.
D. P. O'Brien, J. Romero-Gallo, B. G. Schneider, R. Chaturvedi, A. Delgado, E. J. Harris, U. Krishna, S. R. Ogden, D. A. Israel, K. T. Wilson, et al. (2008)
J. Biol. Chem.
283, 23922-23930
|Abstract »|Full Text »|PDF »
Prevention of gastric cancer: When is treatment of Helicobacter pylori warranted?.
R. M. Peek Jr (2008)
Therapeutic Advances in Gastroenterology
1, 19-31
|Abstract »|PDF »
The {beta}1 Integrin Activates JNK Independent of CagA, and JNK Activation Is Required for Helicobacter pylori CagA+-induced Motility of Gastric Cancer Cells.
J. L. Snider, C. Allison, B. H. Bellaire, R. L. Ferrero, and J. A. Cardelli (2008)
J. Biol. Chem.
283, 13952-13963
|Abstract »|Full Text »|PDF »
Toxigenic Helicobacter pylori Infection Precedes Gastric Hypochlorhydria in Cancer Relatives, and H. pylori Virulence Evolves in These Families.
R. H. Argent, R. J. Thomas, F. Aviles-Jimenez, D. P. Letley, M. C. Limb, E. M. El-Omar, and J. C. Atherton (2008)
Clin. Cancer Res.
14, 2227-2235
|Abstract »|Full Text »|PDF »
Functional association between the Helicobacter pylori virulence factors VacA and CagA.
R. H. Argent, R. J. Thomas, D. P. Letley, M. G. Rittig, K. R. Hardie, and J. C. Atherton (2008)
J. Med. Microbiol.
57, 145-150
|Abstract »|Full Text »|PDF »
Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse.
N. Ohnishi, H. Yuasa, S. Tanaka, H. Sawa, M. Miura, A. Matsui, H. Higashi, M. Musashi, K. Iwabuchi, M. Suzuki, et al. (2008)
PNAS
105, 1003-1008
|Abstract »|Full Text »|PDF »
Regulation of Gastric Carcinogenesis by Helicobacter pylori Virulence Factors.
A. T. Franco, E. Johnston, U. Krishna, Y. Yamaoka, D. A. Israel, T. A. Nagy, L. E. Wroblewski, M. B. Piazuelo, P. Correa, and R. M. Peek Jr. (2008)
Cancer Res.
68, 379-387
|Abstract »|Full Text »|PDF »
The Helicobacter pylori CagF protein is a type IV secretion chaperone-like molecule that binds close to the C-terminal secretion signal of the CagA effector protein.
I. Pattis, E. Weiss, R. Laugks, R. Haas, and W. Fischer (2007)
Microbiology
153, 2896-2909
|Abstract »|Full Text »|PDF »
Heterogeneity in the Activity of Mexican Helicobacter pylori Strains in Gastric Epithelial Cells and Its Association with Diversity in the cagA Gene.
A. Reyes-Leon, J. C. Atherton, R. H. Argent, J. L. Puente, and J. Torres (2007)
Infect. Immun.
75, 3445-3454
|Abstract »|Full Text »|PDF »
Helicobacter and gastrin stimulate Reg1 expression in gastric epithelial cells through distinct promoter elements.
I. A. Steele, R. Dimaline, D. M. Pritchard, R. M. Peek Jr., T. C. Wang, G. J. Dockray, and A. Varro (2007)
Am J Physiol Gastrointest Liver Physiol
293, G347-G354
|Abstract »|Full Text »|PDF »
Helicobacter pylori Stimulates Gastric Epithelial Cell MMP-1 Secretion via CagA-dependent and -independent ERK Activation.
M. H. Pillinger, N. Marjanovic, S.-Y. Kim, Y.-C. Lee, J. U. Scher, J. Roper, A. M. Abeles, P. I. Izmirly, M. Axelrod, M. Y. Pillinger, et al. (2007)
J. Biol. Chem.
282, 18722-18731
|Abstract »|Full Text »|PDF »
Helicobacter pylori CagA Induces AGS Cell Elongation through a Cell Retraction Defect That Is Independent of Cdc42, Rac1, and Arp2/3.
K. M. Bourzac, C. M. Botham, and K. Guillemin (2007)
Infect. Immun.
75, 1203-1213
|Abstract »|Full Text »|PDF »
Strategy To Characterize the Number and Type of Repeating EPIYA Phosphorylation Motifs in the Carboxyl Terminus of CagA Protein in Helicobacter pylori Clinical Isolates.
E. G. Panayotopoulou, D. N. Sgouras, K. Papadakos, A. Kalliaropoulos, G. Papatheodoridis, A. F. Mentis, and A. J. Archimandritis (2007)
J. Clin. Microbiol.
45, 488-495
|Abstract »|Full Text »|PDF »
Helicobacter pylori Induces Gastric Epithelial Cell Invasion in a c-Met and Type IV Secretion System-dependent Manner.
M. J. Oliveira, A. C. Costa, A. M. Costa, L. Henriques, G. Suriano, J. C. Atherton, J. C. Machado, F. Carneiro, R. Seruca, M. Mareel, et al. (2006)
J. Biol. Chem.
281, 34888-34896
|Abstract »|Full Text »|PDF »
Structural Basis and Functional Consequence of Helicobacter pylori CagA Multimerization in Cells.
S. Ren, H. Higashi, H. Lu, T. Azuma, and M. Hatakeyama (2006)
J. Biol. Chem.
281, 32344-32352
|Abstract »|Full Text »|PDF »
Human Milk Vacuolating Cytotoxin A Immunoglobulin A Antibodies Modify Helicobacter pylori Infection in Gambian Children.
D. I. Campbell, J. E. G. Bunn, L. T. Weaver, M. Harding, W. A. Coward, and J. E. Thomas (2006)
Clinical Infectious Diseases
43, 1040-1042
|Abstract »|Full Text »|PDF »
Helicobacter pylori Persistence: an Overview of Interactions between H. pylori and Host Immune Defenses.
Antagonism or Synergism: ROLE OF TYROSINE PHOSPHATASES SHP-1 AND SHP-2 IN GROWTH FACTOR SIGNALING.
N. Wang, Z. Li, R. Ding, G. D. Frank, T. Senbonmatsu, E. J. Landon, T. Inagami, and Z. J. Zhao (2006)
J. Biol. Chem.
281, 21878-21883
|Abstract »|Full Text »|PDF »
Pathogenesis of Helicobacter pylori Infection.
J. G. Kusters, A. H. M. van Vliet, and E. J. Kuipers (2006)
Clin. Microbiol. Rev.
19, 449-490
|Abstract »|Full Text »|PDF »
Protein-Protein Interactions among Helicobacter pylori Cag Proteins.
V. J. Busler, V. J. Torres, M. S. McClain, O. Tirado, D. B. Friedman, and T. L. Cover (2006)
J. Bacteriol.
188, 4787-4800
|Abstract »|Full Text »|PDF »
Helicobacter pylori-associated oxidant monochloramine induces reactivation of Epstein-Barr virus (EBV) in gastric epithelial cells latently infected with EBV..
J. Minoura-Etoh, K. Gotoh, R. Sato, M. Ogata, N. Kaku, T. Fujioka, and A. Nishizono (2006)
J. Med. Microbiol.
55, 905-911
|Abstract »|Full Text »|PDF »
Helicobacter pylori CagA-Dependent Macrophage Migration Inhibitory Factor Produced by Gastric Epithelial Cells Binds to CD74 and Stimulates Procarcinogenic Events..
E. J. Beswick, I. V. Pinchuk, G. Suarez, J. C. Sierra, and V. E. Reyes (2006)
J. Immunol.
176, 6794-6801
|Abstract »|Full Text »|PDF »
The Role of Decay-accelerating Factor as a Receptor for Helicobacter pylori and a Mediator of Gastric Inflammation.
D. P. O'Brien, D. A. Israel, U. Krishna, J. Romero-Gallo, J. Nedrud, M. E. Medof, F. Lin, R. Redline, D. M. Lublin, B. J. Nowicki, et al. (2006)
J. Biol. Chem.
281, 13317-13323
|Abstract »|Full Text »|PDF »
Host-Mediated Phosphorylation of Type III Effector AvrPto Promotes Pseudomonas Virulence and Avirulence in Tomato.
J. C. Anderson, P. E. Pascuzzi, F. Xiao, G. Sessa, and G. B. Martin (2006)
PLANT CELL
18, 502-514
|Abstract »|Full Text »|PDF »
Focal Adhesion Kinase Is a Substrate and Downstream Effector of SHP-2 Complexed with Helicobacter pylori CagA.
R. Tsutsumi, A. Takahashi, T. Azuma, H. Higashi, and M. Hatakeyama (2006)
Mol. Cell. Biol.
26, 261-276
|Abstract »|Full Text »|PDF »
Helicobacter pylori Activates Myosin Light-Chain Kinase To Disrupt Claudin-4 and Claudin-5 and Increase Epithelial Permeability.
J. P. Fedwick, T. K. Lapointe, J. B. Meddings, P. M. Sherman, and A. G. Buret (2005)
Infect. Immun.
73, 7844-7852
|Abstract »|Full Text »|PDF »
Intrabacterial proton-dependent CagA transport system in Helicobacter pylori.
H. Wu, T. Nakano, E. Daikoku, C. Morita, T. Kohno, H. H Lian, and K. Sano (2005)
J. Med. Microbiol.
54, 1117-1125
|Abstract »|Full Text »|PDF »
Helicobacter pylori CagA induces a transition from polarized to invasive phenotypes in MDCK cells.
F. Bagnoli, L. Buti, L. Tompkins, A. Covacci, and M. R. Amieva (2005)
PNAS
102, 16339-16344
|Abstract »|Full Text »|PDF »
Interaction of CagA with Crk plays an important role in Helicobacter pylori-induced loss of gastric epithelial cell adhesion.
M. Suzuki, H. Mimuro, T. Suzuki, M. Park, T. Yamamoto, and C. Sasakawa (2005)
J. Exp. Med.
202, 1235-1247
|Abstract »|Full Text »|PDF »
Analysis of Cell Type-Specific Responses Mediated by the Type IV Secretion System of Helicobacter pylori.
B. Bauer, S. Moese, S. Bartfeld, T. F. Meyer, and M. Selbach (2005)
Infect. Immun.
73, 4643-4652
|Abstract »|Full Text »|PDF »
Comparison of Helicobacter pylori Virulence Gene Expression In Vitro and in the Rhesus Macaque.
J. K. Boonjakuakul, D. R. Canfield, and J. V. Solnick (2005)
Infect. Immun.
73, 4895-4904
|Abstract »|Full Text »|PDF »
Distinct Diversity of vacA, cagA, and cagE Genes of Helicobacter pylori Associated with Peptic Ulcer in Japan.
S. Yamazaki, A. Yamakawa, T. Okuda, M. Ohtani, H. Suto, Y. Ito, Y. Yamazaki, Y. Keida, H. Higashi, M. Hatakeyama, et al. (2005)
J. Clin. Microbiol.
43, 3906-3916
|Abstract »|Full Text »|PDF »
The Biology of Helicobacter pylori Infection, a Major Risk Factor for Gastric Adenocarcinoma.
D. Pinto-Santini and N. R. Salama (2005)
Cancer Epidemiol. Biomarkers Prev.
14, 1853-1858
|Abstract »|Full Text »|PDF »
Helicobacter pylori and Gastric Cancer: What can be Learned by Studying the Response of Gastric Epithelial Cells to the Infection?.
A. Mueller, S. Falkow, and M. R. Amieva (2005)
Cancer Epidemiol. Biomarkers Prev.
14, 1859-1864
|Abstract »|Full Text »|PDF »
Etiology of Gastric Cancer: What Is New?.
P. Correa and B. G. Schneider (2005)
Cancer Epidemiol. Biomarkers Prev.
14, 1865-1868
|Abstract »|Full Text »|PDF »
Helicobacter pylori infection in paediatric practice.
D I Campbell and J E Thomas (2005)
Arch. Dis. Child. Ed. Pract.
90, ep25-ep30
|Full Text »|PDF »
Activation of {beta}-catenin by carcinogenic Helicobacter pylori.
A. T. Franco, D. A. Israel, M. K. Washington, U. Krishna, J. G. Fox, A. B. Rogers, A. S. Neish, L. Collier-Hyams, G. I. Perez-Perez, M. Hatakeyama, et al. (2005)
PNAS
102, 10646-10651
|Abstract »|Full Text »|PDF »
Functional antagonism between Helicobacter pylori CagA and vacuolating toxin VacA in control of the NFAT signaling pathway in gastric epithelial cells.
K. Yokoyama, H. Higashi, S. Ishikawa, Y. Fujii, S. Kondo, H. Kato, T. Azuma, A. Wada, T. Hirayama, H. Aburatani, et al. (2005)
PNAS
102, 9661-9666
|Abstract »|Full Text »|PDF »
EPIYA Motif Is a Membrane-targeting Signal of Helicobacter pylori Virulence Factor CagA in Mammalian Cells.
H. Higashi, K. Yokoyama, Y. Fujii, S. Ren, H. Yuasa, I. Saadat, N. Murata-Kamiya, T. Azuma, and M. Hatakeyama (2005)
J. Biol. Chem.
280, 23130-23137
|Abstract »|Full Text »|PDF »
High Frequency of Gastric Colonization with Multiple Helicobacter pylori Strains in Venezuelan Subjects.
C. Ghose, G. I. Perez-Perez, L. J. van Doorn, M. G. Dominguez-Bello, and M. J. Blaser (2005)
J. Clin. Microbiol.
43, 2635-2641
|Abstract »|Full Text »|PDF »
Impact of Fasting Plasma Glucose Levels on Gastric Cancer Incidence in a General Japanese Population: The Hisayama Study.
H. Yamagata, Y. Kiyohara, S. Nakamura, M. Kubo, Y. Tanizaki, T. Matsumoto, K. Tanaka, I. Kato, T. Shirota, and M. Iida (2005)
Diabetes Care
28, 789-794
|Abstract »|Full Text »|PDF »
Orchestration of Aberrant Epithelial Signaling by Helicobacter pylori CagA.
Simple Method for Determination of the Number of Helicobacter pylori CagA Variable-Region EPIYA Tyrosine Phosphorylation Motifs by PCR.
R. H. Argent, Y. Zhang, and J. C. Atherton (2005)
J. Clin. Microbiol.
43, 791-795
|Abstract »|Full Text »|PDF »
Differential Effects of Vasodilatory Prostaglandins on Focal Adhesions, Cytoskeletal Architecture, and Migration in Human Aortic Smooth Muscle Cells.
C. Bulin, U. Albrecht, J.G. Bode, A.-A. Weber, K. Schror, B. Levkau, and J.W. Fischer (2005)
Arterioscler Thromb Vasc Biol
25, 84-89
|Abstract »|Full Text »|PDF »
Induction of peripheral lymph node addressin in human gastric mucosa infected by Helicobacter pylori.
M. Kobayashi, J. Mitoma, N. Nakamura, T. Katsuyama, J. Nakayama, and M. Fukuda (2004)
PNAS
101, 17807-17812
|Abstract »|Full Text »|PDF »
Intact Gram-Negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus Bacteria Activate Innate Immunity via Toll-Like Receptor 2 but Not Toll-Like Receptor 4.
L. Mandell, A. P. Moran, A. Cocchiarella, J. Houghton, N. Taylor, J. G. Fox, T. C. Wang, and E. A. Kurt-Jones (2004)
Infect. Immun.
72, 6446-6454
|Abstract »|Full Text »|PDF »
Phosphorylation-Independent Effects of CagA during Interaction between Helicobacter pylori and T84 Polarized Monolayers.
S. H. El-Etr, A. Mueller, L. S. Tompkins, S. Falkow, and D. S. Merrell (2004)
The Journal of Infectious Disease
190, 1516-1523
|Abstract »|Full Text »|PDF »
Transcription Profile of Helicobacter pylori in the Human Stomach Reflects Its Physiology In Vivo.
J. K. Boonjakuakul, M. Syvanen, A. Suryaprasad, C. L. Bowlus, and J. V. Solnick (2004)
The Journal of Infectious Disease
190, 946-956
|Abstract »|Full Text »|PDF »
Natural Antibiotic Function of a Human Gastric Mucin Against Helicobacter pylori Infection.
M. Kawakubo, Y. Ito, Y. Okimura, M. Kobayashi, K. Sakura, S. Kasama, M. N. Fukuda, M. Fukuda, T. Katsuyama, and J. Nakayama (2004)
Science
305, 1003-1006
|Abstract »|Full Text »|PDF »
Helicobacter pylori Induces Apoptosis of Human Monocytes but Not Monocyte-Derived Dendritic Cells: Role of the cag Pathogenicity Island.
M. Galgani, I. Busiello, S. Censini, S. Zappacosta, L. Racioppi, and R. Zarrilli (2004)
Infect. Immun.
72, 4480-4485
|Abstract »|Full Text »|PDF »
Alanine-Threonine Polymorphism of Helicobacter pylori RpoB Is Correlated with Differential Induction of Interleukin-8 in MKN45 Cells.
K.-H. Lee, M.-J. Cho, Y. Yamaoka, D. Y. Graham, Y.-J. Yun, S.-Y. Woo, C.-Y. Lim, K.-S. Ko, B.-J. Kim, H.-C. Jung, et al. (2004)
J. Clin. Microbiol.
42, 3518-3524
|Abstract »|Full Text »|PDF »
Helicobacter pylori Arginase Inhibits T Cell Proliferation and Reduces the Expression of the TCR {zeta}-Chain (CD3{zeta}).
J. Zabaleta, D. J. McGee, A. H. Zea, C. P. Hernandez, P. C. Rodriguez, R. A. Sierra, P. Correa, and A. C. Ochoa (2004)
J. Immunol.
173, 586-593
|Abstract »|Full Text »|PDF »
Helicobacter pylori Induces AGS Cell Motility and Elongation via Independent Signaling Pathways.
S. Moese, M. Selbach, T. Kwok, V. Brinkmann, W. Konig, T. F. Meyer, and S. Backert (2004)
Infect. Immun.
72, 3646-3649
|Abstract »|Full Text »|PDF »
Distinct Diversity of the cag Pathogenicity Island among Helicobacter pylori Strains in Japan.
T. Azuma, A. Yamakawa, S. Yamazaki, M. Ohtani, Y. Ito, A. Muramatsu, H. Suto, Y. Yamazaki, Y. Keida, H. Higashi, et al. (2004)
J. Clin. Microbiol.
42, 2508-2517
|Abstract »|Full Text »|PDF »
A. T. Gewirtz, Y. Yu, U. S. Krishna, D. A. Israel, S. L. Lyons, and R. M. Peek (2004)
The Journal of Infectious Disease
189, 1914-1920
|Abstract »|Full Text »|PDF »
Helicobacter pylori CagA Induces Ras-independent Morphogenetic Response through SHP-2 Recruitment and Activation.
H. Higashi, A. Nakaya, R. Tsutsumi, K. Yokoyama, Y. Fujii, S. Ishikawa, M. Higuchi, A. Takahashi, Y. Kurashima, Y. Teishikata, et al. (2004)
J. Biol. Chem.
279, 17205-17216
|Abstract »|Full Text »|PDF »
Association between Diversity in the Src Homology 2 Domain-Containing Tyrosine Phosphatase Binding Site of Helicobacter pylori CagA Protein and Gastric Atrophy and Cancer.
T. Azuma, S. Yamazaki, A. Yamakawa, M. Ohtani, A. Muramatsu, H. Suto, Y. Ito, M. Dojo, Y. Yamazaki, M. Kuriyama, et al. (2004)
The Journal of Infectious Disease
189, 820-827
|Abstract »|Full Text »|PDF »
Functional Analysis of the cag Pathogenicity Island in Helicobacter pylori Isolates from Patients with Gastritis, Peptic Ulcer, and Gastric Cancer.
S. Backert, T. Schwarz, S. Miehlke, C. Kirsch, C. Sommer, T. Kwok, M. Gerhard, U. B. Goebel, N. Lehn, W. Koenig, et al. (2004)
Infect. Immun.
72, 1043-1056
|Abstract »|Full Text »|PDF »
Plasticity of Repetitive DNA Sequences within a Bacterial (Type IV) Secretion System Component.
R. A. Aras, W. Fischer, G. I. Perez-Perez, M. Crosatti, T. Ando, R. Haas, and M. J. Blaser (2003)
J. Exp. Med.
198, 1349-1360
|Abstract »|Full Text »|PDF »
Correlation between cag Pathogenicity Island Composition and Helicobacter pylori-Associated Gastroduodenal Disease.
C. Nilsson, A. Sillen, L. Eriksson, M.-L. Strand, H. Enroth, S. Normark, P. Falk, and L. Engstrand (2003)
Infect. Immun.
71, 6573-6581
|Abstract »|Full Text »|PDF »
