Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors
Carlos Lois,*Elizabeth J. Hong,*Shirley Pease,Eric J. Brown,David Baltimore
Single-cell mouse embryos were infected in vitro with recombinant
lentiviral vectors to generate transgenic mice carryingthe green
fluorescent protein (GFP) gene driven by a ubiquitouslyexpressing
promoter. Eighty percent of founder mice carried atleast
one copy of the transgene, and 90% of these expressed GFPat high
levels. Progeny inherited the transgene(s) and displayedgreen
fluorescence. Mice generated using lentiviral vectors withmuscle-specific and T lymphocyte-specific promoters expressedhigh levels of GFP only in the appropriate cell types. We havealso
generated transgenic rats that express GFP at high levels,suggesting
that this technique can be used to produce other transgenicanimal
species.
Division of Biology, California Institute of Technology, Pasadena,
CA 91125, USA.
*
These authors contributed equally to this work.
To whom correspondence should be addressed. E-mail:
baltimo{at}caltech.edu
The editors suggest the following Related Resources on Science sites:
Forced miR-146a expression causes autoimmune lymphoproliferative syndrome in mice via downregulation of Fas in germinal center B cells.
Q. Guo, J. Zhang, J. Li, L. Zou, J. Zhang, Z. Xie, X. Fu, S. Jiang, G. Chen, Q. Jia, et al. (2013)
Blood
121, 4875-4883
|Abstract »|Full Text »|PDF »
A Switch Between Topological Domains Underlies HoxD Genes Collinearity in Mouse Limbs.
G. Andrey, T. Montavon, B. Mascrez, F. Gonzalez, D. Noordermeer, M. Leleu, D. Trono, F. Spitz, and D. Duboule (2013)
Science
340, 1234167
|Abstract »|Full Text »|PDF »
A Secreted PTEN Phosphatase that Enters Cells to Alter Signaling and Survival.
B. D. Hopkins, B. Fine, N. Steinbach, M. Dendy, Z. Rapp, J. Shaw, K. Pappas, J. S. Yu, C. Hodakoski, S. Mense, et al. (2013)
Science
|Abstract »
From remote enhancers to gene regulation: charting the genome's regulatory landscapes.
Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits.
K. Katter, A. M. Geurts, O. Hoffmann, L. Mates, V. Landa, L. Hiripi, C. Moreno, J. Lazar, S. Bashir, V. Zidek, et al. (2013)
FASEB J
27, 930-941
|Abstract »|Full Text »|PDF »
Pseudotyped retroviruses for infecting axolotl in vivo and in vitro.
J. L. Whited, S. L. Tsai, K. T. Beier, J. N. White, N. Piekarski, J. Hanken, C. L. Cepko, and C. J. Tabin (2013)
Development
140, 1137-1146
|Abstract »|Full Text »|PDF »
Characterizing the conductance underlying depolarization-induced slow current in cerebellar Purkinje cells.
Y. S. Kim, E. Kang, Y. Makino, S. Park, J. H. Shin, H. Song, P. Launay, and D. J. Linden (2013)
J Neurophysiol
109, 1174-1181
|Abstract »|Full Text »|PDF »
Nipah Virus Envelope-Pseudotyped Lentiviruses Efficiently Target ephrinB2-Positive Stem Cell Populations In Vitro and Bypass the Liver Sink When Administered In Vivo.
K. Palomares, F. Vigant, B. Van Handel, O. Pernet, K. Chikere, P. Hong, S. P. Sherman, M. Patterson, D. S. An, W. E. Lowry, et al. (2013)
J. Virol.
87, 2094-2108
|Abstract »|Full Text »|PDF »
In vivo genetic manipulation of cortical progenitors in gyrencephalic carnivores using in utero electroporation.
Insertional Mutagenesis by a Hybrid PiggyBac and Sleeping Beauty Transposon in the Rat.
K. Furushima, C.-W. Jang, D. W. Chen, N. Xiao, P. A. Overbeek, and R. R. Behringer (2012)
Genetics
192, 1235-1248
|Abstract »|Full Text »|PDF »
Inhibitory effect of HIV-specific neutralizing IgA on mucosal transmission of HIV in humanized mice.
E. M. Hur, S. N. Patel, S. Shimizu, D. S. Rao, P. N. P. Gnanapragasam, D. S. An, L. Yang, and D. Baltimore (2012)
Blood
120, 4571-4582
|Abstract »|Full Text »|PDF »
Hyperactive self-inactivating piggyBac for transposase-enhanced pronuclear microinjection transgenesis.
J. Marh, Z. Stoytcheva, J. Urschitz, A. Sugawara, H. Yamashiro, J. B. Owens, I. Stoytchev, P. Pelczar, R. Yanagimachi, and S. Moisyadi (2012)
PNAS
109, 19184-19189
|Abstract »|Full Text »|PDF »
Susceptibility to bystander DNA damage is influenced by replication and transcriptional activity.
J. S. Dickey, B. J. Baird, C. E. Redon, V. Avdoshina, G. Palchik, J. Wu, A. Kondratyev, W. M. Bonner, and O. A. Martin (2012)
Nucleic Acids Res.
40, 10274-10286
|Abstract »|Full Text »|PDF »
Local axonal function of STAT3 rescues axon degeneration in the pmn model of motoneuron disease.
B. T. Selvaraj, N. Frank, F. L. P. Bender, E. Asan, and M. Sendtner (2012)
J. Cell Biol.
199, 437-451
|Abstract »|Full Text »|PDF »
Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via {beta}-catenin signaling.
T. Stoyanova, A. S. Goldstein, H. Cai, J. M. Drake, J. Huang, and O. N. Witte (2012)
Genes & Dev.
26, 2271-2285
|Abstract »|Full Text »|PDF »
Transcriptional Response to Calcium-Sensing Receptor Stimulation.
Phosphorylation of Gephyrin in Hippocampal Neurons by Cyclin-dependent Kinase CDK5 at Ser-270 Is Dependent on Collybistin.
J. Kuhse, H. Kalbouneh, A. Schlicksupp, S. Mukusch, R. Nawrotzki, and J. Kirsch (2012)
J. Biol. Chem.
287, 30952-30966
|Abstract »|Full Text »|PDF »
GluN2B-Containing NMDA Receptors Promote Wiring of Adult-Born Neurons into Olfactory Bulb Circuits.
W. Kelsch, Z. Li, M. Eliava, C. Goengrich, and H. Monyer (2012)
J. Neurosci.
32, 12603-12611
|Abstract »|Full Text »|PDF »
Silencing of IkB{beta} mRNA causes disruption of mitochondrial retrograde signaling and suppression of tumor growth in vivo.
W. Tang, A. R. Chowdhury, M. Guha, L. Huang, T. V. Winkle, A. K. Rustgi, and N. G. Avadhani (2012)
Carcinogenesis
33, 1762-1768
|Abstract »|Full Text »|PDF »
Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism.
W. Yi, P. M. Clark, D. E. Mason, M. C. Keenan, C. Hill, W. A. Goddard III, E. C. Peters, E. M. Driggers, and L. C. Hsieh-Wilson (2012)
Science
337, 975-980
|Abstract »|Full Text »|PDF »
Multiple Roles for Mammalian Target of Rapamycin Signaling in Both Glutamatergic and GABAergic Synaptic Transmission.
M. C. Weston, H. Chen, and J. W. Swann (2012)
J. Neurosci.
32, 11441-11452
|Abstract »|Full Text »|PDF »
Focal adhesion kinase is a phospho-regulated repressor of Rac and proliferation in human endothelial cells.
Formation of Golgi-Derived Active Zone Precursor Vesicles.
C. Maas, V. I. Torres, W. D. Altrock, S. Leal-Ortiz, D. Wagh, R. T. Terry-Lorenzo, A. Fejtova, E. D. Gundelfinger, N. E. Ziv, and C. C. Garner (2012)
J. Neurosci.
32, 11095-11108
|Abstract »|Full Text »|PDF »
The Kruppel-associated Box Repressor Domain Can Induce Reversible Heterochromatization of a Mouse Locus in Vivo.
A. C. Groner, P. Tschopp, L. Challet, J.-E. Dietrich, S. Verp, S. Offner, I. Barde, I. Rodriguez, T. Hiiragi, and D. Trono (2012)
J. Biol. Chem.
287, 25361-25369
|Abstract »|Full Text »|PDF »
FoxP2 is a Parvocellular-Specific Transcription Factor in the Visual Thalamus of Monkeys and Ferrets.
L. Iwai, Y. Ohashi, D. van der List, W. M. Usrey, Y. Miyashita, and H. Kawasaki (2012)
Cereb Cortex
|Abstract »|Full Text »|PDF »
Critical Role of Egr Transcription Factors in Regulating Insulin Biosynthesis, Blood Glucose Homeostasis, and Islet Size.
I. Muller, O. G. Rossler, C. Wittig, M. D. Menger, and G. Thiel (2012)
Endocrinology
153, 3040-3053
|Abstract »|Full Text »|PDF »
MicroRNA-124 Is a Subventricular Zone Neuronal Fate Determinant.
M. Akerblom, R. Sachdeva, I. Barde, S. Verp, B. Gentner, D. Trono, and J. Jakobsson (2012)
J. Neurosci.
32, 8879-8889
|Abstract »|Full Text »|PDF »
Suppression of Tak1 Promotes Prostate Tumorigenesis.
M. Wu, L. Shi, A. Cimic, L. Romero, G. Sui, C. J. Lees, J. M. Cline, D. F. Seals, J. S. Sirintrapun, T. P. McCoy, et al. (2012)
Cancer Res.
72, 2833-2843
|Abstract »|Full Text »|PDF »
Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage.
Y. Kageyama, Z. Zhang, R. Roda, M. Fukaya, J. Wakabayashi, N. Wakabayashi, T. W. Kensler, P. H. Reddy, M. Iijima, and H. Sesaki (2012)
J. Cell Biol.
197, 535-551
|Abstract »|Full Text »|PDF »
Expression of XBP1s in bone marrow stromal cells is critical for myeloma cell growth and osteoclast formation.
G. Xu, K. Liu, J. Anderson, K. Patrene, S. Lentzsch, G. D. Roodman, and H. Ouyang (2012)
Blood
119, 4205-4214
|Abstract »|Full Text »|PDF »
Evidence for a Fragile X Mental Retardation Protein-Mediated Translational Switch in Metabotropic Glutamate Receptor-Triggered Arc Translation and Long-Term Depression.
F. Niere, J. R. Wilkerson, and K. M. Huber (2012)
J. Neurosci.
32, 5924-5936
|Abstract »|Full Text »|PDF »
Abl regulates smooth muscle cell proliferation by modulating actin dynamics and ERK1/2 activation.
L. Jia, R. Wang, and D. D. Tang (2012)
Am J Physiol Cell Physiol
302, C1026-C1034
|Abstract »|Full Text »|PDF »
Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive GABAA receptors in cortical pyramidal cells.
M. Sumegi, Y. Fukazawa, K. Matsui, A. Lorincz, M. D. Eyre, Z. Nusser, and R. Shigemoto (2012)
J. Physiol.
590, 1517-1534
|Abstract »|Full Text »|PDF »
Generation of a Novel Nucleic Acid-Based Reporter System To Detect Phenotypic Susceptibility to Antibiotics in Mycobacterium tuberculosis.
M. C. Mulvey, K. A. Sacksteder, L. Einck, and C. A. Nacy (2012)
mBio
3, e00312-11
|Abstract »|Full Text »|PDF »
Stimulation of Skin and Wound Fibroblast Migration by Mesenchymal Stem Cells Derived from Normal Donors and Chronic Wound Patients.
L. Rodriguez-Menocal, M. Salgado, D. Ford, and E. Van Badiavas (2012)
Stem Cells Trans Med
1, 221-229
|Abstract »|Full Text »|PDF »
Lentiviral-Mediated RNAi Knockdown Yields a Novel Mouse Model for Studying Cyp2b Function.
B. Damiri, E. Holle, X. Yu, and W. S. Baldwin (2012)
Toxicol. Sci.
125, 368-381
|Abstract »|Full Text »|PDF »
Omental Adipose Tissue-Derived Stromal Cells Promote Vascularization and Growth of Endometrial Tumors.
A. H. Klopp, Y. Zhang, T. Solley, F. Amaya-Manzanares, F. Marini, M. Andreeff, B. Debeb, W. Woodward, R. Schmandt, R. Broaddus, et al. (2012)
Clin. Cancer Res.
18, 771-782
|Abstract »|Full Text »|PDF »
Wandering Neuronal Migration in the Postnatal Vertebrate Forebrain.
B. B. Scott, T. Gardner, N. Ji, M. S. Fee, and C. Lois (2012)
J. Neurosci.
32, 1436-1446
|Abstract »|Full Text »|PDF »
Determinants of Microvascular Network Topologies in Implanted Neovasculatures.
C. C. Chang, L. Krishnan, S. S. Nunes, K. H. Church, L. T. Edgar, E. D. Boland, J. A. Weiss, S. K. Williams, and J. B. Hoying (2012)
Arterioscler Thromb Vasc Biol
32, 5-14
|Abstract »|Full Text »|PDF »
pTransgenesis: a cross-species, modular transgenesis resource.
N. R. Love, R. Thuret, Y. Chen, S. Ishibashi, N. Sabherwal, R. Paredes, J. Alves-Silva, K. Dorey, A. M. Noble, M. J. Guille, et al. (2011)
Development
138, 5451-5458
|Abstract »|Full Text »|PDF »
Separating spermatogonia from cancer cells in contaminated prepubertal primate testis cell suspensions.
B. P. Hermann, M. Sukhwani, J. Salati, Y. Sheng, T. Chu, and K. E. Orwig (2011)
Hum. Reprod.
26, 3222-3231
|Abstract »|Full Text »|PDF »
Use Dependence of Presynaptic Tenacity.
A. Fisher-Lavie, A. Zeidan, M. Stern, C. C. Garner, and N. E. Ziv (2011)
J. Neurosci.
31, 16770-16780
|Abstract »|Full Text »|PDF »
Immediate-Early Transcriptional Response to Angiotensin II in Human Adrenocortical Cells.
The Ect2 Rho Guanine Nucleotide Exchange Factor Is Essential for Early Mouse Development and Normal Cell Cytokinesis and Migration.
D. R. Cook, P. A. Solski, S. J. Bultman, G. Kauselmann, M. Schoor, R. Kuehn, L. S. Friedman, D. O. Cowley, T. Van Dyke, J. J. Yeh, et al. (2011)
Genes & Cancer
2, 932-942
|Abstract »|Full Text »|PDF »
SAP97 directs NMDA receptor spine targeting and synaptic plasticity.
D. Li, C. G. Specht, C. L. Waites, C. Butler-Munro, S. Leal-Ortiz, J. W. Foote, D. Genoux, C. C. Garner, and J. M. Montgomery (2011)
J. Physiol.
589, 4491-4510
|Abstract »|Full Text »|PDF »
Comparative promoter analysis in vivo: identification of a dendritic cell-specific promoter module.
Gammaherpesvirus 68 Infection of Endothelial Cells Requires both Host Autophagy Genes and Viral Oncogenes for Optimal Survival and Persistence.
A. L. Suarez, R. Kong, T. George, L. He, Z. Yue, and L. F. van Dyk (2011)
J. Virol.
85, 6293-6308
|Abstract »|Full Text »|PDF »
miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice.
M. P. Boldin, K. D. Taganov, D. S. Rao, L. Yang, J. L. Zhao, M. Kalwani, Y. Garcia-Flores, M. Luong, A. Devrekanli, J. Xu, et al. (2011)
J. Exp. Med.
208, 1189-1201
|Abstract »|Full Text »|PDF »
Development of Glioblastoma Cell Lines Expressing Red Fluorescence for Non-invasive Live Imaging of Intracranial Tumors.
M. VERREAULT, D. STRUTT, D. MASIN, D. FINK, R. GILL, and M. B. BALLY (2011)
Anticancer Res
31, 2161-2171
|Abstract »|Full Text »|PDF »
TRIM22 Inhibits HIV-1 Transcription Independently of Its E3 Ubiquitin Ligase Activity, Tat, and NF-{kappa}B-Responsive Long Terminal Repeat Elements.
A. Kajaste-Rudnitski, S. S. Marelli, C. Pultrone, T. Pertel, P. D. Uchil, N. Mechti, W. Mothes, G. Poli, J. Luban, and E. Vicenzi (2011)
J. Virol.
85, 5183-5196
|Abstract »|Full Text »|PDF »
Peripheral T Cells Re-Enter the Thymus and Interfere with Central Tolerance Induction.
S. L. Edelmann, P. Marconi, and T. Brocker (2011)
J. Immunol.
186, 5612-5619
|Abstract »|Full Text »|PDF »
Quantitative Cell-based Protein Degradation Assays to Identify and Classify Drugs That Target the Ubiquitin-Proteasome System.
Site-specific integrase-mediated transgenesis in mice via pronuclear injection.
B. Tasic, S. Hippenmeyer, C. Wang, M. Gamboa, H. Zong, Y. Chen-Tsai, and L. Luo (2011)
PNAS
108, 7902-7907
|Abstract »|Full Text »|PDF »
AAV and Compacted DNA Nanoparticles for the Treatment of Retinal Disorders: Challenges and Future Prospects.
Z. Han, S. M. Conley, and M. I. Naash (2011)
Invest. Ophthalmol. Vis. Sci.
52, 3051-3059
|Abstract »|Full Text »|PDF »
PSD-95 Is Required to Sustain the Molecular Organization of the Postsynaptic Density.
X. Chen, C. D. Nelson, X. Li, C. A. Winters, R. Azzam, A. A. Sousa, R. D. Leapman, H. Gainer, M. Sheng, and T. S. Reese (2011)
J. Neurosci.
31, 6329-6338
|Abstract »|Full Text »|PDF »
EphA4 preserves postnatal and adult neural stem cells in an undifferentiated state in vivo.
K. Khodosevich, Y. Watanabe, and H. Monyer (2011)
J. Cell Sci.
124, 1268-1279
|Abstract »|Full Text »|PDF »
A Requirement for Nuclear Factor-{kappa}B in Developmental and Plasticity-Associated Synaptogenesis.
M. C. H. Boersma, E. C. Dresselhaus, L. M. De Biase, A. B. Mihalas, D. E. Bergles, and M. K. Meffert (2011)
J. Neurosci.
31, 5414-5425
|Abstract »|Full Text »|PDF »
Generation of Transgenic Mice on an NOD/SCID Background Using the Conventional Microinjection Technique.
K. Kumagai, N. Kubota, T. I. Saito, T. Sasako, R. Takizawa, K. Sudo, M. Kurokawa, and T. Kadowaki (2011)
Biol Reprod
84, 682-688
|Abstract »|Full Text »|PDF »
Signal Transduction of Pregnenolone Sulfate in Insulinoma Cells: ACTIVATION OF EGR-1 EXPRESSION INVOLVING TRPM3, VOLTAGE-GATED CALCIUM CHANNELS, ERK, AND TERNARY COMPLEX FACTORS.
S. I. Mayer, I. Muller, S. Mannebach, T. Endo, and G. Thiel (2011)
J. Biol. Chem.
286, 10084-10096
|Abstract »|Full Text »|PDF »
Pten Knockdown In Vivo Increases Excitatory Drive onto Dentate Granule Cells.
B. W. Luikart, E. Schnell, E. K. Washburn, A. L. Bensen, K. R. Tovar, and G. L. Westbrook (2011)
J. Neurosci.
31, 4345-4354
|Abstract »|Full Text »|PDF »
p120 regulates endothelial permeability independently of its NH2 terminus and Rho binding.
C. R. Herron, A. M. Lowery, P. R. Hollister, A. B. Reynolds, and P. A. Vincent (2011)
Am J Physiol Heart Circ Physiol
300, H36-H48
|Abstract »|Full Text »|PDF »
Axonal Degeneration Is Blocked by Nicotinamide Mononucleotide Adenylyltransferase (Nmnat) Protein Transduction into Transected Axons.
In vivo efficacy of platelet-delivered, high specific activity factor VIII variants.
T. K. Greene, C. Wang, J. D. Hirsch, L. Zhai, J. Gewirtz, M. A. Thornton, H. Z. Miao, S. W. Pipe, R. J. Kaufman, R. M. Camire, et al. (2010)
Blood
116, 6114-6122
|Abstract »|Full Text »|PDF »
Cytoplasmic Poly(A) Binding Proteins Regulate Telomerase Activity and Cell Growth in Human Papillomavirus Type 16 E6-Expressing Keratinocytes.
R. A. Katzenellenbogen, P. Vliet-Gregg, M. Xu, and D. A. Galloway (2010)
J. Virol.
84, 12934-12944
|Abstract »|Full Text »|PDF »
Reversal of preexisting hyperglycemia in diabetic mice by acute deletion of the Men1 gene.
Y. Yang, B. Gurung, T. Wu, H. Wang, D. A. Stoffers, and X. Hua (2010)
PNAS
107, 20358-20363
|Abstract »|Full Text »|PDF »
Affinity purification of microRNA-133a with the cardiac transcription factor, Hand2.
N. K. Vo, R. P. Dalton, N. Liu, E. N. Olson, and R. H. Goodman (2010)
PNAS
107, 19231-19236
|Abstract »|Full Text »|PDF »
Thapsigargin Induces Expression of Activating Transcription Factor 3 in Human Keratinocytes Involving Ca2+ Ions and c-Jun N-Terminal Protein Kinase.
D. Spohn, O. G. Rossler, S. E. Philipp, M. Raubuch, S. Kitajima, D. Griesemer, M. Hoth, and G. Thiel (2010)
Mol. Pharmacol.
78, 865-876
|Abstract »|Full Text »|PDF »
CDKL5, a Protein Associated with Rett Syndrome, Regulates Neuronal Morphogenesis via Rac1 Signaling.
Q. Chen, Y.-C. Zhu, J. Yu, S. Miao, J. Zheng, L. Xu, Y. Zhou, D. Li, C. Zhang, J. Tao, et al. (2010)
J. Neurosci.
30, 12777-12786
|Abstract »|Full Text »|PDF »
H. Hsin, M. J. Kim, C.-F. Wang, and M. Sheng (2010)
J. Neurosci.
30, 11983-11993
|Abstract »|Full Text »|PDF »
Dynamic plasticity of large-scale chromatin structure revealed by self-assembly of engineered chromosome regions.
P. Sinclair, Q. Bian, M. Plutz, E. Heard, and A. S. Belmont (2010)
J. Cell Biol.
190, 761-776
|Abstract »|Full Text »|PDF »
c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development.
Y. Nakata, A. C. Brignier, S. Jin, Y. Shen, S. I. Rudnick, M. Sugita, and A. M. Gewirtz (2010)
Blood
116, 1280-1290
|Abstract »|Full Text »|PDF »
Factor IX ectopically expressed in platelets can be stored in {alpha}-granules and corrects the phenotype of hemophilia B mice.
G. Zhang, Q. Shi, S. A. Fahs, E. L. Kuether, C. E. Walsh, and R. R. Montgomery (2010)
Blood
116, 1235-1243
|Abstract »|Full Text »|PDF »
Transmembrane Protein 147 (TMEM147) Is a Novel Component of the Nicalin-NOMO Protein Complex.
U. Dettmer, P.-H. Kuhn, C. Abou-Ajram, S. F. Lichtenthaler, M. Kruger, E. Kremmer, C. Haass, and C. Haffner (2010)
J. Biol. Chem.
285, 26174-26181
|Abstract »|Full Text »|PDF »
Type 1 Diabetes in BioBreeding Rats Is Critically Linked to an Imbalance between Th17 and Regulatory T Cells and an Altered TCR Repertoire.
J. van den Brandt, H. J. Fischer, L. Walter, T. Hunig, I. Kloting, and H. M. Reichardt (2010)
J. Immunol.
185, 2285-2294
|Abstract »|Full Text »|PDF »
Human Cytomegalovirus pUL83 Stimulates Activity of the Viral Immediate-Early Promoter through Its Interaction with the Cellular IFI16 Protein.
I. M. Cristea, N. J. Moorman, S. S. Terhune, C. D. Cuevas, E. S. O'Keefe, M. P. Rout, B. T. Chait, and T. Shenk (2010)
J. Virol.
84, 7803-7814
|Abstract »|Full Text »|PDF »
Cyclic AMP Suppression Is Sufficient to Induce Gliomagenesis in a Mouse Model of Neurofibromatosis-1.
N. M. Warrington, S. M. Gianino, E. Jackson, P. Goldhoff, J. R. Garbow, D. Piwnica-Worms, D. H. Gutmann, and J. B. Rubin (2010)
Cancer Res.
70, 5717-5727
|Abstract »|Full Text »|PDF »
The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons.
C. Y. Chung, P. Licznerski, K. N. Alavian, A. Simeone, Z. Lin, E. Martin, J. Vance, and O. Isacson (2010)
Brain
133, 2022-2031
|Abstract »|Full Text »|PDF »
Human CD34+ Cells in Experimental Myocardial Infarction: Long-Term Survival, Sustained Functional Improvement, and Mechanism of Action.
J. Wang, S. Zhang, B. Rabinovich, L. Bidaut, S. Soghomonyan, M. M. Alauddin, J. A. Bankson, E. Shpall, J. T. Willerson, J. G. Gelovani, et al. (2010)
Circ. Res.
106, 1904-1911
|Abstract »|Full Text »|PDF »
Dipeptidyl Peptidase-Like Protein 6 Is Required for Normal Electrophysiological Properties of Cerebellar Granule Cells.
Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors.
R. Sachdeva, M. E. Jonsson, J. Nelander, A. Kirkeby, C. Guibentif, B. Gentner, L. Naldini, A. Bjorklund, M. Parmar, and J. Jakobsson (2010)
PNAS
107, 11602-11607
|Abstract »|Full Text »|PDF »
C/EBP{beta} expression in ALK-positive anaplastic large cell lymphomas is required for cell proliferation and is induced by the STAT3 signaling pathway.
N. Anastasov, I. Bonzheim, M. Rudelius, M. Klier, T. Dau, D. Angermeier, J. Duyster, S. Pittaluga, F. Fend, M. Raffeld, et al. (2010)
Haematologica
95, 760-767
|Abstract »|Full Text »|PDF »
Implantation increases tensile strength and collagen content of self-assembled tendon constructs.
S. Calve, I. F. Lytle, K. Grosh, D. L. Brown, and E. M. Arruda (2010)
J Appl Physiol
108, 875-881
|Abstract »|Full Text »|PDF »
Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCF{beta}-TrCP by single substrate depletion.
N. Kanarek, E. Horwitz, I. Mayan, M. Leshets, G. Cojocaru, M. Davis, B.-Z. Tsuberi, E. Pikarsky, M. Pagano, and Y. Ben-Neriah (2010)
Genes & Dev.
24, 470-477
|Abstract »|Full Text »|PDF »
