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Science 295 (5559): 1528-1532

Copyright © 2002 by the American Association for the Advancement of Science

Transcriptional Regulation of Cortical Neuron Migration by POU Domain Factors

Robert J. McEvilly,* Marcela Ortiz de Diaz, Marcus D. Schonemann, Farideh Hooshmand, Michael G. Rosenfeld*

The identification of pathways mediated by the kinase Cdk5 and the ligand reelin has provided a conceptual framework for exploring the molecular mechanisms underlying proper lamination of the developing mammalian cerebral cortex. In this report, we identify a component of the regulation of Cdk5-mediated cortical lamination by genetic analysis of the roles of the class III POU domain transcription factors, Brn-1 and Brn-2, expressed during the development of the forebrain and coexpressed in most layer II-V cortical neurons. Brn-1 and Brn-2 appear to critically control the initiation of radial migration, redundantly regulating the cell-autonomous expression of the p35 and p39 regulatory subunits of Cdk5 in migrating cortical neurons, with Brn-1(-/-)/Brn-2(-/-) mice exhibiting cortical inversion.

Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92037-0648, USA.
*   To whom correspondence should be addressed. E-mail: rmcevilly{at}ucsd.edu, mrosenfeld{at}ucsd.edu

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