Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Subscribe

Logo for

Science 295 (5560): 1708-1711

Copyright © 2002 by the American Association for the Advancement of Science

Imaging Sites of Receptor Dephosphorylation by PTP1B on the Surface of the Endoplasmic Reticulum

Fawaz G. Haj,1 Peter J. Verveer,2 Anthony Squire,2 Benjamin G. Neel,1* Philippe I. H. Bastiaens2*

When bound by extracellular ligands, receptor tyrosine kinases (RTKs) on the cell surface transmit critical signals to the cell interior. Although signal termination is less well understood, protein tyrosine phosphatase-1B (PTP1B) is implicated in the dephosphorylation and inactivation of several RTKs. However, PTP1B resides on the cytoplasmic surface of the endoplasmic reticulum (ER), so how and when it accesses RTKs has been unclear. Using fluorescence resonance energy transfer (FRET) methods, we monitored interactions between the epidermal- and platelet-derived growth factor receptors and PTP1B. PTP1B-catalyzed dephosphorylation required endocytosis of the receptors and occurred at specific sites on the surface of the ER. Most of the RTKs activated at the cell surface showed interaction with PTP1B after internalization, establishing that RTK activation and inactivation are spatially and temporally partitioned within cells.

1 Cancer Biology Program, Division of Hematology-Oncology, Department of Medicine, Beth Israel-Deaconess Medical Center, Boston, MA 02115, USA.
2 European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
*   To whom correspondence should be addressed. E-mail: bneel{at}caregroup.harvard.edu (B.G.N.), bastiaen{at}embl-heidelberg.de (P.I.H.B.)

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
PTP1B promotes focal complex maturation, lamellar persistence and directional migration.
J. E. Burdisso, A. Gonzalez, and C. O. Arregui (2013)
J. Cell Sci. 126, 1820-1831
   Abstract »    Full Text »    PDF »
The Nucleus- and Endoplasmic Reticulum-Targeted Forms of Protein Tyrosine Phosphatase 61F Regulate Drosophila Growth, Life Span, and Fecundity.
B. J. Buszard, T. K. Johnson, T.-C. Meng, R. Burke, C. G. Warr, and T. Tiganis (2013)
Mol. Cell. Biol. 33, 1345-1356
   Abstract »    Full Text »    PDF »
Imaging EGFR Phosphorylation in Intact Human Pancreatic Carcinoma Cells.
R. MAGDEBURG, M. KESSLER, R. BOENNINGHOFF, and M. KEESE (2012)
In Vivo 26, 619-625
   Abstract »    Full Text »    PDF »
Endocytosis and Signaling: Cell Logistics Shape the Eukaryotic Cell Plan.
S. Sigismund, S. Confalonieri, A. Ciliberto, S. Polo, G. Scita, and P. P. Di Fiore (2012)
Physiol Rev 92, 273-366
   Abstract »    Full Text »    PDF »
Protein-tyrosine Phosphatase 1B Modulates Early Endosome Fusion and Trafficking of Met and Epidermal Growth Factor Receptors.
V. Sangwan, J. Abella, A. Lai, N. Bertos, M. Stuible, M. L. Tremblay, and M. Park (2011)
J. Biol. Chem. 286, 45000-45013
   Abstract »    Full Text »    PDF »
Peroxiredoxin-controlled G-CSF signalling at the endoplasmic reticulum-early endosome interface.
K. Palande, O. Roovers, J. Gits, C. Verwijmeren, Y. Iuchi, J. Fujii, B. G. Neel, R. Karisch, J. Tavernier, and I. P. Touw (2011)
J. Cell Sci. 124, 3695-3705
   Abstract »    Full Text »    PDF »
Regulation of epidermal growth factor receptor signalling by inducible feedback inhibitors.
O. Segatto, S. Anastasi, and S. Alema (2011)
J. Cell Sci. 124, 1785-1793
   Abstract »    Full Text »    PDF »
PTP1B regulates Eph receptor function and trafficking.
E. Nievergall, P. W. Janes, C. Stegmayer, M. E. Vail, F. G. Haj, S. W. Teng, B. G. Neel, P. I. Bastiaens, and M. Lackmann (2010)
J. Cell Biol. 191, 1189-1203
   Abstract »    Full Text »    PDF »
Insulin Induces Swelling-dependent Activation of the Epidermal Growth Factor Receptor in Rat Liver.
R. Reinehr, A. Sommerfeld, and D. Haussinger (2010)
J. Biol. Chem. 285, 25904-25912
   Abstract »    Full Text »    PDF »
PTP1B Targets the Endosomal Sorting Machinery: DEPHOSPHORYLATION OF REGULATORY SITES ON THE ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT COMPONENT STAM2.
M. Stuible, J. V. Abella, M. Feldhammer, M. Nossov, V. Sangwan, B. Blagoev, M. Park, and M. L. Tremblay (2010)
J. Biol. Chem. 285, 23899-23907
   Abstract »    Full Text »    PDF »
Protein-tyrosine Phosphatase PTPN9 Negatively Regulates ErbB2 and Epidermal Growth Factor Receptor Signaling in Breast Cancer Cells.
T. Yuan, Y. Wang, Z. J. Zhao, and H. Gu (2010)
J. Biol. Chem. 285, 14861-14870
   Abstract »    Full Text »    PDF »
The Protein Tyrosine Phosphatase PTP1B Is Required for Efficient Delivery of N-Cadherin to the Cell Surface.
M. V. Hernandez, D. P. Wehrendt, and C. O. Arregui (2010)
Mol. Biol. Cell 21, 1387-1397
   Abstract »    Full Text »    PDF »
Prolactin Enhances Insulin-like Growth Factor I Receptor Phosphorylation by Decreasing Its Association with the Tyrosine Phosphatase SHP-2 in MCF-7 Breast Cancer Cells.
K. C. Carver, T. M. Piazza, and L. A. Schuler (2010)
J. Biol. Chem. 285, 8003-8012
   Abstract »    Full Text »    PDF »
Receptor Type Protein Tyrosine Phosphatase-Kappa Mediates Cross-Talk between Transforming Growth Factor-Beta and Epidermal Growth Factor Receptor Signaling Pathways in Human Keratinocytes.
Y. Xu, D. Baker, T. Quan, J. J. Baldassare, J. J. Voorhees, and G. J. Fisher (2010)
Mol. Biol. Cell 21, 29-35
   Abstract »    Full Text »    PDF »
Breakdown of endocytosis in the oncogenic activation of receptor tyrosine kinases.
J. V. Abella and M. Park (2009)
Am J Physiol Endocrinol Metab 296, E973-E984
   Abstract »    Full Text »    PDF »
Microtubule and Cell Contact Dependency of ER-bound PTP1B Localization in Growth Cones.
F. Fuentes and C. O. Arregui (2009)
Mol. Biol. Cell 20, 1878-1889
   Abstract »    Full Text »    PDF »
A quantitative protocol for dynamic measurements of protein interactions by Forster resonance energy transfer-sensitized fluorescence emission.
A.D Elder, A Domin, G.S Kaminski Schierle, C Lindon, J Pines, A Esposito, and C.F Kaminski (2009)
J R Soc Interface 6, S59-S81
   Abstract »    Full Text »    PDF »
Regulation of the Met Receptor-tyrosine Kinase by the Protein-tyrosine Phosphatase 1B and T-cell Phosphatase.
V. Sangwan, G. N. Paliouras, J. V. Abella, N. Dube, A. Monast, M. L. Tremblay, and M. Park (2008)
J. Biol. Chem. 283, 34374-34383
   Abstract »    Full Text »    PDF »
PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling.
X. Lu, R. Malumbres, B. Shields, X. Jiang, K. A. Sarosiek, Y. Natkunam, T. Tiganis, and I. S. Lossos (2008)
Blood 112, 4098-4108
   Abstract »    Full Text »    PDF »
Regulation of ROS signal transduction by NADPH oxidase 4 localization.
K. Chen, M. T. Kirber, H. Xiao, Y. Yang, and J. F. Keaney Jr. (2008)
J. Cell Biol. 181, 1129-1139
   Abstract »    Full Text »    PDF »
Resveratrol inhibits PDGF receptor mitogenic signaling in mesangial cells: role of PTP1B.
B. Venkatesan, N. Ghosh-Choudhury, F. Das, L. Mahimainathan, A. Kamat, B. S. Kasinath, H. E. Abboud, and G. G. Choudhury (2008)
FASEB J 22, 3469-3482
   Abstract »    Full Text »    PDF »
Investigation of Protein-tyrosine Phosphatase 1B Function by Quantitative Proteomics.
P. Mertins, H. C. Eberl, J. Renkawitz, J. V. Olsen, M. L. Tremblay, M. Mann, A. Ullrich, and H. Daub (2008)
Mol. Cell. Proteomics 7, 1763-1777
   Abstract »    Full Text »    PDF »
The Involvement of Abl and PTP61F in the Regulation of Abi Protein Localization and Stability and Lamella Formation in Drosophila S2 Cells.
C.-H. Huang, T.-Y. Lin, R.-L. Pan, and J.-L. Juang (2007)
J. Biol. Chem. 282, 32442-32452
   Abstract »    Full Text »    PDF »
In Situ Detection of Phosphorylated Platelet-derived Growth Factor Receptor {beta} Using a Generalized Proximity Ligation Method.
M. Jarvius, J. Paulsson, I. Weibrecht, K.-J. Leuchowius, A.-C. Andersson, C. Wahlby, M. Gullberg, J. Botling, T. Sjoblom, B. Markova, et al. (2007)
Mol. Cell. Proteomics 6, 1500-1509
   Abstract »    Full Text »    PDF »
GAPex-5 Mediates Ubiquitination, Trafficking, and Degradation of Epidermal Growth Factor Receptor.
X. Su, C. Kong, and P. D. Stahl (2007)
J. Biol. Chem. 282, 21278-21284
   Abstract »    Full Text »    PDF »
The Role of the C-terminal Domain of Protein Tyrosine Phosphatase-1B in Phosphatase Activity and Substrate Binding.
K. M. Picha, S. S. Patel, S. Mandiyan, J. Koehn, and L. P. Wennogle (2007)
J. Biol. Chem. 282, 2911-2917
   Abstract »    Full Text »    PDF »
Live-Cell Imaging of Enzyme-Substrate Interaction Reveals Spatial Regulation of PTP1B.
I. A. Yudushkin, A. Schleifenbaum, A. Kinkhabwala, B. G. Neel, C. Schultz, and P. I. H. Bastiaens (2007)
Science 315, 115-119
   Abstract »    Full Text »    PDF »
Glutaredoxin Modulates Platelet-derived Growth Factor-dependent Cell Signaling by Regulating the Redox Status of Low Molecular Weight Protein-tyrosine Phosphatase.
M. Kanda, Y. Ihara, H. Murata, Y. Urata, T. Kono, J. Yodoi, S. Seto, K. Yano, and T. Kondo (2006)
J. Biol. Chem. 281, 28518-28528
   Abstract »    Full Text »    PDF »
Gene silencing reveals a specific function of hVps34 phosphatidylinositol 3-kinase in late versus early endosomes.
E. E. Johnson, J. H. Overmeyer, W. T. Gunning, and W. A. Maltese (2006)
J. Cell Sci. 119, 1219-1232
   Abstract »    Full Text »    PDF »
ER-bound PTP1B is targeted to newly forming cell-matrix adhesions.
M. V. Hernandez, M. G. D. Sala, J. Balsamo, J. Lilien, and C. O. Arregui (2006)
J. Cell Sci. 119, 1233-1243
   Abstract »    Full Text »    PDF »
Negative Regulation of Growth Hormone Receptor Signaling.
A. Flores-Morales, C. J. Greenhalgh, G. Norstedt, and E. Rico-Bautista (2006)
Mol. Endocrinol. 20, 241-253
   Abstract »    Full Text »    PDF »
Insulin Receptor Kinase-Associated Phosphotyrosine Phosphatases in Hepatic Endosomes: Assessing the Role of Phosphotyrosine Phosphatase-1B.
C. Li, G. Baquiran, F. Gu, M. L. Tremblay, A. Fazel, J. J. M. Bergeron, and B. I. Posner (2006)
Endocrinology 147, 912-918
   Abstract »    Full Text »    PDF »
Exendin-4 Uses Irs2 Signaling to Mediate Pancreatic beta Cell Growth and Function.
S. Park, X. Dong, T. L. Fisher, S. Dunn, A. K. Omer, G. Weir, and M. F. White (2006)
J. Biol. Chem. 281, 1159-1168
   Abstract »    Full Text »    PDF »
Type I Collagen Limits VEGFR-2 Signaling by a SHP2 Protein-Tyrosine Phosphatase-Dependent Mechanism 1.
S. Mitola, B. Brenchio, M. Piccinini, L. Tertoolen, L. Zammataro, G. Breier, M. T. Rinaudo, J. den Hertog, M. Arese, and F. Bussolino (2006)
Circ. Res. 98, 45-54
   Abstract »    Full Text »    PDF »
Oxidative stress and ageing: is ageing a cysteine deficiency syndrome?.
W. Droge (2005)
Phil Trans R Soc B 360, 2355-2372
   Abstract »    Full Text »    PDF »
Oxidative Aging and Insulin Receptor Signaling.
W. Droge (2005)
J Gerontol A Biol Sci Med Sci 60, 1378-1385
   Abstract »    Full Text »    PDF »
Imaging Epidermal Growth Factor Receptor Phosphorylation in Human Colorectal Cancer Cells and Human Tissues.
M. Keese, R. J. Magdeburg, T. Herzog, T. Hasenberg, M. Offterdinger, R. Pepperkok, J. W. Sturm, and P. I. H. Bastiaens (2005)
J. Biol. Chem. 280, 27826-27831
   Abstract »    Full Text »    PDF »
The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions.
T. A. Berset, E. F. Hoier, and A. Hajnal (2005)
Genes & Dev. 19, 1328-1340
   Abstract »    Full Text »    PDF »
Endoplasmic Reticulum-Localized Human Papillomavirus Type 16 E5 Protein Alters Endosomal pH but Not trans-Golgi pH.
G. L. Disbrow, J. A. Hanover, and R. Schlegel (2005)
J. Virol. 79, 5839-5846
   Abstract »    Full Text »    PDF »
c-Cbl Mediates Ubiquitination, Degradation, and Down-regulation of Human Protease-activated Receptor 2.
C. Jacob, G. S. Cottrell, D. Gehringer, F. Schmidlin, E. F. Grady, and N. W. Bunnett (2005)
J. Biol. Chem. 280, 16076-16087
   Abstract »    Full Text »    PDF »
Inhibition of Protein-tyrosine Phosphatases by Mild Oxidative Stresses Is Dependent on S-Nitrosylation.
D. M. Barrett, S. M. Black, H. Todor, R. K. Schmidt-Ullrich, K. S. Dawson, and R. B. Mikkelsen (2005)
J. Biol. Chem. 280, 14453-14461
   Abstract »    Full Text »    PDF »
Liver-specific Protein-tyrosine Phosphatase 1B (PTP1B) Re-expression Alters Glucose Homeostasis of PTP1B-/-Mice.
F. G. Haj, J. M. Zabolotny, Y.-B. Kim, B. B. Kahn, and B. G. Neel (2005)
J. Biol. Chem. 280, 15038-15046
   Abstract »    Full Text »    PDF »
Protein tyrosine phosphatases and signalling.
A. W Stoker (2005)
J. Endocrinol. 185, 19-33
   Abstract »    Full Text »    PDF »
Tyrosine phosphatases in vessel wall signaling.
K. Kappert, K. G. Peters, F. D. Bohmer, and A. Ostman (2005)
Cardiovasc Res 65, 587-598
   Abstract »    Full Text »    PDF »
Redox Paradox: Insulin Action Is Facilitated by Insulin-Stimulated Reactive Oxygen Species With Multiple Potential Signaling Targets.
B. J. Goldstein, K. Mahadev, and X. Wu (2005)
Diabetes 54, 311-321
   Abstract »    Full Text »    PDF »
Hepatic PTP-1B Expression Regulates the Assembly and Secretion of Apolipoprotein B-Containing Lipoproteins: Evidence From Protein Tyrosine Phosphatase-1B Overexpression, Knockout, and RNAi Studies.
W. Qiu, R. K. Avramoglu, N. Dube, T. M. Chong, M. Naples, C. Au, K. G. Sidiropoulos, G. F. Lewis, J. S. Cohn, M. L. Tremblay, et al. (2004)
Diabetes 53, 3057-3066
   Abstract »    Full Text »    PDF »
Heterodimerization and Endocytosis of Arabidopsis Brassinosteroid Receptors BRI1 and AtSERK3 (BAK1).
E. Russinova, J.-W. Borst, M. Kwaaitaal, A. Cano-Delgado, Y. Yin, J. Chory, and S. C. de Vries (2004)
PLANT CELL 16, 3216-3229
   Abstract »    Full Text »    PDF »
The Na+/H+ Exchanger Regulatory Factor Stabilizes Epidermal Growth Factor Receptors at the Cell Surface.
C. S. Lazar, C. M. Cresson, D. A. Lauffenburger, and G. N. Gill (2004)
Mol. Biol. Cell 15, 5470-5480
   Abstract »    Full Text »    PDF »
Protein-tyrosine Phosphatase 1B Potentiates IRE1 Signaling during Endoplasmic Reticulum Stress.
F. Gu, D. T. Nguyen, M. Stuible, N. Dube, M. L. Tremblay, and E. Chevet (2004)
J. Biol. Chem. 279, 49689-49693
   Abstract »    Full Text »    PDF »
Increase of PTP levels in vascular injury and in cultured aortic smooth muscle cells treated with specific growth factors.
Y. Chang, D. Zhuang, C. Zhang, and A. Hassid (2004)
Am J Physiol Heart Circ Physiol 287, H2201-H2208
   Abstract »    Full Text »    PDF »
Apc Deficiency Is Associated with Increased Egfr Activity in the Intestinal Enterocytes and Adenomas of C57BL/6J-Min/+ Mice.
A. E. Moran, D. H. Hunt, S. H. Javid, M. Redston, A. M. Carothers, and M. M. Bertagnolli (2004)
J. Biol. Chem. 279, 43261-43272
   Abstract »    Full Text »    PDF »
Visualization of SHP-1-target interaction.
C. Biskup, A. Bohmer, R. Pusch, L. Kelbauskas, A. Gorshokov, I. Majoul, J. Lindenau, K. Benndorf, and F.-D. Bohmer (2004)
J. Cell Sci. 117, 5165-5178
   Abstract »    Full Text »    PDF »
Regulation of Insulin Signaling through Reversible Oxidation of the Protein-tyrosine Phosphatases TC45 and PTP1B.
T.-C. Meng, D. A. Buckley, S. Galic, T. Tiganis, and N. K. Tonks (2004)
J. Biol. Chem. 279, 37716-37725
   Abstract »    Full Text »    PDF »
Imaging Phosphorylation Dynamics of the Epidermal Growth Factor Receptor.
M. Offterdinger, V. Georget, A. Girod, and P. I. H. Bastiaens (2004)
J. Biol. Chem. 279, 36972-36981
   Abstract »    Full Text »    PDF »
Role of Sphingosine-1-phosphate Phosphatase 1 in Epidermal Growth Factor-induced Chemotaxis.
H. Le Stunff, A. Mikami, P. Giussani, J. P Hobson, P. S. Jolly, S. Milstien, and S. Spiegel (2004)
J. Biol. Chem. 279, 34290-34297
   Abstract »    Full Text »    PDF »
Protein-Tyrosine Phosphatase 1B Associates with Insulin Receptor and Negatively Regulates Insulin Signaling without Receptor Internalization.
K. Shi, K. Egawa, H. Maegawa, T. Nakamura, S. Ugi, Y. Nishio, and A. Kashiwagi (2004)
J. Biochem. 136, 89-96
   Abstract »    Full Text »    PDF »
IIGP, a member of the IFN inducible and microbial defense mediating 47 kDa GTPase family, interacts with the microtubule binding protein hook3.
F. Kaiser, S. H. E. Kaufmann, and J. Zerrahn (2004)
J. Cell Sci. 117, 1747-1756
   Abstract »    Full Text »    PDF »
Inactivation of Platelet-derived Growth Factor Receptor by the Tumor Suppressor PTEN Provides a Novel Mechanism of Action of the Phosphatase.
L. Mahimainathan and G. G. Choudhury (2004)
J. Biol. Chem. 279, 15258-15268
   Abstract »    Full Text »    PDF »
Protein Tyrosine Phosphatase-1B Dephosphorylation of the Insulin Receptor Occurs in a Perinuclear Endosome Compartment in Human Embryonic Kidney 293 Cells.
Y. Romsicki, M. Reece, J.-Y. Gauthier, E. Asante-Appiah, and B. P. Kennedy (2004)
J. Biol. Chem. 279, 12868-12875
   Abstract »    Full Text »    PDF »
Site-Selective Regulation of Platelet-Derived Growth Factor {beta} Receptor Tyrosine Phosphorylation by T-Cell Protein Tyrosine Phosphatase.
C. Persson, C. Savenhed, A. Bourdeau, M. L. Tremblay, B. Markova, F. D. Bohmer, F. G. Haj, B. G. Neel, A. Elson, C.-H. Heldin, et al. (2004)
Mol. Cell. Biol. 24, 2190-2201
   Abstract »    Full Text »    PDF »
The role of protein tyrosine phosphatase 1B in Ras signaling.
N. Dube, A. Cheng, and M. L. Tremblay (2004)
PNAS 101, 1834-1839
   Abstract »    Full Text »    PDF »
Islet-Sparing Effects of Protein Tyrosine Phosphatase-1b Deficiency Delays Onset of Diabetes in IRS2 Knockout Mice.
J. A. Kushner, F. G. Haj, L. D. Klaman, M. A. Dow, B. B. Kahn, B. G. Neel, and M. F. White (2004)
Diabetes 53, 61-66
   Abstract »    Full Text »    PDF »
Insulin Signaling in Health and Disease.
M. F. White (2003)
Science 302, 1710-1711
   Abstract »    Full Text »    PDF »
The Angiotensin II Type I Receptor-associated Protein, ATRAP, Is a Transmembrane Protein and a Modulator of Angiotensin II Signaling.
M. Lopez-Ilasaca, X. Liu, K. Tamura, and V. J. Dzau (2003)
Mol. Biol. Cell 14, 5038-5050
   Abstract »    Full Text »    PDF »
YXXM Motifs in the PDGF-{beta} Receptor Serve Dual Roles as Phosphoinositide 3-Kinase Binding Motifs and Tyrosine-based Endocytic Sorting Signals.
H. Wu, D. A. Windmiller, L. Wang, and J. M. Backer (2003)
J. Biol. Chem. 278, 40425-40428
   Abstract »    Full Text »    PDF »
Protein-tyrosine Phosphatase 1B Mediates the Effects of Insulin on the Actin Cytoskeleton in Immortalized Fibroblasts.
S. Dadke and J. Chernoff (2003)
J. Biol. Chem. 278, 40607-40611
   Abstract »    Full Text »    PDF »
The Src Homology 2 Domain of Rin1 Mediates Its Binding to the Epidermal Growth Factor Receptor and Regulates Receptor Endocytosis.
M. A. Barbieri, C. Kong, P.-I Chen, B. F. Horazdovsky, and P. D. Stahl (2003)
J. Biol. Chem. 278, 32027-32036
   Abstract »    Full Text »    PDF »
Protein Tyrosine Phosphatase 1B Attenuates Growth Hormone-Mediated JAK2-STAT Signaling.
F. Gu, N. Dube, J. W. Kim, A. Cheng, M. d. J. Ibarra-Sanchez, M. L. Tremblay, and Y. R. Boisclair (2003)
Mol. Cell. Biol. 23, 3753-3762
   Abstract »    Full Text »    PDF »
Structure and Ubiquitin Interactions of the Conserved Zinc Finger Domain of Npl4.
B. Wang, S. L. Alam, H. H. Meyer, M. Payne, T. L. Stemmler, D. R. Davis, and W. I. Sundquist (2003)
J. Biol. Chem. 278, 20225-20234
   Abstract »    Full Text »    PDF »
Protein tyrosine phosphatases: the quest for negative regulators of insulin action.
E. Asante-Appiah and B. P. Kennedy (2003)
Am J Physiol Endocrinol Metab 284, E663-E670
   Abstract »    Full Text »    PDF »
Regulation of Insulin Receptor Signaling by the Protein Tyrosine Phosphatase TCPTP.
S. Galic, M. Klingler-Hoffmann, M. T. Fodero-Tavoletti, M. A. Puryer, T.-C. Meng, N. K. Tonks, and T. Tiganis (2003)
Mol. Cell. Biol. 23, 2096-2108
   Abstract »    Full Text »    PDF »
Regulation of Receptor Tyrosine Kinase Signaling by Protein Tyrosine Phosphatase-1B.
F. G. Haj, B. Markova, L. D. Klaman, F. D. Bohmer, and B. G. Neel (2003)
J. Biol. Chem. 278, 739-744
   Abstract »    Full Text »    PDF »
Protein-tyrosine-phosphatase 1B activation is regulated developmentally in muscle of neonatal pigs.
A. Suryawan and T. A. Davis (2003)
Am J Physiol Endocrinol Metab 284, E47-E54
   Abstract »    Full Text »    PDF »
The Arabidopsis kinase-associated protein phosphatase controls internalization of the somatic embryogenesis receptor kinase 1.
K. Shah, E. Russinova, T. W.J. Gadella Jr., J. Willemse, and S. C. de Vries (2002)
Genes & Dev. 16, 1707-1720
   Abstract »    Full Text »    PDF »
A trip to the ER.
N. LeBrasseur (2002)
J. Cell Biol. 156, 940-941
   Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882