Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Science 295 (5562): 2073-2076

Copyright © 2002 by the American Association for the Advancement of Science

The RAR1 Interactor SGT1, an Essential Component of R Gene-Triggered Disease Resistance

Cristina Azevedo,1* Ari Sadanandom,1* Katsumi Kitagawa,2 Andreas Freialdenhoven,3 Ken Shirasu,1dagger Paul Schulze-Lefert13

Plant disease resistance (R) genes trigger innate immune responses upon pathogen attack. RAR1 is an early convergence point in a signaling pathway engaged by multiple R genes. Here, we show that RAR1 interacts with plant orthologs of the yeast protein SGT1, an essential regulator in the cell cycle. Silencing the barley gene Sgt1 reveals its role in R gene-triggered, Rar1-dependent disease resistance. SGT1 associates with SKP1 and CUL1, subunits of the SCF (Skp1-Cullin-F-box) ubiquitin ligase complex. Furthermore, the RAR1-SGT1 complex also interacts with two COP9 signalosome components. The interactions among RAR1, SGT1, SCF, and signalosome subunits indicate a link between disease resistance and ubiquitination.

1 The Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK.
2 Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105-2794, USA.
3 Max-Planck-Institut für Züchtungsforschung, Abteilung Biochemie, Carl-von-Linne-Weg 10, D-50829 Köln, Germany.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: ken.shirasu{at}bbsrc.ac.uk



THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Profile of Paul Schulze-Lefert.
S. Ravindran (2014)
PNAS 111, 570-572
   Full Text »    PDF »
Plant Immune Responses Against Viruses: How Does a Virus Cause Disease?.
K. K. Mandadi and K.-B. G. Scholthof (2013)
PLANT CELL 25, 1489-1505
   Abstract »    Full Text »    PDF »
Dynamic Nucleotide-dependent Interactions of Cysteine- and Histidine-rich Domain (CHORD)-containing Hsp90 Cochaperones Chp-1 and Melusin with Cochaperones PP5 and Sgt1.
T.-J. Hong, S. Kim, A. R. Wi, P. Lee, M. Kang, J.-H. Jeong, and J.-S. Hahn (2013)
J. Biol. Chem. 288, 215-222
   Abstract »    Full Text »    PDF »
Scrib regulates HGF-mediated epithelial morphogenesis and is stabilized by Sgt1-HSP90.
D. J. Eastburn, M. M. Zegers, and K. E. Mostov (2012)
J. Cell Sci. 125, 4147-4157
   Abstract »    Full Text »    PDF »
Ubiquitination during Plant Immune Signaling.
D. Marino, N. Peeters, and S. Rivas (2012)
Plant Physiology 160, 15-27
   Full Text »    PDF »
The U-Box E3 Ligase SPL11/PUB13 Is a Convergence Point of Defense and Flowering Signaling in Plants.
J. Liu, W. Li, Y. Ning, G. Shirsekar, Y. Cai, X. Wang, L. Dai, Z. Wang, W. Liu, and G.-L. Wang (2012)
Plant Physiology 160, 28-37
   Full Text »    PDF »
Stability of plant immune-receptor resistance proteins is controlled by SKP1-CULLIN1-F-box (SCF)-mediated protein degradation.
Y. T. Cheng, Y. Li, S. Huang, Y. Huang, X. Dong, Y. Zhang, and X. Li (2011)
PNAS 108, 14694-14699
   Abstract »    Full Text »    PDF »
Plant homologue constitutive photomorphogenesis 9 (COP9) signalosome subunit CSN5 regulates innate immune responses in macrophages.
Z. Deng, R. Pardi, W. Cheadle, X. Xiang, S. Zhang, S. V. Shah, W. Grizzle, D. Miller, J. Mountz, and H.-G. Zhang (2011)
Blood 117, 4796-4804
   Abstract »    Full Text »    PDF »
Arabidopsis NDR1 Is an Integrin-Like Protein with a Role in Fluid Loss and Plasma Membrane-Cell Wall Adhesion.
C. Knepper, E. A. Savory, and B. Day (2011)
Plant Physiology 156, 286-300
   Abstract »    Full Text »    PDF »
Identification of EMS-Induced Causal Mutations in a Non-Reference Arabidopsis thaliana Accession by Whole Genome Sequencing.
N. Uchida, T. Sakamoto, T. Kurata, and M. Tasaka (2011)
Plant Cell Physiol. 52, 716-722
   Abstract »    Full Text »    PDF »
The PP2A Regulatory Subunit Tap46, a Component of the TOR Signaling Pathway, Modulates Growth and Metabolism in Plants.
C. S. Ahn, J.-A. Han, H.-S. Lee, S. Lee, and H.-S. Pai (2011)
PLANT CELL 23, 185-209
   Abstract »    Full Text »    PDF »
Nucleocytoplasmic Distribution Is Required for Activation of Resistance by the Potato NB-LRR Receptor Rx1 and Is Balanced by Its Functional Domains.
E. Slootweg, J. Roosien, L. N. Spiridon, A.-J. Petrescu, W. Tameling, M. Joosten, R. Pomp, C. van Schaik, R. Dees, J. W. Borst, et al. (2010)
PLANT CELL 22, 4195-4215
   Abstract »    Full Text »    PDF »
Endosome-Associated CRT1 Functions Early in Resistance Gene-Mediated Defense Signaling in Arabidopsis and Tobacco.
H. G. Kang, C. S. Oh, M. Sato, F. Katagiri, J. Glazebrook, H. Takahashi, P. Kachroo, G. B. Martin, and D. F. Klessig (2010)
PLANT CELL 22, 918-936
   Abstract »    Full Text »    PDF »
A novel membrane fusion-mediated plant immunity against bacterial pathogens.
N. Hatsugai, S. Iwasaki, K. Tamura, M. Kondo, K. Fuji, K. Ogasawara, M. Nishimura, and I. Hara-Nishimura (2009)
Genes & Dev. 23, 2496-2506
   Abstract »    Full Text »    PDF »
The Nematode Resistance Allele at the rhg1 Locus Alters the Proteome and Primary Metabolism of Soybean Roots.
A. J. Afzal, A. Natarajan, N. Saini, M. J. Iqbal, M. Geisler, H. A. El Shemy, R. Mungur, L. Willmitzer, and D. A. Lightfoot (2009)
Plant Physiology 151, 1264-1280
   Abstract »    Full Text »    PDF »
In Planta Expression Screens of Phytophthora infestans RXLR Effectors Reveal Diverse Phenotypes, Including Activation of the Solanum bulbocastanum Disease Resistance Protein Rpi-blb2.
S.-K. Oh, C. Young, M. Lee, R. Oliva, T. O. Bozkurt, L. M. Cano, J. Win, J. I.B. Bos, H.-Y. Liu, M. van Damme, et al. (2009)
PLANT CELL 21, 2928-2947
   Abstract »    Full Text »    PDF »
Sgt1 Dimerization Is Negatively Regulated by Protein Kinase CK2-mediated Phosphorylation at Ser361.
P. K. Bansal, A. Mishra, A. A. High, R. Abdulle, and K. Kitagawa (2009)
J. Biol. Chem. 284, 18692-18698
   Abstract »    Full Text »    PDF »
E3 ubiquitin ligases and plant innate immunity.
A. Craig, R. Ewan, J. Mesmar, V. Gudipati, and A. Sadanandom (2009)
J. Exp. Bot.
   Abstract »    Full Text »    PDF »
Sgt1 Dimerization Is Required for Yeast Kinetochore Assembly.
P. K. Bansal, A. Nourse, R. Abdulle, and K. Kitagawa (2009)
J. Biol. Chem. 284, 3586-3592
   Abstract »    Full Text »    PDF »
A stress protein interface of innate immunity.
D. Picard (2008)
EMBO Rep. 9, 1193-1195
   Full Text »    PDF »
Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes.
M. Zhang, M. Boter, K. Li, Y. Kadota, B. Panaretou, C. Prodromou, K. Shirasu, and L. H. Pearl (2008)
EMBO J. 27, 2789-2798
   Abstract »    Full Text »    PDF »
The Arabidopsis COP9 Signalosome Subunit 7 Is a Model PCI Domain Protein with Subdomains Involved in COP9 Signalosome Assembly.
M. Dessau, Y. Halimi, T. Erez, O. Chomsky-Hecht, D. A. Chamovitz, and J. A. Hirsch (2008)
PLANT CELL 20, 2815-2834
   Abstract »    Full Text »    PDF »
Combination of Novel Green Fluorescent Protein Mutant TSapphire and DsRed Variant mOrange to Set Up a Versatile in Planta FRET-FLIM Assay.
V. Bayle, L. Nussaume, and R. A. Bhat (2008)
Plant Physiology 148, 51-60
   Abstract »    Full Text »    PDF »
RACK1 Functions in Rice Innate Immunity by Interacting with the Rac1 Immune Complex.
A. Nakashima, L. Chen, N. P. Thao, M. Fujiwara, H. L. Wong, M. Kuwano, K. Umemura, K. Shirasu, T. Kawasaki, and K. Shimamoto (2008)
PLANT CELL 20, 2265-2279
   Abstract »    Full Text »    PDF »
Repression of the Auxin Response Pathway Increases Arabidopsis Susceptibility to Necrotrophic Fungi.
F. Llorente, P. Muskett, A. Sanchez-Vallet, G. Lopez, B. Ramos, C. Sanchez-Rodriguez, L. Jorda, J. Parker, and A. Molina (2008)
Mol Plant 1, 496-509
   Abstract »    Full Text »    PDF »
The hypersensitive response; the centenary is upon us but how much do we know?.
L. A. J. Mur, P. Kenton, A. J. Lloyd, H. Ougham, and E. Prats (2008)
J. Exp. Bot. 59, 501-520
   Abstract »    Full Text »    PDF »
Interaction between SGT1 and Cytosolic/Nuclear HSC70 Chaperones Regulates Arabidopsis Immune Responses.
L. D. Noel, G. Cagna, J. Stuttmann, L. Wirthmuller, S. Betsuyaku, C.-P. Witte, R. Bhat, N. Pochon, T. Colby, and J. E. Parker (2007)
PLANT CELL 19, 4061-4076
   Abstract »    Full Text »    PDF »
RAR1 and HSP90 Form a Complex with Rac/Rop GTPase and Function in Innate-Immune Responses in Rice.
N. P. Thao, L. Chen, A. Nakashima, S.-i. Hara, K. Umemura, A. Takahashi, K. Shirasu, T. Kawasaki, and K. Shimamoto (2007)
PLANT CELL 19, 4035-4045
   Abstract »    Full Text »    PDF »
Induction of a Small Heat Shock Protein and Its Functional Roles in Nicotiana Plants in the Defense Response against Ralstonia solanacearum.
M. Maimbo, K. Ohnishi, Y. Hikichi, H. Yoshioka, and A. Kiba (2007)
Plant Physiology 145, 1588-1599
   Abstract »    Full Text »    PDF »
Structural and Functional Analysis of SGT1 Reveals That Its Interaction with HSP90 Is Required for the Accumulation of Rx, an R Protein Involved in Plant Immunity.
M. Boter, B. Amigues, J. Peart, C. Breuer, Y. Kadota, C. Casais, G. Moore, C. Kleanthous, F. Ochsenbein, K. Shirasu, et al. (2007)
PLANT CELL 19, 3791-3804
   Abstract »    Full Text »    PDF »
Rumble in the nuclear jungle: compartmentalization, trafficking, and nuclear action of plant immune receptors.
Q.-H. Shen and P. Schulze-Lefert (2007)
EMBO J. 26, 4293-4301
   Abstract »    Full Text »    PDF »
Rice Pti1a Negatively Regulates RAR1-Dependent Defense Responses.
A. Takahashi, G. K. Agrawal, M. Yamazaki, K. Onosato, A. Miyao, T. Kawasaki, K. Shimamoto, and H. Hirochika (2007)
PLANT CELL 19, 2940-2951
   Abstract »    Full Text »    PDF »
The Arabidopsis BAP1 and BAP2 Genes Are General Inhibitors of Programmed Cell Death.
H. Yang, S. Yang, Y. Li, and J. Hua (2007)
Plant Physiology 145, 135-146
   Abstract »    Full Text »    PDF »
Regulation of plant innate immunity by three proteins in a complex conserved across the plant and animal kingdoms.
K. Palma, Q. Zhao, Y. T. Cheng, D. Bi, J. Monaghan, W. Cheng, Y. Zhang, and X. Li (2007)
Genes & Dev. 21, 1484-1493
   Abstract »    Full Text »    PDF »
Barley MLO Modulates Actin-Dependent and Actin-Independent Antifungal Defense Pathways at the Cell Periphery.
M. Miklis, C. Consonni, R. A. Bhat, V. Lipka, P. Schulze-Lefert, and R. Panstruga (2007)
Plant Physiology 144, 1132-1143
   Abstract »    Full Text »    PDF »
Ubiquitin, Hormones and Biotic Stress in Plants.
K. Dreher and J. Callis (2007)
Ann. Bot. 99, 787-822
   Abstract »    Full Text »    PDF »
The Mi-1-Mediated Pest Resistance Requires Hsp90 and Sgt1.
K. K. Bhattarai, Q. Li, Y. Liu, S. P. Dinesh-Kumar, and I. Kaloshian (2007)
Plant Physiology 144, 312-323
   Abstract »    Full Text »    PDF »
The Subunit CSN6 of the COP9 Signalosome Is Cleaved during Apoptosis.
J. d. S. Correia, Y. Miranda, N. Leonard, and R. J. Ulevitch (2007)
J. Biol. Chem. 282, 12557-12565
   Abstract »    Full Text »    PDF »
SGT1 is essential for Nod1 activation.
J. da Silva Correia, Y. Miranda, N. Leonard, and R. Ulevitch (2007)
PNAS 104, 6764-6769
   Abstract »    Full Text »    PDF »
A Proteasome-regulated Glycogen Synthase Kinase-3 Modulates Disease Response in Plants.
M. Wrzaczek, W. Rozhon, and C. Jonak (2007)
J. Biol. Chem. 282, 5249-5255
   Abstract »    Full Text »    PDF »
MEKK1 Is Required for MPK4 Activation and Regulates Tissue-specific and Temperature-dependent Cell Death in Arabidopsis.
K. Ichimura, C. Casais, S. C. Peck, K. Shinozaki, and K. Shirasu (2006)
J. Biol. Chem. 281, 36969-36976
   Abstract »    Full Text »    PDF »
Rice XA21 Binding Protein 3 Is a Ubiquitin Ligase Required for Full Xa21-Mediated Disease Resistance.
Y.-S. Wang, L.-Y. Pi, X. Chen, P. K. Chakrabarty, J. Jiang, A. L. De Leon, G.-Z. Liu, L. Li, U. Benny, J. Oard, et al. (2006)
PLANT CELL 18, 3635-3646
   Abstract »    Full Text »    PDF »
Phytotoxicity and Innate Immune Responses Induced by Nep1-Like Proteins.
D. Qutob, B. Kemmerling, F. Brunner, I. Kufner, S. Engelhardt, A. A. Gust, B. Luberacki, H. U. Seitz, D. Stahl, T. Rauhut, et al. (2006)
PLANT CELL 18, 3721-3744
   Abstract »    Full Text »    PDF »
Sgt1p Is a Unique Co-chaperone That Acts as a Client Adaptor to Link Hsp90 to Skp1p.
M. G. Catlett and K. B. Kaplan (2006)
J. Biol. Chem. 281, 33739-33748
   Abstract »    Full Text »    PDF »
Protein Polyubiquitination Plays a Role in Basal Host Resistance of Barley.
W. Dong, D. Nowara, and P. Schweizer (2006)
PLANT CELL 18, 3321-3331
   Abstract »    Full Text »    PDF »
Mitochondria-Associated Hexokinases Play a Role in the Control of Programmed Cell Death in Nicotiana benthamiana.
M. Kim, J.-H. Lim, C. S. Ahn, K. Park, G. T. Kim, W. T. Kim, and H.-S. Pai (2006)
PLANT CELL 18, 2341-2355
   Abstract »    Full Text »    PDF »
Regulatory Mechanisms of ROI Generation are Affected by Rice spl Mutations.
K. Kojo, T. Yaeno, K. Kusumi, H. Matsumura, S. Fujisawa, R. Terauchi, and K. Iba (2006)
Plant Cell Physiol. 47, 1035-1044
   Abstract »    Full Text »    PDF »
Role of SGT1 in resistance protein accumulation in plant immunity.
C. Azevedo, S. Betsuyaku, J. Peart, A. Takahashi, L. Noel, A. Sadanandom, C. Casais, J. Parker, and K. Shirasu (2006)
EMBO J. 25, 2007-2016
   Abstract »    Full Text »    PDF »
The U-Box Protein CMPG1 Is Required for Efficient Activation of Defense Mechanisms Triggered by Multiple Resistance Genes in Tobacco and Tomato.
R. Gonzalez-Lamothe, D. I. Tsitsigiannis, A. A. Ludwig, M. Panicot, K. Shirasu, and J. D.G. Jones (2006)
PLANT CELL 18, 1067-1083
   Abstract »    Full Text »    PDF »
Inactivation of Organellar Glutamyl- and Seryl-tRNA Synthetases Leads to Developmental Arrest of Chloroplasts and Mitochondria in Higher Plants.
Y.-K. Kim, J.-Y. Lee, H. S. Cho, S. S. Lee, H. J. Ha, S. Kim, D. Choi, and H.-S. Pai (2005)
J. Biol. Chem. 280, 37098-37106
   Abstract »    Full Text »    PDF »
Cutting Edge: Bacterial Modulation of Epithelial Signaling via Changes in Neddylation of Cullin-1.
L. S. Collier-Hyams, V. Sloane, B. C. Batten, and A. S. Neish (2005)
J. Immunol. 175, 4194-4198
   Abstract »    Full Text »    PDF »
Antagonistic Control of Disease Resistance Protein Stability in the Plant Immune System.
B. F. Holt III, Y. Belkhadir, and J. L. Dangl (2005)
Science 309, 929-932
   Abstract »    Full Text »    PDF »
RNA Silencing of Single and Multiple Members in a Gene Family of Rice.
D. Miki, R. Itoh, and K. Shimamoto (2005)
Plant Physiology 138, 1903-1913
   Abstract »    Full Text »    PDF »
Development of a Virus-Induced Gene-Silencing System for Hexaploid Wheat and Its Use in Functional Analysis of the Lr21-Mediated Leaf Rust Resistance Pathway.
S. R. Scofield, L. Huang, A. S. Brandt, and B. S. Gill (2005)
Plant Physiology 138, 2165-2173
   Abstract »    Full Text »    PDF »
Virus-Induced Gene Silencing-Based Functional Characterization of Genes Associated with Powdery Mildew Resistance in Barley.
I. Hein, M. Barciszewska-Pacak, K. Hrubikova, S. Williamson, M. Dinesen, I. E. Soenderby, S. Sundar, A. Jarmolowski, K. Shirasu, and C. Lacomme (2005)
Plant Physiology 138, 2155-2164
   Abstract »    Full Text »    PDF »
Molecular Genetic Evidence for the Role of SGT1 in the Intramolecular Complementation of Bs2 Protein Activity in Nicotiana benthamiana.
R. T. Leister, D. Dahlbeck, B. Day, Y. Li, O. Chesnokova, and B. J. Staskawicz (2005)
PLANT CELL 17, 1268-1278
   Abstract »    Full Text »    PDF »
A Putative Nucleoporin 96 Is Required for Both Basal Defense and Constitutive Resistance Responses Mediated by suppressor of npr1-1,constitutive 1.
Y. Zhang and X. Li (2005)
PLANT CELL 17, 1306-1316
   Abstract »    Full Text »    PDF »
Molecular Genetics of Disease Resistance in Cereals.
M. A. AYLIFFE and E. S. LAGUDAH (2004)
Ann. Bot. 94, 765-773
   Abstract »    Full Text »    PDF »
RAR1 Positively Controls Steady State Levels of Barley MLA Resistance Proteins and Enables Sufficient MLA6 Accumulation for Effective Resistance.
S. Bieri, S. Mauch, Q.-H. Shen, J. Peart, A. Devoto, C. Casais, F. Ceron, S. Schulze, H.-H. Steinbiss, K. Shirasu, et al. (2004)
PLANT CELL 16, 3480-3495
   Abstract »    Full Text »    PDF »
The Interaction between Sgt1p and Skp1p Is Regulated by HSP90 Chaperones and Is Required for Proper CBF3 Assembly.
L. B. Lingelbach and K. B. Kaplan (2004)
Mol. Cell. Biol. 24, 8938-8950
   Abstract »    Full Text »    PDF »
Arabidopsis RIN4 Negatively Regulates Disease Resistance Mediated by RPS2 and RPM1 Downstream or Independent of the NDR1 Signal Modulator and Is Not Required for the Virulence Functions of Bacterial Type III Effectors AvrRpt2 or AvrRpm1.
Y. Belkhadir, Z. Nimchuk, D. A. Hubert, D. Mackey, and J. L. Dangl (2004)
PLANT CELL 16, 2822-2835
   Abstract »    Full Text »    PDF »
Spotted leaf11, a Negative Regulator of Plant Cell Death and Defense, Encodes a U-Box/Armadillo Repeat Protein Endowed with E3 Ubiquitin Ligase Activity.
L.-R. Zeng, S. Qu, A. Bordeos, C. Yang, M. Baraoidan, H. Yan, Q. Xie, B. H. Nahm, H. Leung, and G.-L. Wang (2004)
PLANT CELL 16, 2795-2808
   Abstract »    Full Text »    PDF »
Sgt1 Associates with Hsp90: an Initial Step of Assembly of the Core Kinetochore Complex.
P. K. Bansal, R. Abdulle, and K. Kitagawa (2004)
Mol. Cell. Biol. 24, 8069-8079
   Abstract »    Full Text »    PDF »
Cutting Edge Transcriptome Analysis: It's All about Design.
N. A. Eckardt (2004)
PLANT CELL 16, 2249-2251
   Full Text »    PDF »
Interaction-Dependent Gene Expression in Mla-Specified Response to Barley Powdery Mildew.
R. A. Caldo, D. Nettleton, and R. P. Wise (2004)
PLANT CELL 16, 2514-2528
   Abstract »    Full Text »    PDF »
CHPA, a Cysteine- and Histidine-Rich-Domain-Containing Protein, Contributes to Maintenance of the Diploid State in Aspergillus nidulans.
A. Sadanandom, K. Findlay, J. H. Doonan, P. Schulze-Lefert, and K. Shirasu (2004)
Eukaryot. Cell 3, 984-991
   Abstract »    Full Text »    PDF »
VASCULAR ASSOCIATED DEATH1, a Novel GRAM Domain-Containing Protein, Is a Regulator of Cell Death and Defense Responses in Vascular Tissues.
S. Lorrain, B. Lin, M. C. Auriac, T. Kroj, P. Saindrenan, M. Nicole, C. Balague, and D. Roby (2004)
PLANT CELL 16, 2217-2232
   Abstract »    Full Text »    PDF »
Isolation and Gene Expression Analysis of Arabidopsis thaliana Mutants With Constitutive Expression of ATL2, an Early Elicitor-Response RING-H2 Zinc-Finger Gene.
M. Serrano and P. Guzman (2004)
Genetics 167, 919-929
   Abstract »    Full Text »    PDF »
Guarding the Goods. New Insights into the Central Alarm System of Plants.
R. W. Innes (2004)
Plant Physiology 135, 695-701
   Full Text »    PDF »
Gene Expression Signatures from Three Genetically Separable Resistance Gene Signaling Pathways for Downy Mildew Resistance.
T. Eulgem, V. J. Weigman, H.-S. Chang, J. M. McDowell, E. B. Holub, J. Glazebrook, T. Zhu, and J. L. Dangl (2004)
Plant Physiology 135, 1129-1144
   Abstract »    Full Text »    PDF »
The Transcriptional Innate Immune Response to flg22. Interplay and Overlap with Avr Gene-Dependent Defense Responses and Bacterial Pathogenesis.
L. Navarro, C. Zipfel, O. Rowland, I. Keller, S. Robatzek, T. Boller, and J. D.G. Jones (2004)
Plant Physiology 135, 1113-1128
   Abstract »    Full Text »    PDF »
Human Sgt1 Binds HSP90 through the CHORD-Sgt1 Domain and Not the Tetratricopeptide Repeat Domain.
Y.-T. Lee, J. Jacob, W. Michowski, M. Nowotny, J. Kuznicki, and W. J. Chazin (2004)
J. Biol. Chem. 279, 16511-16517
   Abstract »    Full Text »    PDF »
Simple RNAi Vectors for Stable and Transient Suppression of Gene Function in Rice.
D. Miki and K. Shimamoto (2004)
Plant Cell Physiol. 45, 490-495
   Abstract »    Full Text »    PDF »
A Haplotype-Specific Resistance Gene Regulated by BONZAI1 Mediates Temperature-Dependent Growth Control in Arabidopsis.
S. Yang and J. Hua (2004)
PLANT CELL 16, 1060-1071
   Abstract »    Full Text »    PDF »
Molecular Chaperone Hsp90 Associates with Resistance Protein N and Its Signaling Proteins SGT1 and Rar1 to Modulate an Innate Immune Response in Plants.
Y. Liu, T. Burch-Smith, M. Schiff, S. Feng, and S. P. Dinesh-Kumar (2004)
J. Biol. Chem. 279, 2101-2108
   Abstract »    Full Text »    PDF »
Cytosolic HSP90 associates with and modulates the Arabidopsis RPM1 disease resistance protein.
D. A. Hubert, P. Tornero, Y. Belkhadir, P. Krishna, A. Takahashi, K. Shirasu, and J. L. Dangl (2003)
EMBO J. 22, 5679-5689
   Abstract »    Full Text »    PDF »
High throughput virus-induced gene silencing implicates heat shock protein 90 in plant disease resistance.
R. Lu, I. Malcuit, P. Moffett, M. T. Ruiz, J. Peart, A.-J. Wu, J. P. Rathjen, A. Bendahmane, L. Day, and D. C. Baulcombe (2003)
EMBO J. 22, 5690-5699
   Abstract »    Full Text »    PDF »
HSP90 interacts with RAR1 and SGT1 and is essential for RPS2-mediated disease resistance in Arabidopsis.
A. Takahashi, C. Casais, K. Ichimura, and K. Shirasu (2003)
PNAS 100, 11777-11782
   Abstract »    Full Text »    PDF »
Cleavage of Arabidopsis PBS1 by a Bacterial Type III Effector.
F. Shao, C. Golstein, J. Ade, M. Stoutemyer, J. E. Dixon, and R. W. Innes (2003)
Science 301, 1230-1233
   Abstract »    Full Text »    PDF »
Overexpression of the Disease Resistance Gene Pto in Tomato Induces Gene Expression Changes Similar to Immune Responses in Human and Fruitfly.
K. S. Mysore, M. D. D'Ascenzo, X. He, and G. B. Martin (2003)
Plant Physiology 132, 1901-1912
   Abstract »    Full Text »    PDF »
Arabidopsis SGT1b Is Required for SCFTIR1-Mediated Auxin Response.
W. M. Gray, P. R. Muskett, H.-w. Chuang, and J. E. Parker (2003)
PLANT CELL 15, 1310-1319
   Abstract »    Full Text »    PDF »
Activation of the Programmed Cell Death Pathway by Inhibition of Proteasome Function in Plants.
M. Kim, J.-W. Ahn, U.-H. Jin, D. Choi, K.-H. Paek, and H.-S. Pai (2003)
J. Biol. Chem. 278, 19406-19415
   Abstract »    Full Text »    PDF »
A network of rice genes associated with stress response and seed development.
B. Cooper, J. D. Clarke, P. Budworth, J. Kreps, D. Hutchison, S. Park, S. Guimil, M. Dunn, P. Luginbuhl, C. Ellero, et al. (2003)
PNAS 100, 4945-4950
   Abstract »    Full Text »    PDF »
Recognition Specificity and RAR1/SGT1 Dependence in Barley Mla Disease Resistance Genes to the Powdery Mildew Fungus.
Q.-H. Shen, F. Zhou, S. Bieri, T. Haizel, K. Shirasu, and P. Schulze-Lefert (2003)
PLANT CELL 15, 732-744
   Abstract »    Full Text »    PDF »
Powdery Mildew-Induced Mla mRNAs Are Alternatively Spliced and Contain Multiple Upstream Open Reading Frames.
D. A. Halterman, F. Wei, and R. P. Wise (2003)
Plant Physiology 131, 558-567
   Abstract »    Full Text »    PDF »
2002: Signaling Breakthroughs of the Year.
E. M. Adler, N. R. Gough, and L. B. Ray (2003)
Sci. STKE 2003, eg1
   Full Text »    PDF »
Identification and Characterization of the ARIADNE Gene Family in Arabidopsis. A Group of Putative E3 Ligases.
C. Mladek, K. Guger, and M.-T. Hauser (2003)
Plant Physiology 131, 27-40
   Abstract »    Full Text »    PDF »
Diversity in Nucleotide Binding Site-Leucine-Rich Repeat Genes in Cereals.
J. Bai, L. A. Pennill, J. Ning, S. W. Lee, J. Ramalingam, C. A. Webb, B. Zhao, Q. Sun, J. C. Nelson, J. E. Leach, et al. (2002)
Genome Res. 12, 1871-1884
   Abstract »    Full Text »    PDF »
Gibberellin-Mediated Proteasome-Dependent Degradation of the Barley DELLA Protein SLN1 Repressor.
X. Fu, D. E. Richards, T. Ait-ali, L. W. Hynes, H. Ougham, J. Peng, and N. P. Harberd (2002)
PLANT CELL 14, 3191-3200
   Abstract »    Full Text »    PDF »
Phytochrome-mediated photoperception and signal transduction in higher plants.
E. Schafer and C. Bowler (2002)
EMBO Rep. 3, 1042-1048
   Abstract »    Full Text »    PDF »
Interaction between domains of a plant NBS-LRR protein in disease resistance-related cell death.
P. Moffett, G. Farnham, J. Peart, and D. C. Baulcombe (2002)
EMBO J. 21, 4511-4519
   Abstract »    Full Text »    PDF »
Arabidopsis Research Heats Up in Seville.
D. Alabadi, A. Devoto, and N. A. Eckardt (2002)
PLANT CELL 14, 1987-1994
   Full Text »    PDF »
Ubiquitin ligase-associated protein SGT1 is required for host and nonhost disease resistance in plants.
J. R. Peart, R. Lu, A. Sadanandom, I. Malcuit, P. Moffett, D. C. Brice, L. Schauser, D. A. W. Jaggard, S. Xiao, M. J. Coleman, et al. (2002)
PNAS 99, 10865-10869
   Abstract »    Full Text »    PDF »
Schizosaccharomyces pombe Git7p, a Member of the Saccharomyces cerevisiae Sgt1p Family, Is Required for Glucose and Cyclic AMP Signaling, Cell Wall Integrity, and Septation.
K. Schadick, H. M. Fourcade, P. Boumenot, J. J. Seitz, J. L. Morrell, L. Chang, K. L. Gould, J. F. Partridge, R. C. Allshire, K. Kitagawa, et al. (2002)
Eukaryot. Cell 1, 558-567
   Abstract »    Full Text »    PDF »
Genome Dynamics and Evolution of the Mla (Powdery Mildew) Resistance Locus in Barley.
F. Wei, R. A. Wing, and R. P. Wise (2002)
PLANT CELL 14, 1903-1917
   Abstract »    Full Text »    PDF »
Role of SCF Ubiquitin-Ligase and the COP9 Signalosome in the N Gene-Mediated Resistance Response to Tobacco mosaic virus.
Y. Liu, M. Schiff, G. Serino, X.-W. Deng, and S. P. Dinesh-Kumar (2002)
PLANT CELL 14, 1483-1496
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882