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Science 295 (5562): 2073-2076

Copyright © 2002 by the American Association for the Advancement of Science

The RAR1 Interactor SGT1, an Essential Component of R Gene-Triggered Disease Resistance

Cristina Azevedo,1* Ari Sadanandom,1* Katsumi Kitagawa,2 Andreas Freialdenhoven,3 Ken Shirasu,1dagger Paul Schulze-Lefert13

Plant disease resistance (R) genes trigger innate immune responses upon pathogen attack. RAR1 is an early convergence point in a signaling pathway engaged by multiple R genes. Here, we show that RAR1 interacts with plant orthologs of the yeast protein SGT1, an essential regulator in the cell cycle. Silencing the barley gene Sgt1 reveals its role in R gene-triggered, Rar1-dependent disease resistance. SGT1 associates with SKP1 and CUL1, subunits of the SCF (Skp1-Cullin-F-box) ubiquitin ligase complex. Furthermore, the RAR1-SGT1 complex also interacts with two COP9 signalosome components. The interactions among RAR1, SGT1, SCF, and signalosome subunits indicate a link between disease resistance and ubiquitination.

1 The Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK.
2 Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105-2794, USA.
3 Max-Planck-Institut für Züchtungsforschung, Abteilung Biochemie, Carl-von-Linne-Weg 10, D-50829 Köln, Germany.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: ken.shirasu{at}bbsrc.ac.uk

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K. Schadick, H. M. Fourcade, P. Boumenot, J. J. Seitz, J. L. Morrell, L. Chang, K. L. Gould, J. F. Partridge, R. C. Allshire, K. Kitagawa, et al. (2002)
Eukaryot. Cell 1, 558-567
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Genome Dynamics and Evolution of the Mla (Powdery Mildew) Resistance Locus in Barley.
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PLANT CELL 14, 1903-1917
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Role of SCF Ubiquitin-Ligase and the COP9 Signalosome in the N Gene-Mediated Resistance Response to Tobacco mosaic virus.
Y. Liu, M. Schiff, G. Serino, X.-W. Deng, and S. P. Dinesh-Kumar (2002)
PLANT CELL 14, 1483-1496
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Two immediate-early pathogen-responsive members of the AtCMPG gene family in Arabidopsis thaliana and the W-box-containing elicitor-response element of AtCMPG1.
A. Heise, B. Lippok, C. Kirsch, and K. Hahlbrock (2002)
PNAS 99, 9049-9054
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Arabidopsis RAR1 Exerts Rate-Limiting Control of R Gene-Mediated Defenses against Multiple Pathogens.
P. R. Muskett, K. Kahn, M. J. Austin, L. J. Moisan, A. Sadanandom, K. Shirasu, J. D. G. Jones, and J. E. Parker (2002)
PLANT CELL 14, 979-992
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Arabidopsis SGT1b Is Required for Defense Signaling Conferred by Several Downy Mildew Resistance Genes.
M. Tor, P. Gordon, A. Cuzick, T. Eulgem, E. Sinapidou, F. Mert-Turk, C. Can, J. L. Dangl, and E. B. Holub (2002)
PLANT CELL 14, 993-1003
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A Breakdown in Defense Signaling.
P. N. Dodds and C. Schwechheimer (2002)
PLANT CELL 14, S5-S8
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PLANT BIOLOGY: Enhanced: Resisting Attack.
M. Nishimura and S. Somerville (2002)
Science 295, 2032-2033
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Regulatory Role of SGT1 in Early R Gene-Mediated Plant Defenses.
M. J. Austin, P. Muskett, K. Kahn, B. J. Feys, J. D. G. Jones, and J. E. Parker (2002)
Science 295, 2077-2080
   Abstract »    Full Text »    PDF »

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