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Science 295 (5562): 2073-2076

Copyright © 2002 by the American Association for the Advancement of Science

The RAR1 Interactor SGT1, an Essential Component of R Gene-Triggered Disease Resistance

Cristina Azevedo,1* Ari Sadanandom,1* Katsumi Kitagawa,2 Andreas Freialdenhoven,3 Ken Shirasu,1dagger Paul Schulze-Lefert13

Plant disease resistance (R) genes trigger innate immune responses upon pathogen attack. RAR1 is an early convergence point in a signaling pathway engaged by multiple R genes. Here, we show that RAR1 interacts with plant orthologs of the yeast protein SGT1, an essential regulator in the cell cycle. Silencing the barley gene Sgt1 reveals its role in R gene-triggered, Rar1-dependent disease resistance. SGT1 associates with SKP1 and CUL1, subunits of the SCF (Skp1-Cullin-F-box) ubiquitin ligase complex. Furthermore, the RAR1-SGT1 complex also interacts with two COP9 signalosome components. The interactions among RAR1, SGT1, SCF, and signalosome subunits indicate a link between disease resistance and ubiquitination.

1 The Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK.
2 Department of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105-2794, USA.
3 Max-Planck-Institut für Züchtungsforschung, Abteilung Biochemie, Carl-von-Linne-Weg 10, D-50829 Köln, Germany.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: ken.shirasu{at}

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2002: Signaling Breakthroughs of the Year.
E. M. Adler, N. R. Gough, and L. B. Ray (2003)
Sci. STKE 2003, eg1
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Identification and Characterization of the ARIADNE Gene Family in Arabidopsis. A Group of Putative E3 Ligases.
C. Mladek, K. Guger, and M.-T. Hauser (2003)
Plant Physiology 131, 27-40
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Diversity in Nucleotide Binding Site-Leucine-Rich Repeat Genes in Cereals.
J. Bai, L. A. Pennill, J. Ning, S. W. Lee, J. Ramalingam, C. A. Webb, B. Zhao, Q. Sun, J. C. Nelson, J. E. Leach, et al. (2002)
Genome Res. 12, 1871-1884
   Abstract »    Full Text »    PDF »
Gibberellin-Mediated Proteasome-Dependent Degradation of the Barley DELLA Protein SLN1 Repressor.
X. Fu, D. E. Richards, T. Ait-ali, L. W. Hynes, H. Ougham, J. Peng, and N. P. Harberd (2002)
PLANT CELL 14, 3191-3200
   Abstract »    Full Text »    PDF »
Phytochrome-mediated photoperception and signal transduction in higher plants.
E. Schafer and C. Bowler (2002)
EMBO Rep. 3, 1042-1048
   Abstract »    Full Text »    PDF »
Interaction between domains of a plant NBS-LRR protein in disease resistance-related cell death.
P. Moffett, G. Farnham, J. Peart, and D. C. Baulcombe (2002)
EMBO J. 21, 4511-4519
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Arabidopsis Research Heats Up in Seville.
D. Alabadi, A. Devoto, and N. A. Eckardt (2002)
PLANT CELL 14, 1987-1994
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Ubiquitin ligase-associated protein SGT1 is required for host and nonhost disease resistance in plants.
J. R. Peart, R. Lu, A. Sadanandom, I. Malcuit, P. Moffett, D. C. Brice, L. Schauser, D. A. W. Jaggard, S. Xiao, M. J. Coleman, et al. (2002)
PNAS 99, 10865-10869
   Abstract »    Full Text »    PDF »
Schizosaccharomyces pombe Git7p, a Member of the Saccharomyces cerevisiae Sgt1p Family, Is Required for Glucose and Cyclic AMP Signaling, Cell Wall Integrity, and Septation.
K. Schadick, H. M. Fourcade, P. Boumenot, J. J. Seitz, J. L. Morrell, L. Chang, K. L. Gould, J. F. Partridge, R. C. Allshire, K. Kitagawa, et al. (2002)
Eukaryot. Cell 1, 558-567
   Abstract »    Full Text »    PDF »
Genome Dynamics and Evolution of the Mla (Powdery Mildew) Resistance Locus in Barley.
F. Wei, R. A. Wing, and R. P. Wise (2002)
PLANT CELL 14, 1903-1917
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Role of SCF Ubiquitin-Ligase and the COP9 Signalosome in the N Gene-Mediated Resistance Response to Tobacco mosaic virus.
Y. Liu, M. Schiff, G. Serino, X.-W. Deng, and S. P. Dinesh-Kumar (2002)
PLANT CELL 14, 1483-1496
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