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Science 295 (5562): 2077-2080

Copyright © 2002 by the American Association for the Advancement of Science

Regulatory Role of SGT1 in Early R Gene-Mediated Plant Defenses

Mark J. Austin,1 Paul Muskett,1 Katherine Kahn,1 Bart J. Feys,1 Jonathan D. G. Jones,1 Jane E. Parker12*

Animal SGT1 is a component of Skp1-Cullin-F-box protein (SCF) ubiquitin ligases that target regulatory proteins for degradation. Mutations in one (SGT1b) of two highly homologous Arabidopsis SGT1 genes disable early plant defenses conferred by multiple resistance (R) genes. Loss of SGT1b function in resistance is not compensated for by SGT1a. R genes differ in their requirements for SGT1b and a second resistance signaling gene, RAR1, that was previously implicated as an SGT1 interactor. Moreover, SGT1b and RAR1 contribute additively to RPP5-mediated pathogen recognition. These data imply both operationally distinct and cooperative functions of SGT1 and RAR1 in plant disease resistance.

1 Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK.
2 Max Planck Institute for Plant Breeding Research, Carl-von-Linné Weg 10, D-50829 Cologne, Germany.
*   To whom correspondence should be addressed. E-mail: parker{at}mpiz-koeln.mpg.de

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