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Science 295 (5563): 2276-2279

Copyright © 2002 by the American Association for the Advancement of Science

Neuronal Calcium Sensor 1 and Activity-Dependent Facilitation of P/Q-Type Calcium Currents at Presynaptic Nerve Terminals

Tetsuhiro Tsujimoto,1*dagger Andreas Jeromin,2* Naoto Saitoh,1 John C. Roder,2 Tomoyuki Takahashi1

P/Q-type presynaptic calcium currents (IpCa) undergo activity-dependent facilitation during repetitive activation at the calyx of the Held synapse. We investigated whether neuronal calcium sensor 1 (NCS-1) may underlie this phenomenon. Direct loading of NCS-1 into the nerve terminal mimicked activity-dependent IpCa facilitation by accelerating the activation time of IpCa in a Ca2+-dependent manner. A presynaptically loaded carboxyl-terminal peptide of NCS-1 abolished IpCa facilitation. These results suggest that residual Ca2+ activates endogenous NCS-1, thereby facilitating IpCa. Because both P/Q-type Ca2+ channels and NCS-1 are widely expressed in mammalian nerve terminals, NCS-1 may contribute to the activity-dependent synaptic facilitation at many synapses.

1 Department of Neurophysiology, University of Tokyo Faculty of Medicine, Tokyo 113-0033, Japan.
2 Mount Sinai Hospital Research Institute, Toronto, Ontario M5G 1X5, Canada.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: tujimoto-tky{at}umin.ac.jp



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