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Neuronal Calcium Sensor 1 and Activity-Dependent Facilitation of P/Q-Type Calcium Currents at Presynaptic Nerve Terminals
Tetsuhiro Tsujimoto,1*Andreas Jeromin,2*Naoto Saitoh,1John C. Roder,2Tomoyuki Takahashi1
P/Q-type presynaptic calcium currents
(IpCa) undergo activity-dependent
facilitation during repetitive activation at the calyxof the Held
synapse. We investigated whether neuronal calciumsensor 1 (NCS-1) may
underlie this phenomenon. Direct loadingof NCS-1 into the nerve
terminal mimicked activity-dependent IpCafacilitation by accelerating the activation time of
IpCa in aCa2+-dependent manner. A
presynaptically loaded carboxyl-terminalpeptide of NCS-1 abolished
IpCa facilitation. These results suggestthat
residual Ca2+ activates endogenous NCS-1, thereby
facilitating IpCa. Becauseboth P/Q-type
Ca2+ channels and NCS-1 are widely expressed in mammalian
nerve terminals,NCS-1 may contribute to the activity-dependent
synaptic facilitationat many synapses.
1 Department of Neurophysiology, University of
Tokyo Faculty of Medicine, Tokyo 113-0033, Japan.
2 Mount Sinai Hospital Research Institute, Toronto,
Ontario M5G 1X5, Canada.
*
These authors contributed equally to this work.
To whom correspondence should be addressed. E-mail:
tujimoto-tky{at}umin.ac.jp
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