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Science 296 (5566): 359-362

Copyright © 2002 by the American Association for the Advancement of Science

Requirement for a Peptidoglycan Recognition Protein (PGRP) in Relish Activation and Antibacterial Immune Responses in Drosophila

Kwang-Min Choe,12 Thomas Werner,3 Svenja Stöven,3 Dan Hultmark,3 Kathryn V. Anderson12*

Components of microbial cell walls are potent activators of innate immune responses in animals. For example, the mammalian TLR4 signaling pathway is activated by bacterial lipopolysaccharide and is required for resistance to infection by Gram-negative bacteria. Other components of microbial surfaces, such as peptidoglycan, are also potent activators of innate immune responses, but less is known about how those components activate host defense. Here we show that a peptidoglycan recognition protein, PGRP-LC, is absolutely required for the induction of antibacterial peptide genes in response to infection in Drosophila and acts by controlling activation of the NF-kappa B family transcription factor Relish.

1 Molecular Biology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
2 Molecular and Cell Biology Program, Weill Graduate School of Medical Sciences, Cornell University, 445 East 69th Street, New York, NY 10021, USA.
3 Umeå Centre for Molecular Pathogenesis, Umeå University, SE-901 87 Umeå, Sweden.
*   To whom correspondence should be addressed. E-mail: k-anderson{at}ski.mskcc.org

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