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PNAS 103 (20): 7889-7894

Copyright © 2006 by the National Academy of Sciences.

Sex-specific influences of vasopressin on human social communication

R. R. Thompson*,{dagger}, K. George*, J. C. Walton*, S. P. Orr{ddagger},§, and J. Benson*

*Psychology Department and Neuroscience Program, Bowdoin College, Brunswick, ME 04011; {ddagger}Department of Psychiatry at Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114; and §Veterans Affairs Medical Center, Manchester, NH 03104


Figure 1
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Fig. 1. Mean and SEM of stimulus-induced changes in corrugator EMG activity in men (A; saline, n = 18; AVP, n = 20) and women (B; saline, n = 18; AVP, n = 20) 15 min after drug administration. AVP significantly increased responses to neutral faces in men, whereas it significantly decreased responses to happy and angry faces in women (*, P < 0.05).

 

Figure 2
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Fig. 2. Mean and SEM of corrugator EMG responses in control men on the two stimulus sets. Responses to neutral faces were significantly larger on set 2 than set 1 (*, P < 0.05).

 

Figure 3
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Fig. 3. Mean and SEM of zygomaticus major EMG responses to faces in women on the second stimulus set, 50 min after drug administration (saline, n = 19; AVP, n = 17). AVP significantly increased zygomaticus responses to neutral faces (*, P < 0.05).

 

Figure 4
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Fig. 4. Mean and SEM of approachability ratings of faces on set 1 in men (A; saline, n = 18; AVP, n = 19) and women (B; saline, n = 16: AVP, n = 16). AVP significantly reduced ratings of happy faces in men and significantly increased ratings of neutral faces in women (*, P < 0.05).

 

Figure 5
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Fig. 5. Mean and SEM of SC responses to faces on set 1 (A; saline, n = 37; AVP, n = 37) and of minimum HR responses to faces on set 2 (B; saline, n = 30; AVP, n = 33) in men and women combined. AVP significantly increased SC responses to angry faces and significantly reduced HR decelerations to angry faces (*, P < 0.05).

 


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