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Science 331 (6024): 1529-1531

Copyright © 2011 by the American Association for the Advancement of Science

Selective Insulin Sensitizers

Ja Young Kim-Muller, and Domenico Accili

Department of Medicine and Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

Figure 1
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Integrated pathways in the liver. In response to food intake and an increase in blood glucose concentration, the hormones FGF19 and insulin control hepatic protein synthesis and glycogen production. Insulin also controls liver lipogenesis. In the diabetic liver, the effects of insulin are blocked. Treatment with FGF19 may selectively rescue glycogen and protein production without affecting lipid synthesis.



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