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Science 332 (6026): 186-187

Copyright © 2011 by the American Association for the Advancement of Science

Eosinophils Forestall Obesity

Rick M. Maizels, and Judith E. Allen

Centre for Immunity, Infection and Evolution and the Institute for Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, UK.

Figure 1
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Immune cells in fat. (Left) In healthy adipose tissue, eosinophils produce IL-4, which sustains alternatively activated macrophages (AAMs). Classical activation of macrophages (CAMs) is suppressed by regulatory T cells (Treg). Helminth infection may boost AAMs by expanding eosinophils, helper T cells, or both. (Right) In metabolic syndrome, high numbers of macrophages in adipose tissue are recruited and activated by T cells (CD8) or by inflammatory cytokines released from resident CAMs. Cytokines entering the circulation can cause insulin resistance. Adipose tissue releases resistin and free fatty acids into the circulation.



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