Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 334 (6062): 1501-1502

Copyright © 2011 by the American Association for the Advancement of Science

Autophagy in Tumor Immunity

Ravi K. Amaravadi

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.

Figure 1
View larger version (49K):
[in this window]
[in a new window]

Preventing or promoting tumor immunity. Chemotherapy-induced DNA damage activates apoptosis and autophagy. Autophagy is required for the release of ATP by cancer cells, which recruits dendritic cells and a T cell response. However, autophagy can also limit T cell-mediated cytotoxicity. MHC, major histocompatibility complex; TCR, T cell receptor.



To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882