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Science 334 (6062): 1501-1502

Copyright © 2011 by the American Association for the Advancement of Science

Autophagy in Tumor Immunity

Ravi K. Amaravadi

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.


Figure 1
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Preventing or promoting tumor immunity. Chemotherapy-induced DNA damage activates apoptosis and autophagy. Autophagy is required for the release of ATP by cancer cells, which recruits dendritic cells and a T cell response. However, autophagy can also limit T cell-mediated cytotoxicity. MHC, major histocompatibility complex; TCR, T cell receptor.

CREDIT: B. STRAUCH/SCIENCE

 


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