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Science 335 (6076): 1578-1579

Copyright © 2012 by the American Association for the Advancement of Science

Rapamycin Paradox Resolved

Katherine J. Hughes1, and Brian K. Kennedy1

1 Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.


Figure 1
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Uncoupled effects. Inhibition of mTORC1 by rapamycin promotes longevity, potentially by blocking protein translation (S6K1 inhibition); a role for other mTORC1 effectors is not yet known. Inhibition of mTORC2 by rapamycin causes insulin resistance and impairs glucose homeostasis potentially by blocking Akt, a major enzyme in glucose uptake and insulin responsiveness.

CREDIT: B. STRAUCH/SCIENCE

 


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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882