Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 335 (6076): 1578-1579

Copyright © 2012 by the American Association for the Advancement of Science

Rapamycin Paradox Resolved

Katherine J. Hughes1, and Brian K. Kennedy1

1 Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.

Figure 1
View larger version (41K):
[in this window]
[in a new window]

Uncoupled effects. Inhibition of mTORC1 by rapamycin promotes longevity, potentially by blocking protein translation (S6K1 inhibition); a role for other mTORC1 effectors is not yet known. Inhibition of mTORC2 by rapamycin causes insulin resistance and impairs glucose homeostasis potentially by blocking Akt, a major enzyme in glucose uptake and insulin responsiveness.



To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882