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Science 336 (6085): 1120-1121

Copyright © 2012 by the American Association for the Advancement of Science

When Less Signaling Is More

Oliver M. Bannard, and Jason G. Cyster

Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California–San Francisco, CA 94143–0414, USA.

Figure 1
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Constrained signaling. Signaling by the B cell receptor is restricted by phosphatases (such as SHP-1) in G1 phase of GC B cells, with possible effects on B cell fate. MHC II, major histocompatibility complex II.



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