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Science 337 (6097): 925-926

Copyright © 2012 by the American Association for the Advancement of Science

Glycosylation to Adapt to Stress

Katherine R. Mattaini1, and Matthew G. Vander Heiden1,2

1 Koch Institute for Integrative Cancer Research and the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
2 Dana-Farber Cancer Institute, Boston, MA 02115, USA.


Figure 1
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  		Converging on PFK1. PFK1 catalyzes the formation of FBP from F6P in glycolysis. Decreased PFK1 activity diverts glucose carbon from glycolysis and downstream biosynthetic pathways to the oxidative pentose phosphate pathway (PPP). This allows production of NADPH to maintain reduced glutathione pools (GSH) and allow cells to counteract oxidative stress. R5P, ribose-5-phosphate; GSH/GSSG, reduced/oxidized glutathione.

CREDIT: Y. HAMMOND/SCIENCE

 

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882