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Science 337 (6100): 1300-1301

Copyright © 2012 by the American Association for the Advancement of Science

Staging Membrane Fusion

Josep Rizo

Departments of Biophysics, Biochemistry, and Pharmacology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA.

Figure 1
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Generating force for membrane fusion. The states of the SNARE complex derived by Gao et al. are numbered. Helical regions are cylinders. The soluble parts of these SNAREs are colored (syntaxin-1, yellow; SNAP-25, green; synaptobrevin, orange). The transmembrane domains (dark gray) were not included in the study. The synaptic vesicle and plasma membranes are believed to approach and fuse as the SNARE complex assembles. The three synaptobrevin domains are amino-terminal domain, NTD; carboxyl-terminal domain, CTD; and linker domain, LD. LD may be normally unstructured but becomes helical in state 1.


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