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Science 337 (6102): 1616-1617

Copyright © 2012 by the American Association for the Advancement of Science

Immune Surveillance from Chromosomal Chaos?

Maurizio Zanetti, and Navin R. Mahadevan

Laboratory of Immunology, Department of Medicine, and Moores Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.


Figure 1
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  		Order from chaos. Hyperploidy in cancer cells activates the unfolded protein response in the endoplasmic reticulum (ER), which promotes the export of the ER-resident protein calreticulin to the cell surface where it elicits phagocytosis by macrophages and dendritic cells. These, in turn, present cancer cell antigens to T cells, driving their clonal expansion. The resulting killer T cells preferentially attack hyperploid cells, leading to attenuation or arrest of tumor growth.

CREDIT: Y. HAMMOND/SCIENCE

 

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