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Science 338 (6103): 51-52

Copyright © 2012 by the American Association for the Advancement of Science

Intestinal Wound Healing Requires a Wnt Balancing Act

Terrence A. Barrett

Department of Medicine and Microbiology/Immunology, Division of Gastroenterology, Northwestern University Medical School, Chicago, IL 60611, USA.

Figure 1
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Wnt5a is needed for wound healing. Image of transmural ulcer from a Crohn's disease resection specimen showing an area of hyperproliferative branching crypts producing an epithelial monolayer (EM). An area of epithelial channel clefting is highlighted (dark arrow).



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