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Science 338 (6104): 200-201

Copyright © 2012 by the American Association for the Advancement of Science

Putting the Squeeze on Phototransduction

Emily R. Liman

Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA.

Figure 1
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Fly phototransduction. Light stimulation of rhodopsin in a fly photoreceptor cell leads to the hydrolysis of PIP2 by phospholipase C (PLC), generating IP3, DAG, and a proton. Conversion of PIP2 to the slimmer molecule DAG on the inner leaflet of the membrane increases membrane tension, which opens dTRP channels and causes contraction of the microvillus. Intracellular acidification also activates the dTRP channels.



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