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Science 338 (6104): 206-207

Copyright © 2012 by the American Association for the Advancement of Science

Cilia Discern Left from Right

Dominic P. Norris, and Daniel T. Grimes

MRC Mammalian Genetics Unit, Oxfordshire OX11 0RD, UK.

Figure 1
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Feel the flow. (A) The early mouse embryo (day 8.25), showing asymmetric expression of the indicated genes around the node and laterally. (B) The node consists of a depression containing central pit cells with motile cilia and peripheral crown cells with immotile sensory cilia. (C) Cross section through the node showing Pkd1l1-Pkd2 complexes in crown cell cilia sensing leftward flow. The signaling pathway links fluid flow across the node with asymmetric gene expression.



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