Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Science 338 (6108): 748-749

Copyright © 2012 by the American Association for the Advancement of Science

A Decorated Virus Cannot Hide

Roland W. Herzog1, and David A. Ostrov2

1 Department of Pediatrics University of Florida, Gainesville, FL 32610, USA.
2 Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA.


Figure 1
View larger version (67K):
[in this window]
[in a new window]

 
Coated for binding. Upon entry into the blood, human adenovirus serotype 5 (HAdv5) is bound by blood clotting factor X (FX). After translocation to tissues, such as liver or spleen, resident macrophages sense the FX-bound virus through TLR4, which activates the innate immune mechanism against the virus (required for a potent antiviral response).

CREDIT: Y. HAMMOND/SCIENCE

 


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882