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Science 338 (6108): 748-749

Copyright © 2012 by the American Association for the Advancement of Science

A Decorated Virus Cannot Hide

Roland W. Herzog1, and David A. Ostrov2

1 Department of Pediatrics University of Florida, Gainesville, FL 32610, USA.
2 Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA.

Figure 1
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Coated for binding. Upon entry into the blood, human adenovirus serotype 5 (HAdv5) is bound by blood clotting factor X (FX). After translocation to tissues, such as liver or spleen, resident macrophages sense the FX-bound virus through TLR4, which activates the innate immune mechanism against the virus (required for a potent antiviral response).



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