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Science 338 (6109): 889-890

Copyright © 2012 by the American Association for the Advancement of Science

Promoting Tumorigenesis by Suppressing Autophagy

Itay Koren, and Adi Kimchi

Department of Molecular Genetics. Weizmann Institute of Science, Rehovot 76100, Israel.

Figure 1
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Phosphorylation and sequestration. (A) Phosphorylation of Beclin 1 with the indicated kinases either promotes or inhibits autophagy. (B) Beclin 1 is inactive when it associates with the dynein motor [dynein light chain 1/2 (DLC1/2)] and the microtubule cytoskeleton. Phosphorylation of Bim by JNK or of Ambra1 by ULK1, releases Beclin 1 and activates autophagy. Akt phosphorylates Beclin 1, allowing the adaptor protein 14-3-3 to link it to the cytoskeleton (vimentin and intermediate filaments). This blocks autophagy. P, phosphorylation; BH3, Bcl-2 homology 3 domain; CCD, coiled coil domain; ECD, evolutionarily conserved domain; JNK, c-Jun N-terminal kinase.



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