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Science 338 (6112): 1303-1304

Copyright © 2012 by the American Association for the Advancement of Science

Inflammation to Rebuild a Brain

Nephi Stella

Department of Pharmacology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA.


Figure 1
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Brain regeneration. In the zebrafish brain, injured neurons release a signal (LTC4) that stimulates resident immune cells (microglia, leukocytes, and other glia) to release a signal (LTC4) that promotes neurogenesis. The transcription factor Gata3 in both the immune cells and the neuronal progenitor cells may operate as a molecular switch that controls the repair phenotype of the inflammation.

CREDIT: K. SUTLIFF/SCIENCE

 


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