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Science 338 (6112): 1304-1305

Copyright © 2012 by the American Association for the Advancement of Science

Platelets Kill the Parasite Within

Christian R. Engwerda1, and Michael F. Good2

1 Queensland Institute of Medical Research, Brisbane, QLD Australia.
2 Institute for Glycomics, Griffith University, Gold Coast, QLD Australia.

Figure 1
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Destroying P. falciparum. (A) Activated platelets containing PF4-laden granules bind to parasitized red blood cells that express the Duffy-antigen receptor. (B) Upon binding [through CD36 on platelets and a parasite receptor on the red blood cell, possibly P. falciparum erythrocyte membrane protein 1 (PfEMP-1) (15)], PF4 is released and binds to the Duffy-antigen receptor on red blood cells. (C) The PF4–Duffy-antigen receptor complex translocates into the cell, colocalizes with intracellular parasites, and then kills the parasites.



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