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Science 339 (6116): 147-148

Copyright © 2013 by the American Association for the Advancement of Science

Improving Metabolism by Throwing Out All the JNK

Anthony W. Ferrante, Jr.

Department of Medicine, Naomi Berrie Diabetes Center, Columbia University, 1150 Saint Nicholas Avenue, New York, NY 10032, USA.

Figure 1
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Obesity and inflammation. In obesity, adipocyte hypertrophy and hyperplasia create the conditions shown, which trigger the activity of JNK1 and JNK2 in resident macrophages. This activation is required for subsequent immune cell recruitment to the adipose tissue, leading to a complex inflammatory response. Many of the secondary systemic metabolic sequalae also depend on JNK activation in adipose myeloid cells.



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