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Science 339 (6116): 148-150

Copyright © 2013 by the American Association for the Advancement of Science

When Metabolism and Epigenetics Converge

Paolo Sassone-Corsi

Center for Epigenetics and Metabolism, Department of Biological Chemistry, University of California, Irvine, CA 92697, USA.

Figure 1
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A plastic epigenome. DNA and histones are targets of multiple modifications that convey flexibility to the genome. These are elicited by modifiers whose activities are modulated by metabolites. The availability and subcellular compartmentalization of metabolites could contribute to the specificity of epigenetic control. Ac, acetylation; Me, methylation; P, phosphorylation; DNMTs, DNA methyltransferases; HMTs, histone methyltransferases; KDMs, lysine demethylases; FAD, flavin adenine dinucleotide.



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