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Science 339 (6117): 279-280

Copyright © 2013 by the American Association for the Advancement of Science

Hormones and the Social Brain

Bruce S. McEwen

Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10065 USA.

Figure 1
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Glucocorticoids and brain circuitry. (A) Social stress acts, in a glucocorticoid-dependent manner, on two dopamine-dependent pathways—the ventral tegmental area–to–nucleus accumbens and ventral tegmental area–to–frontal cortex—in the rodent brain to influence behavior (human brain shown). (B) Glucocorticoid actions on neurons are direct genomic, indirect genomic, and nongenomic, affecting the release of signaling factors, calcium buffering, and structural plasticity. mGR, membrane-associated glucocorticoid receptor.



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