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Science 339 (6118): 406-407

Copyright © 2013 by the American Association for the Advancement of Science

Chaperones That SNARE Neurotransmitter Release

Frederick M. Hughson

Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

Figure 1
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A model with Muncs. Syntaxin, freed by NSF from nonproductive complexes (as shown) binds in a closed conformation to Munc18. Munc13 chaperones the assembly of ternary v/t-SNARE complexes that contain syntaxin, SNAP-25, and synaptobrevin. Synaptotagmin-Ca2+ is required for efficient membrane fusion.



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