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Science 339 (6120): 652-653

Copyright © 2013 by the American Association for the Advancement of Science

Shielding Broken DNA for a Quick Fix

Jiri Lukas, and Claudia Lukas

Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3b, 2200 Copenhagen, Denmark.

Figure 1
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Protected ends. (A) At the site of a DNA double-strand break, Rif1 interacts with chromatin-bound and phosphorylated (P) 53BP1 to protect DNA ends against resection (executed in part by the BRCA1-CtIP complex). This allows DNA repair by the NHEJ mechanism. (B) In the absence of Rif1 (alone or with 53BP1), DNA ends undergo excessive resection, which may lead to unscheduled repair by HDR, and consequently to genomic instability. BARD1, BRCA1-associated RING domain protein 1.



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