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Science 339 (6122): 912-913

Copyright © 2013 by the American Association for the Advancement of Science

Bacterial Escape Artists Set Afire

Marija Cemma1,2, and John H. Brumell1,2,3

1 Cell Biology Program, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada. University of Toronto, Toronto, Ontario M5S1A8, Canada.
2 Department of Molecular Genetics,
3 Institute of Medical Science, University of Toronto, Toronto, Ontario, M5S1A8, Canada.

Figure 1
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Protection from pyroptosis. During infection, expression of caspase-11 is up-regulated through Toll-like receptor 4 and/or IFN-{gamma} receptor signaling. After bacterial escape from vacuoles, caspase-11 promotes pyroptosis, leading to bacterial clearance and host protection. It is unclear how caspase-11 detects cytosolic bacteria (dashed line), but a "noncanonical inflammasome" has been proposed. Caspase-1 activation by canonical inflammasomes also promotes pyroptosis under some conditions, in addition to mediating pro-inflammatory cytokine release.



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