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Science 339 (6123): 1044-1045

Copyright © 2013 by the American Association for the Advancement of Science

Welcome to the Microgenderome

Magdalena B. Flak, Joana F. Neves, and Richard S. Blumberg

Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School and Harvard Digestive Diseases Center, Boston, MA 02115, USA.

Figure 1
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Gender, microbes, and disease. Male puberty (in mice; not shown) leads to changes in the gut microbiota that reinforce testosterone production, which is protective against the development of T and B cell functions linked to autoimmune disease. In mice, the protective properties of the male-associated microbiota can be transferred to younger females and confer testosterone-mediated protection from autoimmune disease upon the recipients.



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