Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 339 (6126): 1388-1389

Copyright © 2013 by the American Association for the Advancement of Science

Making a Point with Wnt Signals

J. D. Berndt1, and R. T. Moon1,2

1 Department of Pharmacology, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98109, USA.
2 The Howard Hughes Medical Institute, Seattle, WA 98109, USA.

Figure 1
View larger version (50K):
[in this window]
[in a new window]

Orienting cell division. (A) A point source of Wnt3A leads to the asymmetric inheritance of β-catenin, proteins associated with self-renewal and pluripotency, and markers of differentiation. (B) Bath application of Wnt3A promotes symmetric distribution of these factors and results in two daughter cells with equally pluripotent cell fates.



To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882