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Science 339 (6126): 1388-1389

Copyright © 2013 by the American Association for the Advancement of Science

Making a Point with Wnt Signals

J. D. Berndt1, and R. T. Moon1,2

1 Department of Pharmacology, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98109, USA.
2 The Howard Hughes Medical Institute, Seattle, WA 98109, USA.


Figure 1
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Orienting cell division. (A) A point source of Wnt3A leads to the asymmetric inheritance of β-catenin, proteins associated with self-renewal and pluripotency, and markers of differentiation. (B) Bath application of Wnt3A promotes symmetric distribution of these factors and results in two daughter cells with equally pluripotent cell fates.

CREDIT: Y. HAMMOND/SCIENCE

 


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