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Science 340 (6129): 155-156

Copyright © 2013 by the American Association for the Advancement of Science

An Interferon Paradox

Pamela M. Odorizzi, and E. John Wherry

Institute for Immunology and Department of Microbiology, University of Pennsylvania Perelman School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA.

Figure 1
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Balancing dual roles. Type 1 interferons (IFN-α/β) may control viral replication and spread through two mechanisms. Antiviral responses include the expression of antiviral genes and the activation of specific immune cells. Immunomodulatory responses include the expression of immunosuppressive molecules, immune cell inhibition, and cell death. The balance of these responses may shift, with enhanced antiviral actions during acute infections and greater immunomodulatory effects during chronic infections.



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