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Sci. STKE, 25 April 2000
[DOI: 10.1126/scisignal.292000pe1]

Trans-endocytosis of Notch Movie

This movie shows how trans-endocytosis of Notch into Delta expressing cells contributes to Notch activation. N-ECD represents the Notch extracellular domain, N-ICD represents Notch intracellular domain, {delta} represents the Delta ligand. Animation created by BioCreations.

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Citation: H. Krämer, RIPping Notch Apart: A New Role for Endocytosis in Signal Transduction? Science's STKE (2000), http://stke.sciencemag.org/cgi/content/full/sigtrans;2000/29/pe1

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882