Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Science 330 (6004): 611-

Copyright © 2010 by the American Association for the Advancement of Science

Introduction

What Is Epigenetics?

Guy Riddihough, and Laura M. Zahn

Video: What Is Epigenetics?

This item requires the Flash plug-in (version 8 or higher). JavaScript must be enabled in your browser.

Download the latest version of the free Flash plug-in.

Science senior editor Guy Riddihough taps experts for their definition of epigenetics.

The cells in a multicellular organism have nominally identical DNA sequences (and therefore the same genetic instruction sets), yet maintain different terminal phenotypes. This nongenetic cellular memory, which records developmental and environmental cues (and alternative cell states in unicellular organisms), is the basis of epi-(above)–genetics.

The lack of identified genetic determinants that fully explain the heritability of complex traits, and the inability to pinpoint causative genetic effects in some complex diseases, suggest possible epigenetic explanations for this missing information. This growing interest, along with the desire to understand the "deprogramming" of differentiated cells into pluripotent/totipotent states, has led to "epigenetic" becoming shorthand for many regulatory systems involving DNA methylation, histone modification, nucleosome location, or noncoding RNA. This is to be encouraged, but the labeling of nongenetic systems as epigenetic by default has the potential to confuse (see the related video at www.sciencemag.org/special/epigenetics/).

So what is epigenetics? An epigenetic system should be heritable, self-perpetuating, and reversible (Bonasio et al., p. 612). Whether histone modifications (and many noncoding RNAs) are epigenetic is debated; it is likely that relatively few of these modifications or RNAs will be self-perpetuating and inherited. Looking beyond DNA-associated molecules, prions (infectious proteins) are clearly epigenetic, perpetuating themselves through altered folding states. These states can act as sensors of environmental stress and, through the phenotypic changes they promote, potentially drive evolution (Halfmann and Lindquist, p. 629).


Figure 1

CREDIT: C. BICKEL/SCIENCE

[Larger version of this image]

Some metazoans undergo genome-wide reprogramming of DNA methylation and histone modifications during gametogenesis and embryogenesis (Feng et al., p. 622), which may suppress the activity of potentially deleterious DNA sequences. Furthermore, the activity of various populations of small noncoding RNAs (Bourc' his and Voinnet, p. 617) probably act as tags for these deleterious sequences. These small RNAs may also be involved in assessing parental compatibility at fertilization. Similar RNAs are likely to be important determinants in paramutation, where homologous DNA sequences communicate in trans to establish heritable expression states (Chandler, p. 628). Reprogramming is also critical for developmental phenomena such as imprinting in both plants and mammals, as well as for cell differentiation, and is linked to the establishment of pluripotency in gametes and zygotes.

A News Focus story by Kaiser (p. 576) examines efforts to treat cancer patients with drugs that reverse the abnormal epigenetic patterns found in tumors, and a paper in Science Translational Medicine* describes the use of epigenetic markers to predict which liver cancer patients will respond to an anticancer drug that blocks DNA methylation. Papers in Science Signaling discuss signaling pathways that alter epigenetic patterning, posttranscriptional regulation of signaling molecules by microRNAs, and transcriptional networks. Articles on Science Careers trace careers embracing a translational approach to epigenetics.



* J. B. Andersen et al., Sci. Transl. Med. 2, 54ra77 (2010). Back



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882