A Correction to the Editors' Choice Summary Titled, "Common Senses" by Annalisa M. VanHook

The text as written implied that both fibroblast growth factor (FGF) ligands, NvFGFa1 and NvFGFa2, signaled through a mitogen-activated protein kinase (MAPK) cascade. The data are more consistent with NvFGFa1 acting as an agonist for the FGF receptor and stimulating a MAPK cascade, whereas NvFGFa2 appears to act as an antagonist and is unlikely to stimulate a MAPK cascade. Thus, two sentences in the Editors’ Choice text are incorrect.

The following are the corrected sentences:

"...Pharmacological experiments suggested that NvFGFa1 signaled through a mitogen-activated protein kinase (MAPK) cascade. ... Thus, two FGFs antagonize one another to induce the apical organ and at least NvFGFa1 signals through a pathway that is very much like the canonical FGF pathway of more complex animals."

The summary with the corrected sentence is available online (http://stke.sciencemag.org/cgi/content/abstract/1/18/ec168) starting 3 June 2008.

The original, incorrect sentences were:

"...Signaling through both NvFGFa1 and NvFGFa2 was mediated by a mitogen-activated protein kinase (MAPK) cascade as indicated by pharmacological experiments. ... Thus, two FGFs antagonize one another to induce the apical organ and do so through a pathway that is very much like the canonical FGF pathway of more complex animals."

The editors suggest the following Related Resources on Science sites:

In Science Signaling

EDITORS' CHOICE
Development
Common Senses

Annalisa M. VanHook (6 May 2008)
Sci. Signal. 1 (18), ec168. [DOI: 10.1126/stke.118ec168]
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