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Sci. Signal., 19 August 2008
[DOI: 10.1126/scisignal.133pe38]

Dinucleotide-Sensing Proteins: Linking Signaling Networks and Regulating Transcription (Interactive Structures)

Heather K. Lamb1, David K. Stammers2, and Alastair R. Hawkins1*

1 Institute for Cell and Molecular Biosciences, Catherine Cookson Building, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

2Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

*Corresponding author. E-mail, a.r.hawkins{at}ncl.ac.uk

Interactive Image 1. HSCARG asymmetric dimer is based on PDB entry 2EXX and visualized with JMOL (1). This is an interactive version of the molecular structure shown in Figure 1B. The HSCARG that is not bound to NADP+ is colored blue. The NADP+-bound HSCARG is red.
 
Interactive Image 2. Structure of the Gal80p super-repressor mutant, the activation domain of Gal4p, and NAD based on the PDB database entry 3BTS. This is an interactive version of the molecular structure shown in Figure 3. Gal80p is green, the Gal4p peptide is yellow, and NAD is shown as ball and stick.

Tips for using the JMOL applet (1). To move the image, click in the image and hold the mouse button down and move the mouse. To zoom in or out, click in the image and hold down the mouse button with the "Shift" key depressed. In Windows, right-clicking anywhere on the JMOL image, or using either mouse button to click on the "JMOL" in the lower right corner will generate a pop-up menu that provides many options for changing the view. To restore the original view, reload the page in the browser. Please note that you may need to move the JMOL interactive versions of the images to orient them the same as the static images.

Reference

  1. Jmol: an open-source Java viewer for chemical structures in 3D; www.jmol.org/.

Citation: H. K. Lamb, D. K. Stammers, A. R. Hawkins, Dinucleotide-Sensing Proteins: Linking Signaling Networks and Regulating Transcription. Sci. Signal. 1, pe38 (2008).


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