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Sci. Signal., 16 September 2008
[DOI: 10.1126/scisignal.1160755]

Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12

Christopher T. Veldkamp1, Christoph Seibert2, Francis C. Peterson1, Norberto B. De la Cruz1, John C. Haugner III1, Harihar Basnet1, Thomas P. Sakmar2, and Brian F. Volkman1*

1Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

2Laboratory of Molecular Biology and Biochemistry, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

This PDF file includes:

  • Supplementary Materials and Methods
  • Table S1. Statistics for 20 SDF12 conformers.
  • Table S2. Statistics for 20 conformers of the SDF12:p38 complex.
  • Table S3. Statistics for 20 conformers of the SDF12:p38-sY1 complex.
  • Table S4. Statistics for 20 conformers of the SDF12:p38-sY3 complex.
  • Supplementary References

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Technical Details

Format: Adobe Acrobat PDF

Size: 137 KB


*To whom correspondence should be addressed. E-mail: bvolkman{at}mcw.edu

Citation: C. T. Veldkamp, C. Seibert, F. C. Peterson, N. B. De la Cruz, J. C. Haugner III, H. Basnet, T. P. Sakmar, B. F. Volkman, Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12. Sci. Signal. 1, ra4 (2008).

© 2008 American Association for the Advancement of Science


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